Search results for "SHM"

showing 10 items of 400 documents

Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis

2017

Healing of leishmaniasis-a parasitic skin disease-is associated with high levels of secreted interferon (IFN)γ and IL-12 in resistant C57BL/6 mice and humans. Susceptible BALB/c mice predominantly react with a Th17/Th2/Treg-related immune response and finally succumb to infection. Previously, we showed that BALB/c IL-17A-/- mice are protected against Leishmania (L.) major infections, indicating that IL-17A-predominantly produced by Th17 cells-plays an important role for disease outcome. We now investigated DC-derived cytokines and finally identified IL-23p19 as key cytokine responsible for induction of Leishmania-specific Th17 cells that play an important role for progressive disease in sus…

0301 basic medicinemedicine.medical_treatmentLeishmaniasis CutaneousDermatologyPolymerase Chain ReactionBiochemistryBALB/cInterferon-gammaMice03 medical and health sciences0302 clinical medicineImmune systemCutaneous leishmaniasisInterferonInterleukin 23AnimalsMedicineMolecular BiologyLeishmania majorMice Inbred BALB Cbiologybusiness.industryLeishmaniasisDendritic CellsLeishmaniabiology.organism_classificationmedicine.disease030104 developmental biologyCytokineImmunologyDisease ProgressionInterleukin-23 Subunit p19CytokinesTh17 Cellsbusiness030215 immunologymedicine.drugExperimental Dermatology

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La implosión de Occidente

2005

11-MSociedadVidal-Beneyto JoséRepresiónEnemigo comúnONUOCCIDENTETerrorismoHistoriaPublicaciones: Obra periodística: Columnas y artículos de opiniónMiseriaBloque occidentalUnión EuropeaEstablishmentNorteaméricaControlPaz socialGlobalizaciónImplosiónAntagonismoDesigualdadesUEUSAParoPaz políticaPrecariedad laboralPOLÍTICARacismoEE UUEstabilidad mundialIdeologíaEuropaURSS

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Disease control in cutaneous leishmaniasis is independent of IL-22.

2014

1303 BiochemistryLeishmaniasis Cutaneous610 Medicine & healthDermatology10263 Institute of Experimental ImmunologyBiochemistryInterleukin 222708 Dermatology1307 Cell BiologyCutaneous leishmaniasisparasitic diseasesmedicine1312 Molecular BiologyAnimalsMolecular BiologyMice Inbred BALB Cbusiness.industryInterleukinsCell Biologymedicine.diseaseDisease controlMice Inbred C57BLDisease Models AnimalImmunologyTh17 Cells570 Life sciences; biologybusiness

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An agent-based model of a cutaneous leishmaniasis reservoir host, Meriones shawi

2021

International audience; Meriones shawi (M.shawi) is the main reservoir host for zoonotic cutaneous leishmaniasis (ZCL) in Central Tunisia. The incorporation of environmental and climatic effects on the spread of ZCL in M. shawi remains difficult. This study presents an agent-based model (ABM) to overcome these difficulties and examine the impact of environment (i.e. vegetation cover) and climate (i.e. temperature) on M. shawi movement and prevalence. The model simulation considers two agent types: rodent agent and field unit agent. We tested the model according to two types of rodent movement: random and thoughtful. We integrated time dependent normalized difference vegetation index (NDVI) …

2. Zero hunger0106 biological sciencesAgent-based model[SDV.EE]Life Sciences [q-bio]/Ecology environmentMeriones shawibiologyEcology010604 marine biology & hydrobiologyEcological ModelingLand covermedicine.diseasebiology.organism_classification010603 evolutionary biology01 natural sciencesNormalized Difference Vegetation IndexVegetation coverCutaneous leishmaniasis13. Climate actionModel simulationmedicineZoonotic cutaneous leishmaniasis[SDE.BE]Environmental Sciences/Biodiversity and Ecology

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Solutions of the LPD equation and multi-parametric rogue waves

2022

Quasi-rational solutions to the Lakshmanan Porsezian Daniel equation are presented. We construct explicit expressions of these solutions for the first orders depending on real parameters. We study the patterns of these configurations in the (x, t) plane in function of the different parameters. We observe in the case of order 2, three rogue waves which move according to the two parameters. In the case of order 3, six rogue waves are observed with specific configurations moving according to the four parameters.

47.35.Fg47.10A-47.54.Bdquasi-rational solutions PACS numbers : 33Q5537K10[MATH.MATH-MP] Mathematics [math]/Mathematical Physics [math-ph]Lakshmanan Porsezian Daniel equation

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Hacia la ley europea del clima: las evaluaciones científicas y el futuro papel de las respuestas jurídicas de los estados miembros

2021

Los problemas climáticos son temas persistentes y omnipresentes dentro de las políticas y legislaciones contemporáneas, que exigen un enfoque interdisciplinario para promover soluciones jurídicas adecuadas para la complejidad del tema. Paradójicamente, las propagandas negacionistas, lejos de bloquear las acciones climáticas, las han propiciado, lo que ha llevado al establecimiento de un organismo científico super partes que reconociese las cuestiones climáticas a través de informes científicos avanzados: el Grupo Intergubernamental de Expertos sobre el Cambio Climático de la ONU (IPCC). Desde entonces, muchos países han usado los hallazgos del IPCC como base científica para desarrollar polí…

