Search results for "SIMULATION"

On the function of modified nucleosides in the RNA world.

1998

Presumably ribosome and transfer RNA (tRNA) evolved from a pre-existing function in the RNA stage of life and were secondarily adapted for protein synthesis. Various possible initial functions of the primitive ribosome (protoribosome) have been suggested. The initial function of the primitive ribosome and primitive genetic translation would have been quite similar. It is possible that, initially, both functions coexisted in the protoribosome. Given that the three-dimensional structure of ribosomal RNAs shows only minor variations throughout time, it is, then, most likely that present ribosomes can still recall (remember) the most important parts of the mechanism of their initial function. A…

Macroscopic Dynamic Effects of Migrations in Patchy Predator-prey Systems

1997

Abstract Different mechanisms at the behaviourial or physiological levels determine many properties of predator-prey systems at the population level. In this paper, we present a method of obtaining complex predator-prey dynamic models from models at a detailed, behaviourial level of description. We consider a multi-patch predator-prey model, the dynamics of which contains two time-scales: a fast one, associated with migrations between patches, and a slow one, on which interactions, reproduction and mortality occur. We use methods of perturbation theory in order to aggregate the multi-patch system into a reduced system of two differential equations for the total prey and predator populations…

Mixture Analysis in Biology: Scope and Limits

1998

Modular Structures on Trace Class Operators and Applications to Landau Levels

2009

The energy levels, generally known as the Landau levels, which characterize the motion of an electron in a constant magnetic field, are those of the one-dimensional harmonic oscillator, with each level being infinitely degenerate. We show in this paper how the associated von Neumann algebra of observables displays a modular structure in the sense of the Tomita–Takesaki theory, with the algebra and its commutant referring to the two orientations of the magnetic field. A Kubo–Martin–Schwinger state can be built which, in fact, is the Gibbs state for an ensemble of harmonic oscillators. Mathematically, the modular structure is shown to arise as the natural modular structure associated with the…

From deterministic cellular automata to coupled map lattices

2016

A general mathematical method is presented for the systematic construction of coupled map lattices (CMLs) out of deterministic cellular automata (CAs). The entire CA rule space is addressed by means of a universal map for CAs that we have recently derived and that is not dependent on any freely adjustable parameters. The CMLs thus constructed are termed real-valued deterministic cellular automata (RDCA) and encompass all deterministic CAs in rule space in the asymptotic limit $\kappa \to 0$ of a continuous parameter $\kappa$. Thus, RDCAs generalize CAs in such a way that they constitute CMLs when $\kappa$ is finite and nonvanishing. In the limit $\kappa \to \infty$ all RDCAs are shown to ex…

Change-points detection for variance piecewise constant models

2011

A new approach based on the fit of a generalized linear regression model is introduced for detecting change-points in the variance of heteroscedastic Gaussian variables, with piecewise constant variance function. This approach overcome some limitations of both exact and approximate well-known methods that are based on successive application of search and tend to overestimate the real number of changes in the variance of the series. The proposed method just requires the computation of a gamma GLM with log-link, resulting in a very efficient algorithm even with large sample size and many change points to be estimated.

On the dimerization of the primitive tRNAs: implications in the origin of genetic code.

2002

RNAs that catalyse their own aminoacylation have been recently selected in vitro. These findings support the notion that the primitive aminoacyl-tRNA synthetases may have been RNAs. In this paper, we propose a structural model for the first aminoacyl-tRNA synthetase consisting of an RNA complex formed between two primitive tRNA molecules through two intermolecular loop-strand interactions, and with implications in the origin of the genetic code.

On the derivation of a linear Boltzmann equation from a periodic lattice gas

2004

We consider the problem of deriving the linear Boltzmann equation from the Lorentz process with hard spheres obstacles. In a suitable limit (the Boltzmann-Grad limit), it has been proved that the linear Boltzmann equation can be obtained when the position of obstacles are Poisson distributed, while the validation fails, also for the "correct" ratio between obstacle size and lattice parameter, when they are distributed on a purely periodic lattice, because of the existence of very long free trajectories. Here we validate the linear Boltzmann equation, in the limit when the scatterer's radius epsilon vanishes, for a family of Lorentz processes such that the obstacles have a random distributio…

A weighted combined effect measure for the analysis of a composite time-to-first-event endpoint with components of different clinical relevance

2018

Composite endpoints combine several events within a single variable, which increases the number of expected events and is thereby meant to increase the power. However, the interpretation of results can be difficult as the observed effect for the composite does not necessarily reflect the effects for the components, which may be of different magnitude or even point in adverse directions. Moreover, in clinical applications, the event types are often of different clinical relevance, which also complicates the interpretation of the composite effect. The common effect measure for composite endpoints is the all-cause hazard ratio, which gives equal weight to all events irrespective of their type …

Using Statistical and Computer Models to Quantify Volcanic Hazards

2009

Risk assessment of rare natural hazards, such as large volcanic block and ash or pyroclastic flows, is addressed. Assessment is approached through a combination of computer modeling, statistical modeling, and extreme-event probability computation. A computer model of the natural hazard is used to provide the needed extrapolation to unseen parts of the hazard space. Statistical modeling of the available data is needed to determine the initializing distribution for exercising the computer model. In dealing with rare events, direct simulations involving the computer model are prohibitively expensive. The solution instead requires a combination of adaptive design of computer model approximation…