Search results for "SLI"
showing 10 items of 1729 documents
Oksidatīvās fosforilēšanas sistēmas funkcionalitātes novērtēšana, izmantojot citoplazmātisko hibrīdu šūnu modeļus
2020
Mitohondriju iekšējā membrānā ir izvietoti pieci enzīmu kompleksi, kas veido oksidatīvās fosforilēšanas (OXPHOS) sistēmu. OXPHOS sistēma saražo līdz pat 90% adenozīntrifosfāta šūnās. Mitohondriālās DNS (mtDNS) mutāciju izraisīti traucējumi OXPHOS sistēmā var izraisīt smagas mitohondriālās slimības. Mitohondriālo slimību diagnosikā nav vienas konkrētas metodes. Patogēno mtDNS mutāciju ietekmi var pētīt izmantojot citoplazmatisko hibrīdu šūnu modeļus. Darba mērķis ir novērtēt OXPHOS funkcionalitāti citoplazmatisko hibrīdu šūnu līniju kontroles grupā un pacienta šūnu līnijā ar iespējami patogēnu mtDNS mutāciju. Tika izveidota šūnu līniju kontroles grupa un noteiktas OXPHOS enzīmu aktivitātes, …
State feedback control against sensor faults for Lipschitz nonlinear systems via new sliding mode observer techniques
2011
This paper investigates the problem of simultaneous state and fault estimation and observer-based fault tolerant controller design for Lipschitz nonlinear systems with sensor failure. A new estimation technique is presented in this paper to deal with this design problem. In the proposed approaches, the original system is first augmented by a descriptor model transformation, then a new Proportional and Derivative sliding mode observer technique is developed to obtain accurate estimations of both system states and sensor faults. The designing observer is generalized from the PD observer in [3], but is not a trivial extension. Based on the state estimates, a observer-based control strategy is …
2014
State estimation problem is considered for a kind of wireless network control system with stochastic uncertainty and time delay. A sliding mode observer is designed for the system under the situation that no missing measurement occurs and system uncertainty happens in a stochastic way. The observer designed for the system can guarantee the system states will be driven onto the sliding surface under control law, and the sliding motion of system states on sliding surface will be stable. By constructing proper Lyapunov-Krasovskii functional, sufficient conditions are acquired via linear matrix inequality. Finally, simulation result is employed to show the effectiveness of the proposed method.
A sliding mode approach to H∞ non-fragile observer-based control design for uncertain Markovian neutral-type stochastic systems
2015
This paper is focused on designing an H ∞ sliding-mode control for a class of neutral-type stochastic systems with Markovian switching parameters and nonlinear uncertainties. An H ∞ non-fragile observer subjected to the transition rates of the switching mode is firstly constructed. By some specified matrices, the connections among the designed sliding surfaces corresponding to every mode are established. Then, the state-estimation-based sliding mode control law is designed to guarantee the reachability of the sliding surface in finite time interval. Furthermore, a stochastic stability criterion is established for all admissible uncertainties, which can guarantee the error system and sliding…
Comment on "Displacement along the Karakoram fault, NW Himalaya, estimated from LA-ICP-MS U Pb dating of offset geologic markers" published by Shifen…
2013
International audience; Field evidence for syn-deformation migmatization and crystallization along the Karakorum fault contradicts the study of Wang et al. (2012). The ages of such magmatic rocks provide minimum ages for the onset of deformation at similar to 23 Ma in North Ayilari and similar to 19 Ma in Tangtse. The onset of deformation at 12 Ma in the Ayilari range inferred by Wang et al. (2012) from a muscovite Ar/Ar age is a cooling age, thus only a minimum age. The similar to 60 Ma granodiorite bodies, the ophiolitic rocks and the south Kailash thrust that are correlated across the fault to provide a 52 +/- 2 km finite offset do not define reliable piercing points. Such observations a…
Circulating leukocyte telomere length and oxidative stress: A new target for statin therapy
2011
International audience; Objectives: We investigated the relationship between prior statin therapy and leukocyte telomere length (LTL), as well as their interaction with potential new biomarkers of oxidative deoxyribonucleic acid (DNA) lesions and reactive oxygen species-induced inflammation.Methods and results: From patients admitted for an acute myocardial infarction, LTL was assessed by quantitative polymerase chain reaction (Q-PCR), and leukocyte Finkel-Biskis-Jinkins osteosarcoma (FOS) and 8-oxoguanine DNA glycosylase (OGG1) messenger ribonucleic acid (mRNA) levels were measured by retrotranscription Q-PCR. Patients under prior chronic statin therapy were compared with patients without …
Endocrine side-effects of new anticancer therapies: Overall monitoring and conclusions
2018
IF 0.795 (2017); International audience; The present final consensus statement of the French Society of Endocrinology lays out the assessments that are to be systematically performed before and during anticancer treatment by immunotherapy, tyrosine kinase inhibitors or mTOR inhibitors, even without onset of any endocrinopathy. It also discusses the CTCAE adverse event grading system in oncology and the difficulty of implementing it for endocrine side-effects of these anticancer treatments. Notably, this is why certain treatment steps applied in other side-effects (e.g., high-dose corticosteroids, contraindications to immunotherapy, etc.) need to be discussed before implementation for endocr…
Corrigendum to “Registration of surfaces minimizing error propagation for a one-shot multi-slit hand-held scanner” [Pattern Recognition 41 (6) 2055–2…
2009
Direktīvas 2004/35/EK ieviešanas problēmas Latvijā: fizisko personu un operatora atbildības praktiskie aspekti un būtiskuma slieksnis
2019
Ņemot vērā vides atbildības korektas piemērošanas nozīmi mūsdienu situācijā, darba mērķis ir izvērtēt Direktīvas 2004/35/EK ieviešanas problemātiku Latvijā saistībā ar atbildības subjektu un būtiskuma slieksni. Tādējādi darba uzdevums ir sākotnēji izpētīt Direktīvas 2004/35/EK izpratni Latvijas tiesību sistēmā, analizējot tās materiāltiesisko, personu un laika tvēruma robežas. Tālākajā darba gaitā tiek aplūkoti ar direktīvu ieviestie jauninājumi Latvijas vides tiesību jomā salīdzinājumā ar iepriekš pastāvošo regulējumu. Darba praktiskajā daļā tiek turpmāk izvērsta operatora tiesiskā regulējuma attiecināšana uz fizisku personu, kā arī būtiskuma sliekšņa problemātika. Secināms, ka Latvija dir…
Acs refrakcija un viņas noteikšana
1933
Titullapā norādīts autors: Apiņš, Kārlis