Search results for "SID"
showing 10 items of 6756 documents
Duodenal contractile activity in dystrophic (mdx) mice: reduction of nitric oxide influence.
2003
The present study was undertaken to analyse duodenal contractility in adult dystrophic (mdx) mice. The spontaneous changes of the isometric tension and the responses of longitudinal duodenal muscle to nonadrenergic, noncholinergic (NANC) nerve stimulation and to exogenous drugs were compared between normal and mdx mice. Duodenal segments from mdx mice displayed spontaneous contractions with higher frequency than normals. N omega-nitro-L-arginine methyl ester (L-NAME) increased the frequency of contractions in normals without affecting that in mdx mice. In normals, NANC nerve stimulation elicited a transient relaxation abolished by L-NAME. In mdx mice a frank relaxation was not observed, the…
Residual Stress Effects on Fatigue Crack Growth in Ti-6Al-4V Friction Stir Welds
2008
Recent studies have illustrated a predominant role of the residual stress on the fatigue crack growth in friction stir welded joints. In this study, the role of the residual stress on the propagation of fatigue cracks orthogonal to the weld direction in a friction stir welded Ti-6Al-4V joint was investigated. A numerical prediction of the fatigue crack growth rate in the presence of the residual stresses was carried out using AFGROW software; reasonable correspondence between the predictions and the experimental results were observed when the effects of residual stress were included in the simulation.
In Silico Analysis of Bone Tension During Fixation of the Medial Malleolus Fracture After Ankle Joint Endoprosthesis
2020
Total ankle arthroplasty (TAR) is a procedure alternative to arthrodesis which enables the biomechanical stabilization of the ankle joint. The procedure is associated with a high risk of complications, including fractures of the medial malleolus. In this study, the finite element method (FEM), based on CT examinations, was used to model the ankle fracture fixation after TAR. Three types of fracture stabilization were considered: screw, Blount staple, and both screw and Blount staple. In the in silico model, the maximum stress tension was found at prosthetic junctions with the base, cone, and talar components of the tibial prosthesis. When the fracture was stabilized with the Blount staple, …
Functional characterization of osteosarcoma cell lines provides representative models to study the human disease
2011
Cancer cell lines represent in vitro models for studying malignancies, general cell biology, drug discovery and more. Whether they can be considered as exact representative models of the parental tumors remains uncertain given the acquisition of additional ex vivo changes of the cells and the lack of tissue architecture and stroma. Previously, within the EuroBoNeT consortium, we characterized a collection of bone sarcoma cell lines on genomic and proteomic level. Here, we address the phenotypical and functional characterization of the unique set of osteosarcoma cell lines (n=19) in vitro and in vivo. For functional analysis of differentiation capacity, cells were stimulated towards osteobla…
Granuloma anulare disseminatum als seltene Nebenwirkung von Allopurinol
1995
During long-term therapy of hyperuricaemia with allopurinol (300 mg/d) two patients developed generalized granuloma annulare. The diagnoses were confirmed by histology; concomitant diseases, especially diabetes mellitus, were not detectable. Following discontinuation of allopurinol therapy, cutaneous granulomas healed without relapse. Hyperuricaemia could be controlled by low-purine diet and medication avoiding allopurinol. The clinical history of our two patients suggested a causal connection between allopurinol therapy and generalized granuloma annulare. For this reason we rate the development of this disease in both cases as a rare but significant side effect of allopurinol. This should …
Warm-Up and Hamstrings Stiffness, Stress Relaxation, Flexibility, and Knee Proprioception in Young Soccer Players
