Search results for "SHM"

showing 10 items of 400 documents

In vivo and in vitro anti-leishmanial activities of 4-nitro-N-pyrimidin- and N-pyrazin-2-ylbenzenesulfonamides, and N2-(4-nitrophenyl)-N1-propylglyci…

2009

A series of compounds containing the nitrobenzene and sulfonamido moieties were synthesized and their leishmanicidal effect was assessed in vitro against Leishmania infantum promastigotes. Among the compounds evaluated, the p-nitrobenzenesulfonamides 4Aa and 4Ba, and the p-nitroaniline 5 showed significant activity with a good selectivity index. In a Balb/c mice model of L. Infantum, administration of compounds 4Aa, 4Ba or 5 (5 mg/kg/day for 10 days, injected ip route) led to a clear-cut parasite burden reduction (ca. 99%). In an attempt to elucidate their mechanism of action, the DNA interaction of 4Aa and 5 was investigated by means of viscosity studies, thermal denaturation and nuclease …

StereochemistryClinical BiochemistryNitro compoundGlycinePharmaceutical ScienceBiochemistryChemical synthesisMiceIn vivoDrug DiscoverymedicineAnimalsMolecular BiologyLeishmaniasischemistry.chemical_classificationNucleaseMice Inbred BALB CSulfonamidesAniline CompoundsbiologyOrganic Chemistrybiology.organism_classificationTrypanocidal AgentsIn vitroPyrimidineschemistryMechanism of actionBiochemistrybiology.proteinNitroMolecular MedicineLeishmania infantummedicine.symptomBioorganicmedicinal chemistry
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Understanding University Library Users' Mistreatment of Books

2009

This paper analyses university library users' attitudes towards book vandalism in order to develop a basis for intervention. Using a customer oriented approach data was collected from users who attended an academic library exhibition on vandalized books at a University campus. Respondants were asked both for their reactions to the vandalism as well as to suggest measures to solve this problem. Punishment and surveillance were most frequently mentioned as preventative measures although users also recognized the utility of the exhibition in increasing awareness of book mutilation. Further implications of social marketing for libraries are also discussed.

Stock managementPunishmentbusiness.industrymedia_common.quotation_subjectAcademic libraryLibrary and Information SciencesPublic relationsGeneralLiterature_MISCELLANEOUSSocial marketingEducationExhibitionOrder (business)Crime preventionIntervention (counseling)businessPsychologymedia_common
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Uptake of Leishmania major by dendritic cells is mediated by Fcγ receptors and facilitates acquisition of protective immunity

2006

Uptake of Leishmania major by dendritic cells (DCs) results in activation and interleukin (IL)-12 release. Infected DCs efficiently stimulate CD4- and CD8- T cells and vaccinate against leishmaniasis. In contrast, complement receptor 3-dependent phagocytosis of L. major by macrophages (MPhi) leads exclusively to MHC class II-restricted antigen presentation to primed, but not naive, T cells, and no IL-12 production. Herein, we demonstrate that uptake of L. major by DCs required parasite-reactive immunoglobulin (Ig)G and involved FcgammaRI and FcgammaRIII. In vivo, DC infiltration of L. major-infected skin lesions coincided with the appearance of antibodies in sera. Skin of infected B cell-de…

T cellImmunologyAntigen presentationLeishmaniasis CutaneousMacrophage-1 AntigenPriming (immunology)Complement receptorArticleImmunoglobulin GMicePhagocytosismedicineAnimalsImmunology and AllergyLeishmania majorCells CulturedLeishmania majorMice KnockoutB-LymphocytesMice Inbred BALB CbiologyMacrophagesReceptors IgGArticlesDendritic Cellsbiology.organism_classificationMice Inbred C57BLmedicine.anatomical_structureImmunoglobulin GImmunologybiology.proteinInterleukin 12CD8Journal of Experimental Medicine
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Skin Dendritic Cells in Murine Cutaneous Leishmaniasis

2002

Studies of the immunopathogenesis of Leishmania major-induced murine cutaneous leishmaniasis provide a framework for understanding the evolution of L. major infection of skin in humans and the foundation for rationale vaccine design. Experiments in which infection is initiated with "suprap hysiologic" numbers of parasites clearly identify Th-derived type I cytokines as essential participants in macrophage activation and macrophage nitric oxide production as prerequisite for parasite control. Dendritic cells, rather than macrophages, appear to be responsible for L. major-specific Th priming in these studies. Recent studies of murine cutaneous leishmaniasis in a model system in which infectio…

