Search results for "SLC"
showing 10 items of 61 documents
Rôle du transporteur d'acides aminés Minidiscs dans le fonctionnement du système nerveux chez Drosophila melanogaster
2015
Amino acids have many functions in the body in addition to their role as basic constituents of proteins. They can for example serve as a neurotransmitter or signal for the activation of intracellular pathways. Carriers of the SLC protein family facilitate their path through the plasma membrane. The heterodimeric amino acid transporters HAT belong to SLC proteins. HAT are composed of a light chain SLC7 ensuring the specificity of transport and a heavy chain SLC3 involved in the addressing of the protein complex to the plasma membrane. My thesis focused on studying the role of a SLC7 homologue in drosophila, Minidiscs (Mnd), in the functioning of the nervous system. Mnd might belong to system…
Measurements of the Lineshape of the $Z^{0}$ and Determination of Electroweak Parameters from its Hadronic and Leptonic Decays
1994
Abstract: During the LEP running periods in 1990 and 1991 DELPHI has accumulated approximately 450000 Z0 decays into hadrons and charged leptons. The increased event statistics coupled with improved analysis techniques and improved knowledge of the LEP beam energies permit significantly better measurements of the mass and width of the Z0 resonance. Model independent fits to the cross sections and leptonic forward-backward asymmetries yield the following Z0 parameters: the mass and total width M(Z) = 91.187 +/- 0.009 GeV, GAMMA(Z) = 2.486 +/- 0.012 GeV, the hadronic and leptonic partial widths GAMMA(had) = 1.725 +/- 0.012GeV, GAMMA(l) = 83.01 +/- 0.52 MeV, the invisible width GAMMA(inv) = 51…
Improved measurements of cross sections and asymmetries at the Z0 resonance
1994
During the 1992 running period of the LEP e+e- collider, the DELPHI experiment accumulated approximately 24 pb-1 of data at the Z0 peak. The decays into hadrons and charged leptons have been analysed to give values for the cross sections and leptonic forward-backward asymmetries which are significantly improved with respect to those previously published by the DELPHI collaboration. Incorporating these new data, more precise values for the Z0 resonance parameters are obtained from model-independent fits. The results are interpreted within the framework of the Standard Model, yielding for the top quark mass m(t) = 157(-48)+36(expt.)-20(+19)(Higgs) GeV, and for the effective mixing angle sin2 …
Prophylactic cranial irradiation in stage IV small cell lung cancer
2019
Background: Due to conflicting results between major trials the role of prophylactic cranial irradiation (PCI) in stage IV small cell lung cancer (SCLC) is controversial.Methods: We obtained a list of 13 European experts from both the European Society for Therapeutic Radiation Oncology (ESTRO) and the International Association for the Study of Lung Cancer (IASLC). The strategies in decision making for PCI in stage IV SCLC were collected. Decision trees were created representing these strategies. Analysis of consensus was performed with the objective consensus methodology.Results: The factors associated with the recommendation for the use of PCI included the fitness of the patient, young age…
285 DOWNREGULATION OF ORGANIC CATION TRANSPORTERS OCT1 (SLC22A1) AND OCT3 (SLC22A3) IN HUMAN HEPATOCELLULAR CARCINOMA AND THEIR PROGNOSTIC SIGNIFICAN…
2012
Background Organic cation transporters (OCT) are responsible for the uptake and intracellular inactivation of a broad spectrum of endogenous substrates and detoxification of xenobiotics and chemotherapeutics. The transporters became pharmaceutically interesting, because OCTs are determinants of the cytotoxicity of platin derivates and the transport activity has been shown to correlate with the sensitivity of tumors towards tyrosine kinase inhibitors. No data exist about the relevance of OCTs in hepatocellular carcinoma (HCC).
Cross-sections and leptonic forward-backward asymmetries from the Z(0) running of LEP
2000
During 1993 and 1995 LEP was run at 3 energies near the Z $^0$ peak in order to give improved measurements of the mass and width of the resonance. During 1994, LEP operated only at the Z $^0$ peak. In total DELPHI accumulated data corresponding to an integrated luminosity of approximately 116 pb $^{-1}$ . Analyses of the hadronic cross-sections and of the cross-sections and forward-backward asymmetries in the leptonic channels used the most precise evaluations of the LEP energies. In the dimuon channel, events with a photon radiated from the initial state have been used to probe the cross-sections and asymmetries down to PETRA energies. Model independent fits to all DELPHI lineshape and asy…
Measurements of the tau polarisation in Z0 decays
1995
A sample of Z0→τ+τ- events observed in the DELPHI detector at LEP in 1991 and 1992 is analysed to measure the τ polarisation in the exclusive decay channels {Mathematical expression}, {Mathematical expression}, πν, ρν and a1ν. The τ polarisation is also measured with an inclusive hadronic analysis which benefits from a higher efficiency and a better systematic precision than the use of the exclusive decay modes. The results have been combined with those published on the 1990 data. A measurement of the τ polarisation as a function of production angle yields the values for the mean τ polarisation 〈P〉τ=-0.148±0.022 and for the Z0 polarisation PZ=-0.136±0.027. These results are used to determin…
First Case Report of Primary Carnitine Deficiency Manifested as Intellectual Disability and Autism Spectrum Disorder
2019
Systemic primary carnitine deficiency (PCD) is a genetic disorder caused by decreased or absent organic cation transporter type 2 (OCTN2) carnitine transporter activity, resulting in low serum carnitine levels and decreased carnitine accumulation inside cells. In early life, PCD is usually diagnosed as a metabolic decompensation, presenting as hypoketotic hypoglycemia, Reye syndrome, or sudden infant death; in childhood, PCD presents with skeletal or cardiac myopathy. However, the clinical presentation of PCD characterized by autism spectrum disorder (ASD) with intellectual disability (ID) has seldom been reported in the literature. In this report, we describe the clinical features of a sev…
CYP3A5*3 and CYP2C8*3 variants influence exposure and clinical outcomes of tacrolimus-based therapy
2020
Aim: The influence of variants in pharmacokinetics-related genes on long-term exposure to tacrolimus (TAC)-based therapy and clinical outcomes was investigated. Patients & methods: Brazilian kidney recipients were treated with TAC combined with everolimus (n = 178) or mycophenolate sodium (n = 97). The variants in CYP2C8, CYP2J2, CYP3A4, CYP3A5, POR, ABCB1, ABCC2, ABCG2, SLCO1B1 and SLCO2B1 were analyzed. Main results: CYP3A5*3/*3 genotype influenced increase in TAC concentration from week 1 to month 6 post-transplantation (p < 0.05). The living donor and CYP2C8*3 variant were associated with reduced risk for delayed graft function (OR = 0.07; 95% CI = 0.03–0.18 and OR = 0.45; 95% C…
Calculation of the two-loop heavy-flavor contribution to Bhabha scattering
2008
We describe in detail the calculation of the two-loop corrections to the QED Bhabha scattering cross section due to the vacuum polarization by heavy fermions. Our approach eliminates one mass scale from the most challenging part of the calculation and allows us to obtain the corrections in a closed analytical form. The result is valid for arbitrary values of the heavy fermion mass and the Mandelstam invariants, as long as s,t,u >> m_e^2.