Search results for "SIMULATION"

Spectral broadening of the Soret band in myoglobin: an interpretation by the full spectrum of low-frequency modes from a normal modes analysis.

2005

In this work the temperature dependence of the Soret band line shape in carbon-monoxy myoglobin is re-analyzed by using both the full correlator approach in the time domain and the frequency domain approach. The new analyses exploit the full density of vibrational states of carbon-monoxy myoglobin available from normal modes analysis, and avoid the artificial division of the entire set of vibrational modes coupled to the Soret transition into "high-frequency" and "low-frequency" subsets; the frequency domain analysis, however, makes use of the so-called short-times approximation, while the time domain one avoids it. Time domain and frequency domain analyses give very similar results, thus s…

Dendritic Ih selectively blocks temporal summation of unsynchronized distal inputs in CA1 pyramidal neurons.

2004

The active dendritic conductances shape the input-output properties of many principal neurons in different brain regions, and the various ways in which they regulate neuronal excitability need to be investigated to better understand their functional consequences. Using a realistic model of a hippocampal CA1 pyramidal neuron, we show a major role for the hyperpolarization-activated current, I-h, in regulating the spike probability of a neuron when independent synaptic inputs are activated with different degrees of synchronization and at different distances from the soma. The results allowed us to make the experimentally testable prediction that the I-h in these neurons is needed to reduce ne…

Systematic uncertainties from halo asphericity in dark matter searches

2015

Although commonly assumed to be spherical, dark matter halos are predicted to be non-spherical by N-body simulations and their asphericity has a potential impact on the systematic uncertainties in dark matter searches. The evaluation of these uncertainties is the main aim of this work, where we study the impact of aspherical dark matter density distributions in Milky-Way-like halos on direct and indirect searches. Using data from the large N-body cosmological simulation Bolshoi, we perform a statistical analysis and quantify the systematic uncertainties on the determination of local dark matter density and the so-called $J$ factors for dark matter annihilations and decays from the galactic …

Improvement of neutron sensitivity for lithium formate ESR dosimeters: A Monte Carlo analysis

2023

This work presents the computational analysis of the sensitivity improvements that could be achieved in lithium formate monohydrate (LFM) electron paramagnetic resonance (EPR) dosemeters exposed to neutron beams. Monte Carlo (MC) simulations were performed on LFM pellets exposed to neutron beams with different energy spectra at various depths inside a water phantom. Various computations were carried out by considering different enrichments of 6Li inside the LFM matrix as well as addition of different amounts of gadolinium oxide inside the pellet blend. The energy released per unit mass was calculated with the aim of redicting the increase in dose achievable by the addition of sensitizers in…

Update of the search for supersymmetric particles in scenarios with Gravitino LSP and Sleptons NLSP

2001

An update of the search for sleptons, neutralinos and charginos in the context of scenarios where the lightest supersymmetric particle is the gravitino and the next-to-lightest supersymmetric particle is a slepton, is presented, together with the update of the search for heavy stable charged particles in light gravitino scenarios and Minimal Supersymmetric Standard Models. Data collected in 1999 with the DELPHI detector at centre-of-mass energies around 192, 196, 200 and 202 GeV were analysed. No evidence for the production of these supersymmetric particles was found. Hence, new mass limits were derived at 95% confidence level.

Search for supersymmetric particles in scenarios with a gravitino LSP and stau NLSP

2000

Sleptons, neutralinos and charginos were searched for in the context of scenarios where the lightest supersymmetric particle is the gravitino. It was assumed that the stau is the next-to-lightest supersymmetric particle. Data collected with the DELPHI detector at a centre-of-mass energy near 189 GeV were analysed combining the methods developed in previous searches at lower energies. No evidence for the production of these supersymmetric particles was found. Hence, limits were derived at 95% confidence level.

Exploring the dynamics of AChBP unbound and bound to the Lobeline partial agonist

2012

Study of the Density and Temperature Dependences of the Vibrational Raman Transition in Compressed Liquid N2

1991

0021-9606; Accurate values of linewidth and line shift in the isotropic vibrational Raman spectrum of compressed liquid N2 have been obtained by using inverse Raman spectroscopy. Experiments have been performed for eight isotherms, from the normal boiling point to the critical point temperatures of N2, the number density varying between the value on the coexistence line, and the maximum value of 2.1 x 10^22 cm-3. Minima of the linewidth have been observed above 86 K, showing the increasing influence of vibration-rotation coupling (motional narrowing) competing with the broadening due to pure vibrational dephasing. Moreover, for the first time, maxima of the red line shifts have been found, …

Electrical Conduction in Carbon Nanotubes under Mechanical Deformations

2009

The enormous potential of carbon nanotubes (CNTs) as primary components in electronic devices and NEMS necessitates the understanding and predicting of the effects of mechanical deformation on electron transport in CNTs. In principle, detailed atomic/electronic calculations can provide both the deformed configuration and the resulting electrical transport behavior of the CNT. However, the computational expense of these simulations limits the size of the CNTs that can be studied with this technique and a direct analysis of CNTs of the dimension used in nano-electronic devices, particularly multi-wall CNTs (MWNTs), seems prohibitive at the present. Here a computationally effective mixed finit…

Biomolecular conjugation inside synthetic polymer nanopores via glycoprotein-lectin interactions

2011

We demonstrate the supramolecular bioconjugation of concanavalin A (Con A) protein with glycoenzyme horseradish peroxidase (HRP) inside single nanopores, fabricated in heavy ion tracked polymer membranes. Firstly, the HRP-enzyme was covalently immobilized on the inner wall of the pores using carbodiimide coupling chemistry. The immobilized HRP-enzyme molecules bear sugar (mannose) groups available for the binding of Con A protein. Secondly, the bioconjugation of Con A on the pore wall was achieved through its biospecific interactions with the mannose residues of the HRP enzyme. The immobilization of biomolecules inside the nanopore leads to the reduction of the available area for ionic tran…