Search results for "SIP"

Fetal Renal Effects of Intrauterine Diuretic Application in Wistar Rats

1987

The application of placenta-permeable diuretics in the pregnant woman has been the subject of controversial discussion (Friedberg 1980; Souster and Emery 1980). Not only is the fetus endangered by potential placental ischaemia, natrium and potassium loss and possible dehydration in the mother (Friedberg 1980; Gant and Madden 1975), but also induced effects on fetal organ formation should be considered (Frohneberg and Hutschenreiter 1982; Seufert 1986). Depending on the site of action and placental permeability, fetal urine production can be increased (Wladimiroff 1975), thus leading to consequences for the morphological and functional embryogenesis of isolated nephron sections (Frohneberg 1…

Myocardial Protection by Retrograde Cardioplegic Perfusion in the Presence of Acute Coronary Artery Obstruction: An Experimental Study

1992

To investigate retrograde delivery of cardioplegic solutions as a means of enhancing myocardial protection in the presence of coronary artery occlusion, a two-part experimental model was devised. In part 1 (in vitro) the possibility of retroperfusing the entire myocardium during acute occlusion of the left anterior descending artery (LAD) was assessed. In part 2 (in vivo) acute LAD occlusion was performed in dogs, and during 2 hours of aortic cross-clamping crystalline cardioplegic solution was infused at 20-minute intervals. In group I the infusion was antegrade, via the aortic root, and in group II it was retrograde, via the coronary sinus. Thereafter the LAD snare was released and the do…

Habenular effect on hippocampal excitability is not cholinergically-mediated.

1989

Modifications induced on the amygdaloid paroxysmal activity by entopeduncolar or nigral injection of kainic acid, in the cat.

1983

Entopeduncolar or nigral injection of kainic acid determines an early decrease of the evoked amygdaloid paroxysmal activity and a later increase of the after discharge duration. This biphasic effect is likely due to the structural analogy of the drug with monosodium glutamate, a neuroexcitant amino acid. The data suggest that the basal ganglia exert a tonic control on the amygdaloid activity.

Neuronal and extraneuronal uptake and efflux of catecholamines in the isolated rabbit heart

1974

1. Isolated rabbit hearts were perfused with (−)-noradrenaline, (−)-adrenaline and (±)-isoprenaline for various time periods (1–180 min) and then washed with an amine-free medium. The venous concentration of the amine was estimated fluorimetrically during the infusion and after its end, to study removal and efflux, respectively. 2. In untreated hearts and after pretreatment with reserpine the removal had a constant rate over 20–60 min. After pretreatment with pargyline to block monoamine oxidase (MAO), however, the removal of noradrenaline declined exponentially to zero. Inhibition of the neuronal uptake (desipramine) and chemical sympathectomy (6-hydroxydopamine) abolished the removal of n…

2015

Several point mutations have been identified in human aquaporins, but their effects on the function of the respective aquaporins are mostly enigmatic. We analyzed the impact of the aquaporin 2 mutation V71M, which causes nephrogenic diabetes insipidus in humans, on aquaporin structure and activity, using the bacterial aquaglyceroporin GlpF as a model. Importantly, the sequence and structure around the V71M mutation is highly conserved between aquaporin 2 and GlpF. The V71M mutation neither impairs substrate flux nor oligomerization of the aquaglyceroporin. Therefore, the human aquaporin 2 mutant V71M is most likely active, but cellular trafficking is probably impaired.

Gleichzeitiges Vorkommen von Diabetes mellitus, Diabetes insipidus, Opticusatrophie und Innenohrschwerh�rigkeit

1975

Report of a further case with coexisting diabetes mellitus, diabetes insipidus, optic atrophy und neurogenic deafness. It was not possible to find a cause for these symptoms. The cases reported in the literature are brought together and discussed.

Influence of induced intrauterine diuresis on the upper urinary tract

1993

There are many possible etiologies of sonographically detected dilatation of the renal pelvis and the ureter during pregnancy. The observation that fetal ureteral dilatation occurs with congenital diabetes insipidus has led to the suspicion of at least a modifying influence resulting from intrauterine diuresis. To increase fetal diuresis experimentally, Wistar rats were treated with 100 mg chlorthalidon and 40 mg furosemide per kg bodyweight per day. The animal experiment was performed with four groups. Group I was treated during the entire course of pregnancy. Group II during the first half and Group III during the second half. Group C was the untreated control group. For morphometric inve…

Characterization of endogenous noradrenaline release from intact and epithelium-denuded rat isolated trachea.

1991

1. Overflow of endogenous noradrenaline (NA) from the in vitro incubated rat trachea evoked by two periods of electrical field stimulation (S1, S2 at 3 or 15 Hz) or by high potassium (60 mM) was determined by high performance liquid chromatography (h.p.l.c.) with electrochemical detection. 2. In the presence of the neuronal uptake inhibitor desipramine, the alpha 2-adrenoceptor antagonist, yohimbine, enhanced the overflow of NA evoked by stimulation at 3 Hz by about 100% suggesting the presence of presynaptic inhibitory autoreceptors on the sympathetic nerves innervating the trachea. 3. When desipramine and yohimbine were present throughout the experiments, the overflow of NA evoked by the …

Indomethacin treatment in amphotericin B induced nephrogenic diabetes insipidus.

1994

Nephrogenic diabetes insipidus (NDI) is a serious side effect of various drugs. Elevated renal prostaglandin E2 levels have been found in patients with lithium-induced NDI and have been implicated in the pathogenesis. We report the case of a patient who developed NDI following treatment with amphotericin B. Prostaglandin levels were elevated. Indomethacin had an antidiuretic effect and normalized prostaglandin levels.