Search results for "SIMULATION"

The effect of wind on jumping distance in ski jumping – fairness assessed

2012

The special wind compensation system recently adopted by Federation Internationale de Ski (FIS; International Ski Federation) to consider the effects of changing wind conditions has caused some controversy. Here, the effect of wind on jumping distance in ski jumping was studied by means of computer simulation and compared with the wind compensation factors used by FIS during the World Cup season 2009/2010. The results showed clearly that the effect of increasing head/tail wind on jumping distance is not linear: +17.4 m/ − 29.1 m, respectively, for a wind speed of 3 m/s. The linear formula used in the trial period of the wind compensation system was found to be appropriate only for a limited…

Geothermal Gases Shape the Microbial Community of the Volcanic Soil of Pantelleria, Italy

2020

The Favara Grande nature reserve on the volcanic island of Pantelleria (Italy) is known for its geothermal gas emissions and high soil temperatures. These volcanic soil ecosystems represent “hot spots” of greenhouse gas emissions. The unique community might be shaped by the hostile conditions in the ecosystem, and it is involved in the cycling of elements such as carbon, hydrogen, sulfur, and nitrogen. Our metagenome study revealed that most of the microorganisms in this extreme environment are only distantly related to cultivated bacteria. The results obtained profoundly increased the understanding of these natural hot spots of greenhouse gas production/degradation and will help to enrich …

Substrate promiscuity in DNA methyltransferase M.PvuII. A mechanistic insight

2012

M.PvuII is a DNA methyltransferase from the bacterium Proteus vulgaris that catalyzes methylation of cytosine at the N4 position. This enzyme also displays promiscuous activity catalyzing methylation of adenine at the N6 position. In this work we use QM/MM methods to investigate the reaction mechanism of this promiscuous activity. We found that N6 methylation in M.PvuII takes place by means of a stepwise mechanism in which deprotonation of the exocyclic amino group is followed by the methyl transfer. Deprotonation involves two residues of the active site, Ser53 and Asp96, while methylation takes place directly from the AdoMet cofactor to the target nitrogen atom. The same reaction mechanism…

Nonlinear contractions involving simulation functions in a metric space with a partial order

2015

Very recently, Khojasteh, Shukla and Radenovic [F. Khojasteh, S. Shukla, S. Radenovic, Filomat, 29 (2015), 1189-1194] introduced the notion of Z-contraction, that is, a nonlinear contraction involving a new class of mappings namely simulation functions. This kind of contractions generalizes the Banach contraction and unifies several known types of nonlinear contractions. In this paper, we consider a pair of nonlinear operators satisfying a nonlinear contraction involving a simulation function in a metric space endowed with a partial order. For this pair of operators, we establish coincidence and common fixed point results. As applications, several related results in fixed point theory in a …

Sustainable strategies for small companies competing 
against multinational giants

2012

Computational modeling and experimental characterization of fluid dynamics in micro-CT scanned scaffolds within a multiple-sample airlift perfusion b…

2023

The perfusion of flow during cell culture induces cell proliferation and enhances cellular activity. Perfusion bioreactors offer a controlled dynamic environment for reliable in vitro applications in the tissue engineering field. In this work, to evaluate the effects of the operating parameters of a custom-made bioreactor, numerical simulations were performed to solve the fluid velocity profile inside the bioreactor containing multi-grid support that allows allocating of multiple seeded scaffolds at the same time. The perfusion system exhibited a uniform distribution of liquid velocities within the regions, suitable for cell growth on seeded scaffolds. The effects of the porous microstructu…

An ACE Wholesale Electricity Market Framework with Bilateral Trading

2011

In this paper, an agent-based simulation model for a hybrid power market structure is presented. A bilateral transaction mechanism is combined with a uniform-pricing auction settlement in order to isolate the impact of medium-term bilateral contracts on market power and spot prices in a competitive wholesale market setting. First we describe the negotiation method for bilateral trading of energy and then introduce a new approach for bidding in the DA market based on the load duration curve. We find that, despite the conventional concerns, the foreclosure effect produced by the bilateral agreement between a generation and a retail business will not necessarily lead to higher prices, and will…

Simplified model to evaluate the fate of micropollutants in an integrated urban drainage system: sensitivity analysis

2016

The paper presents the sensitivity analysis of an integrated urban water quality system by means of the global sensitivity analysis (GSA). Specifically, an home-made integrated model developed in previous studies has been modified in order to include the micropollutant assessment (namely, sulfamethoxazole - SMX). The model takes into account also the interactions between the three components of the system: sewer system (SS), wastewater treatment plant (WWTP) and the receiving water body (RWB). The analysis has been applied to an experimental catchment nearby Palermo (Italy): the Nocella catchment. Five scenarios each characterized by different combinations of sub-systems (i.e., SS, WWTP and…

A Setup for Microscopic Studies of Ultrasounds Effects on Microliters Scale Samples: Analytical, Numerical and Experimental Characterization

2021

International audience; Sonoporation is the process of cell membrane permeabilization, due to exposure to ultrasounds. There is a lack of consensus concerning the mechanisms of sonoporation: Understanding the mechanisms of sonoporation refines the choice of the ultrasonic parameters to be applied on the cells. Cells’ classical exposure systems to ultrasounds have several drawbacks, like the immersion of the cells in large volumes of liquid, the nonhomogeneous acoustic pressure in the large sample, and thus, the necessity for magnetic stirring to somehow homogenize the exposure of the cells. This article reports the development and characterization of a novel system allowing the exposure to …

Editorial: Calculation of Passenger Car Equivalents at Roundabouts

2021

Editorial on the Research Topic: Calculation of Passenger Car Equivalents at Roundabouts About this Research Topic: Calculation of Passenger Car Equivalents (PCEs) for heavy vehicles represents the starting point for the operational analysis of road facilities and other traffic management applications. PCEs are used to consider the presence of heavy vehicles in the traffic stream and are expressed as multiples of the effect of an average passenger car. Moreover, the highly curvilinear nature of the roundabout design, both in urban and rural environment, has significant effects on the paths that heavy vehicles would travel; as a consequence, the interaction between the physical and performan…