Search results for "SHM"

Impaired Th1 responses in mice deficient in Epstein-Barr virus-induced gene 3 and challenged with physiological doses of Leishmania major.

2005

Protection against Leishmania major is dependent on IL-12 release from L. major-infected dendritic cells (DC) that induce IFN-gamma-producing Th1/Tc1 cells. IL-27, a novel member of the IL-12 family, is a heterodimer composed of p28 and IL-12p40-related Epstein-Barr virus-induced gene 3 (EBI3), and was shown to be produced by DC. In this study, we utilized EBI3-deficient mice to investigate the role of IL-27 in leishmaniasis using physiological low-dose infections that mimic natural transmissions. Lesions in EBI3(-/-) mice were significantly larger between weeks 3 and 10 post infection, reaching up to approximately threefold increased lesion volumes compared to wild types. In parallel, derm…

Space syntax analysis applied to urban street lighting: Relations between spatial properties and lighting levels

2019

According to the international technical standards, higher lighting levels (luminance and illuminance levels) are expected in trafficked and central roads (where restrictive minimum lighting requirements are necessary) and lower lighting levels are expected in peripheral and less trafficked roads. Starting from this assumption, in this paper, the authors analyse the correlations between spatial properties (expressed by spatial indicators, for example, the integration index and the choice index) and lighting levels (expressed by lighting parameters, for example luminance and illuminance) upon roads of an urban context. The analysis has been applied to the case study of the medium sized town …

Fever with perinasal and tongue lesions: A diagnostic challenge

2023

The diagnosis may be challenging, and high suspicion index should be maintained in immunosuppressed patients with unusual mucocutaneous lesions, even in non-endemic areas for mucocutaneous leishmaniasis.

Heterocyclic Diamines with Leishmanicidal Activity.

2021

Leishmaniasis is one of the world's most neglected diseases with a worldwide prevalence of 12 million people. There are no effective human vaccines for its prevention, and outdated drugs hamper treatment. Therefore, research aimed at developing new therapeutic tools to fight leishmaniasis remains a crucial goal today. With this purpose in mind, here, we present 10 new compounds made up by linking alkylated ethylenediamine units to pyridine or quinoline heterocycles with promising in vitro and in vivo efficacy against promastigote and amastigote forms of Leishmania infantum, Leishmania donovani, and Leishmania braziliensis species. Three compounds (2, 4, and 5) showed a selectivity index muc…

Current Advances in the Synthesis and Biological Evaluation of Pharmacologically Relevant 1,2,4,5-Tetrasubstituted-1H-Imidazole Derivatives

2019

:In recent years, the synthesis and evaluation of the biological properties of 1,2,4,5-tetrasubstituted-1H-imidazole derivatives have been the subject of a large number of studies by academia and industry. In these studies it has been shown that this large and highly differentiated class of heteroarene derivatives includes high valuable compounds having important biological and pharmacological properties such as antibacterial, antifungal, anthelmintic, anti-inflammatory, anticancer, antiviral, antihypertensive, cholesterol-lowering, antifibrotic, antiuricemic, antidiabetic, antileishmanial and antiulcer activities.:The present review with 411 references, in which we focused on the literatur…

IL-10 signaling in dendritic cells attenuates anti- Leishmania major immunity without affecting protective memory responses

2015

The significance of serum soluble IL-2 receptor as a marker for active visceral leishmaniasis in Sicilian patients

1992

SUMMARY Sera from nine Sicilian patients with confirmed visceral leishmaniasis (Leishmania donovani infantum; VL), at the moment of the diagnosis, during the course of the disease and after clinical recovery, were analysed for the concentration of soluble IL-2 receptor (sIL-2R). The results show that sIL-2R is a marker of disease activity, since it is in high concentration at the beginning of infection and returns to the normal range following successful chemotherapy. At the same time of serum analysis for sIL-2R, peripheral blood mononuclear cells (PBMC) of VL patients were stimulated with phytohaemagglutinin (PHA) or antigen and supernatant tested for IL-2 and interferon-gamma (IFN-γ) pro…

Carry a big stick, or no stick at all: Punishment and endowment heterogeneity in the trust game

2016

AbstractWe investigate the effect of costly punishment in a trust game with endowment heterogeneity. Our findings indicate that the difference between the investor and the allocator’s initial endowments determines the effect of punishment on trust and trustworthiness. Punishment fosters trust only when the investor is wealthier than the allocator. Otherwise, punishment fails to promote trusting behavior. As for trustworthiness, the effect is just the opposite. The higher the difference between the investor and the allocator’s initial endowments, the less willing allocators are to pay back. We discuss the consistency of our findings with social preference models (like inequality aversion, re…

Characterization of micromixing in a Continuous Oscillatory Baffled Reactor

2018

International audience; Micromixing is the limiting step in the progress of fast reactions and fast crystallization processes. Micromixing performance of a Nitech© glass COBR has been characterized using the competing parallel iodide-iodate test reactions. Macromixing length was also qualitatively determined by visualization of a tracer. The results show that an increase in the amplitude to baffle space ratio and a decrease of oscillation frequency improves mixing performance.

Abraham Bids Farewell to Hagar and Ishmael: Continuity and Variation of the Iconographic Type

2021

In traditional Christian artistic visualization, the episode of Hagar and Ishmael in the desert has given rise to various iconographic types: “The feast for the weaning of Isaac and Sara’s protests,” “Abraham bids farewell to Hagar and Ishmael,” “Hagar and Ishmael in the desert” and “Divine salvation for Hagar and Ishmael”. This study looks into the continuity and variation over time of the second of these types: “Abraham bids farewell to Hagar and Ishmael,” the one most depicted out of this entire biblical topic or episode. Since the Byzantine Octateuch in the East (11th century.) and the Canterbury Hexateuch (ca. 1025&ndash…