:CIENCIAS JURÍDICAS [UNESCO]Cambio Climático; Ley Europea del Clima; Pacto Verde Europeo IPCC; Derecho Público Comparadoas well as on the role that EU Members States? legislations will play in facing climate issues. Cambio climáticoIPCC2070-8157 22082 Revista Boliviana de Derecho 584568 2021 32 8055237 Hacia la ley europea del clima las evaluaciones científicas y el futuro papel de las respuestas jurídicas de los estados miembros ViolaEuropean Climate Lawinstead of blocking climate actionsleading to the establishment of a super partes scientific body that has acknowledged climate issues through the most advanced scientific reports: the UN Intergovernmental Panel on Climate Change (IPCC). Since thenPublic Comparative Law. 758 773demanding an interdisciplinary approach to foster legal solutions suitable for the complexity of the subject. Paradoxicallyhave fostered themEU Green DealPasquale Climate issues are persistent and pervasive topics within contemporary policies and legislationsmany countries have adopted the findings of the IPCC as scientific basis for developing strategic policies and legislation with the aim of combining adaptation and mitigation efforts. To this extentmainly focusing on the IPCC scientific basis and the proposed EU regulation related to climate changePacto Verde Europeo IPCCUNESCO::CIENCIAS JURÍDICASPacto Verde EuropeoCambio ClimáticoDerecho Público Comparadothe EU Green Deal and the future European Climate Law exemplify such contemporary attitude. This essay analyses the aforementioned assumptionsClimate changeLey Europea del Climanegationist claimsthe UN Intergovernmental Panel on Climate Change (IPCC). Since then [leading to the establishment of a super partes scientific body that has acknowledged climate issues through the most advanced scientific reports]

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Latvijas Vēstures Institūta Žurnāls. 2017, Nr. 3 (104)

2017

Valsts kultūrkapitāla fonds

:HUMANITIES and RELIGION::History and philosophy subjects::Archaeology subjects [Research Subject Categories]World War I and Latvian Riflemen in the Collective Memory:HUMANITIES and RELIGION::History and philosophy subjects::History subjects [Research Subject Categories]RecenzijasThe Religious and Socio-Political Context for the Establishment of the Firts Baptist ParishesWomen in the Families of Riga Trade Assistant Professions in the Course of Three Generations in the 18th CenturyĪsziņasProtection of Architectural HeritageThe Invented Traditions

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Premis, càstigs i educació

2008

Els autors defensen que el costum i la llei confi guren la legalitat i la moralitat socials i determinen el nostre comportament, alhora que qüestionen els resultats 'esperats' de l'aplicació mecànica dels premis i càstigs en educació. Distingeixen el control extern 'supervisió' i l'intern 'motivació' en l'esdevenir dels comportaments analitzats, en relació a l'aplicació d'aquelles sancions i tot seguit aborden l'estudi monogràfi c des del conductisme, des del cognitivisme i des de la perspectiva moral. Ara aborden la complexitat contextual de la intervenció pedagògica i les alternatives possibles des dels plantejaments actitudinals dels subjectes, per concloure que els premis tenen la fi na…

:PSICOLOGÍA [UNESCO]Costum i llei legalitat i moralitat comportaments premis i càstigs control extern i control intern conductisme cognitivisme perspectiva moral intervenció pedagògica dimensió afectiva bases psicològiques de l'educació sentit optimitzador. Habit and law legality and morality behaviors rewards and punishments external and internal control behaviorism cognitive moral perspective pedagogic intervention affective dimension psychological bases of the education optimizer sense. ArtículoUNESCO::PSICOLOGÍA

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[1,2,3]Triazolo[1,5-a]piridinas y compuestos relacionados : aplicaciones en química supramolecular : actividad biológica

2013

Los heterociclos nitrogenados son moléculas clave dentro de numerosos campos científicos. En concreto, los triazoles han encontrado numerosas aplicaciones en química médica como antifúngicos (fluconazol, posaconazol), antidepresivos (trazodona) o anticancerígenos (triazoloacridonas). En este contexto se decidió sintetizar nuevos derivados de [1,2,3]triazolo[1,5-a]piridinas con el fin de explorar su capacidad de interaccionar con ADN y su actividad leishmanicida y antichagásica. Con este objetivo se ha utilizado la química clásica de las triazolopiridinas (reacción de litiación regioselectiva de este heterociclo, seguida de adición de un electrófilo), para obtener nuevos derivados con estruc…

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The role of punishment in the works of Adam Smith

2009

The reformation of criminal justice is one of the great themes in Enlightenment culture and concerned its main exponents from Montesquieu to Beccaria, Filangieri, Bentham. One of the traits of greater modernity in the theories worked out by juridical Enlightenment is the resort to the utilitarianinspired economic analysis. Adam Smith doesn't back out of this scientific and civil commitment, but his doctrine appears significantly different though contemporary to juridical Enlightenment, and is also based on economic argumentations. In this work we will look through the main writings which contain the Smithian thought in search of those parts dealing with the theme of punishment and its socia…

Adam Smith Theory Of Moral Sentiments Glasgow Lectures An Enquiry Into The Nature And Causes Of The Wealth Of Nations Scottish Enlightenment Punishment Natural law Utilitarianism economic analysis of law. JEL classification codes: B11 B31 K14Settore SECS-P/04 - Storia Del Pensiero Economico

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