T cellImmunologyLeishmaniasis CutaneousPriming (immunology)CD8-Positive T-LymphocytesBiologyLymphocyte ActivationNitric oxideLesionMicechemistry.chemical_compoundCutaneous leishmaniasismedicineAnimalsHumansImmunology and AllergyParasite hostingLeishmania majorSkinLeishmaniasisHematologyDendritic cellmedicine.diseasemedicine.anatomical_structurechemistryLangerhans CellsImmunologyCytokinesChemokinesmedicine.symptomImmunobiology
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La stereotomia nella cattedra di Architettura statica di Carlo Giachery

2014

La scuola di architettura di Palermo, sin dalla sua fondazione nel 1779, con la creazione della cattedra di Architettura civile affidata a Giuseppe Venanzio Marvuglia, era divenuta inevitabilmente il luogo di verifica e talvolta di esplorazione dei temi legati alla pratica professionale e, quindi, all’arte del costruire. Giachery, Professore di Architettura statica e civile dal 1837 al 1865, è il primo ad avvertire, da docente, la crisi profonda del sistema didattico della scuola di architettura di Palermo isterilita dalla ricerca di astratte idealità neoclassiche e straniatasi dal processo evolutivo della cultura architettonica europea dopo la morte dei “maestri” Marviglia e Gentile. Secon…

The School of Architecture of Palermo since its founding in 1779 with the creation of the chair of Civil Architecture entrusted to Joseph Venantius Marvuglia has become the place of testing exploration of issues related to professional practice and the art of building. Carlo Giachery Professor of Static and Civil Architecture from 1837 to 1865 is the first to feel the deep crisis of the educational system of the school of architecture of Palermo. For him architecture and applied sciences to architecture found in their stereotomy confirmation of the existence of correspondent relationships in their evolutionary process. The notion of stereotomy taken by Carlo Giachery in teaching reconnects directly to the noble art of coupe des pierres. Taken together the teaching aids used to show a theoretical advance that Giachery inclined in the direction of elasticity of the materials. Noting the outcomes of teaching his students have the clear perception of how the teaching on stereotomy is the compendium of all the French tradition on the subject. With the establishment of the School of Application for Engineers and Architects in 1866 the steretomia seems to gradually lose interest in favor of the prevailing metal construction. All the wisdom of build which for centuries had been linked with art de la coupe des pierres gave way to new construction techniques and new materials.Settore ICAR/14 - Composizione Architettonica E Urbana
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Abitare nel reale. Dalla crisi della periferia alla tessitura di nuove relazioni contestuali

2019

I progetti redatti per “Palermo Sud-Est” sono il risultato di un Laboratorio di Laurea strutturatosi attraverso incontri, seminari, comunicazioni specialistiche, esposizioni critiche, che – in una strategia condivisa – ha visto ogni studente elaborare il proprio lavoro nel confronto con gli altri attori del Laboratorio stesso. La ricerca sui “progetti urbani” è stata impostata di modo che ogni laureando fosse messo a conoscenza dei progetti svolti nello stesso ambito territoriale dai colleghi che l’avevano preceduto, così da poter operare in continuità e contribuire a formulare un ragionamento unitario, nel quale ogni progetto costituisse continuazione, verifica o anche variante dei precede…

The projects prepared for "Palermo South-East" are the result of a Graduate Laboratory structured through meetings seminars specialist communications critical exhibitions which - in a shared strategy - saw each student elaborate their work in comparison with others actors of the same Laboratory. The research on "urban projects" was set so that each graduating student was made aware of the projects carried out in the same geographical area by the colleagues who had preceded it so as to be able to operate in continuity and contribute to formulating a unitary reasoning in which each project constituted continuation verification or even variant of the previous ones. These coordinated works have pursued two fundamental objectives: the strengthening of infrastructures and the establishment of specialized public buildings with superior functions aimed at requalifying and regenerating various critical situations with particular attention to the relationship between context and life scenarios. Thus each designer while dealing with a main functional program simultaneously deals with various issues such as the rationalization of the road system the redevelopment of existing buildings the design and refunctionalization of urban services (for example the transformed Central Station in the hotel or the project of a great Mosque)several degree theses have addressed as the main theme or as a question in the background the design of a new bed for the Oreto river and the relative establishment of a park facing it. In this desire to "patch up the wounds" in the different areas of "Palermo South-East" in close relationship with the vicissitudes of the place there is a continuous reference to architectures of all time and some questions involving the functional program are suggested - that identifies the character (or perhaps "type") of what is to be inserted in a given context - and the qualities of living reality as a pivotal material in the design process.Settore ICAR/14 - Composizione Architettonica E Urbana
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Mean Field Linear Quadratic Games with Set Up Costs