2022
Context: Nerves or fascia may limit motion in young soccer players, thereby contributing to frequent hamstring injuries. Nerve gliding exercises and self-myofascial release techniques may enhance the range of motion. Objective: The aim of this study was to compare the acute effect of foam rolling (FR) and neurodynamic nerve gliding (NDNG) on hamstring flexibility, passive stiffness, viscoelasticity and proprioception during the warm-up of soccer players. Design: Crossover study design. Setting: Research laboratory. Participants: Fifteen male soccer players on the same team (age 18.0 ± 1.4 years, body mass 76.9 ± 7.8 kg, height 183 ± 6 cm). Intervention: FR and NDNG included six sets of 45 s…
El periplo del objeto mitológico: itinerarios simbólicos del arte prehispánico entre los siglos XVI y XX
2014
Resumen : El presente texto discute la “identidad” que los objetos de arte prehispanico adquirieron desde el siglo XVI hasta mediados del siglo XX de acuerdo a los circuitos que recorrieron y los sujetos que los coleccionaron, miraron y pensaron. Itinerarios concretos: del contexto ritual al gabinete de curiosidades, del gabinete al museo arqueologico, del museo arqueologico a la muestra en espacios de arte. Itinerario que expresa las significaciones que el moderno Occidente les asigno en relacion a sus propias necesidades, anhelos y carencias. --------------------------- Abstract : This text discusses the "identity" that pre-Hispanic art objects acquired from the sixteenth to the twentieth…
"Tunne oli kuin Mozartilla välillä" : prosessidraama musiikinhistorian opetuksessa
2015
Tutkielma käsittelee prosessidraaman käyttöä peruskoulun 7. luokan musiikinhistorian opetuksessa musiikkitunneilla. Aineistoni on kerätty 2007-2008 opettamissani luokissa lounaissuomalaisessa koulussa. Toimintatutkimuksen ote on etnografinen ja narratiivinen. Tutkimuksella olen hakenut välineitä musiikinhistorian opetuksen kehittämiseen. Tutkimustavoitteenani oli selvittää miten prosessidraama soveltuu musiikinhistorian opetukseen, millaisia esteettisiä kokemuksia prosessidraaman avulla voi syntyä ja miten oppilaat innostuvat musiikinhistorian opetuksesta draaman avulla. Teoreettinen viitekehys koostuu musiikki- ja draamakasvatusfilosofioiden välisestä keskustelusta, jossa kokemuksellisuus,…
Molecular and Macromolecular Changes in Bottle-Aged White Wines Reflect Oxidative Evolution–Impact of Must Clarification and Bottle Closure
2018
This article is part of the Research Topic "The Chemistry of Wine Ageing" Adresse de correspondance: Institut Universitaire de la Vigne et du Vin, Dijon, France PMCID: PMC5897750; International audience; Chardonnay wines from Burgundy, obtained from musts with three levels of clarification (Low, Medium and High) during two consecutive vintages (2009 and 2010) and for two kinds of closures (screw caps and synthetic coextruded closures) were analyzed chemically and sensorially. Three bottles per turbidity level were opened in 2015 in order to assess the intensity of the reductive and/or oxidative aromas (REDOX sensory scores) by a trained sensory panel. The chemical analyses consisted in poly…
NEO1 and NEO-EXT studies: Long-term safety of repeat avalglucosidase alfa dosing for 4.5 years in late-onset Pompe disease patients
2019
Safety, tolerability, pharmacokinetics, pharmacodynamics, and exploratory efficacy of repeat avalglucosidase alfa dosing (5, 10, or 20 mg/kg qow) for 6 months were evaluated in NEO1 (NCT01898364) in late-onset Pompe disease patients either treatment-naive (Naive) or having received alglucosidase alfa for ≥9 months (Switch). In NEO-EXT (NCT02032524), an ongoing NEO1 extension, long-term safety and pharmacokinetics of repeat avalglucosidase alfa dosing will be monitored over 6 years. Interim safety results after 4.5 years of NEO-EXT are reported here. Mean ages at NEO1 enrollment were: Naive: 44.8 (SD:20.3, range:20-78) years and Switch: 46.7 (SD:14.1, range:21-68) years. Of the 24 NEO1 parti…