Search results for "SIPS"
showing 3 items of 3 documents
Role of p16INK4a and BMI-1 in oxidative stress-induced premature senescence in human dental pulp stem cells
2017
Human dental pulp stem cells (hDPSCs) are a source for cell therapy. Before implantation, an in vitro expansion step is necessary, with the inconvenience that hDPSCs undergo senescence following a certain number of passages, loosing their stemness properties. Long-term in vitro culture of hDPSCs at 21% (ambient oxygen tension) compared with 3–6% oxygen tension (physiological oxygen tension) caused an oxidative stress-related premature senescence, as evidenced by increased β-galactosidase activity and increased lysil oxidase expression, which is mediated by p16INK4a pathway. Furthermore, hDPSCs cultured at 21% oxygen tension underwent a downregulation of OCT4, SOX2, KLF4 and c-MYC factors, w…
L’opera del premio Nobel Giulio Natta fra le attività della Società Italiana per il Progresso delle Scienze (SIPS) e della Società Chimica Italiana (…
2013
In spite of its great historical and social-institutional importance, the Italian Society for the Progress of Sciences (SIPS) still have not that historical fame which it would deserve. This paper wishes to contribute to delineate a brief historic-critical account which may provide a coherent diachronic perspective in which historically laid out such an institution, highlighting the relevant load that it has had for the cultural, scientific and technological development of the post-Resurgence Italy. From this historical recognition, it will be then possible to descry a more or less direct role played by SIPS, around the first half of 20th Century, as concerns the research activity of the It…