2013

This paper studies linear quadratic games with set up costs monotonic on the number of active players, namely, players whose action is non-null. Such games arise naturally in joint replenishment inventory systems. Building upon a preliminary analysis of the properties of the best response strategies and Nash equilibria for the given game, the main contribution is the study of the same game under large population. We also analyze the influence of an additional disturbance in the spirit of the literature on H∞ control. Numerical illustrations are provided. © 2012 Springer Science+Business Media New York.

TheoryofComputation_MISCELLANEOUSStatistics and ProbabilityComputer Science::Computer Science and Game TheoryEconomics and EconometricsMathematical optimizationSequential gamedifferential games game theory control and optimizationJoint-replenishmentOutcome (game theory)symbols.namesakeMean field gamesGame theoryMathematicsMean field games; Linear quadratic differential games; Joint-replenishment[INFO.INFO-NI] Computer Science [cs]/Networking and Internet Architecture [cs.NI]Applied MathematicsNormal-form gameComputingMilieux_PERSONALCOMPUTINGoperational researchTheoryofComputation_GENERALScreening gameComputer Graphics and Computer-Aided DesignComputer Science ApplicationsComputational MathematicsComputational Theory and MathematicsNash equilibriumBest responseRepeated gamesymbolsLinear quadratic differential gamesSettore MAT/09 - Ricerca OperativaoptimizationGame theoryMathematical economicsDynamic Games and Applications
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Contra el miedo

2007

Think tanks neoconservadoresCulturaHuntingtonVidal-Beneyto JoséChoque de civilizaciones11-SMIEDOKissingerIslamComentario colectivoPanorama intelectualPublicaciones: Obra periodística: Columnas y artículos de opiniónDefensaAmérica LatinaLegitimación geopolíticaEstablishmentInestabilidadCivilizacionesFantasma islámicoIDEOLOGÍABushSurEstados UnidosViejosJóvenesPosicionesOpinión pública mundialGuerra ideológicaInseguridadLibertadOccidenteLuchaEnfrentamientosReligión
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Mathematical formulation of pulse amplitude modulation selective harmonic elimination in multilevel three phase inverters

2022

In this paper multilevel cascaded H-bridges (CHB) three phase inverters with 2n dc sources, n=1,2,3,... are considered and a mathematical formulation providing both 2n switching angles and dc voltage source to eliminate n+1 harmonics and their respective multiple from their output voltage waveform, is proposed. The computed angles don't depend on modulation index and the source voltages linearly vary with it. The proposed procedure finds the solution through an analytical formula that avoids to solve transcendental systems and presents very low computational cost. A lot of low order harmonics are eliminated, returning a very low total harmonic distortion (THD). Particularly for 9-level conf…

Total Harmonic Distortion (THD)Selective Harmonics Elimination (SHE)Selective Harmonics Mitigation (SHM)Settore ING-IND/32 - Convertitori Macchine E Azionamenti ElettriciCascaded H-bridges (CHB) Multilevel Inverters
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Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice

2007

Abstract Protection against Leishmania major in resistant C57BL/6 mice is mediated by Th1 cells, whereas susceptibility in BALB/c mice is the result of Th2 development. IL-12 release by L. major-infected dendritic cells (DC) is critically involved in differentiation of Th1 cells. Previously, we reported that strain differences in the production of DC-derived factors, e.g., IL-1αβ, are in part responsible for disparate disease outcome. In the present study, we analyzed the release of IL-12 from DC in more detail. Stimulated DC from C57BL/6 and BALB/c mice released comparable amounts of IL-12p40 and p70. In the absence of IL-4, BALB/c DC produced significantly more IL-12p40 than C57BL/6 DC. D…

TransgeneImmunologyLeishmaniasis CutaneousMice TransgenicBiologyBALB/cMiceWestern blotSpecies SpecificityIn vivoImmunitymedicineImmunology and AllergyAnimalsLeishmania majorGenetic Predisposition to DiseaseCells CulturedLeishmania majorMice Inbred BALB Cmedicine.diagnostic_testInterleukin-12 Subunit p40Dendritic cellDendritic Cellsbiology.organism_classificationMolecular biologyInterleukin-12In vitroImmunity InnateMice Inbred C57BLImmunologyInterleukin-4DimerizationSignal Transduction
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