Search results for "SOA"
showing 10 items of 246 documents
Cláusulas de processamento de dados pessoais inseridas nos contratos de adesão: a falta de autonomia e liberdade na expressão da vontade e vias de pr…
2022
A contratação em massa hodierna revela-se inseparável das cláusulas de processamento de dados pessoais, as quais, inelutavelmente, integram os clausulados destes contratos de adesão padronizados, celebrados com recurso a cláusulas contratuais gerais. Assim, à posição, por natureza frágil, de aderente destes contratos, soma-se a de titular de dados pessoais objeto de processamento(s), cuja esfera jurídica pessoal, em particular, a sua vida privada e familiar, e por vezes até intimidade, pode conhecer intromissões com a aceitação das referidas cláusulas. Sendo o consentimento do titular um dos fundamentos de licitude para o tratamento de dados pessoais, nos termos do artigo 6.º/1/a) do Regula…
Salmon lice in the Pacific Ocean show evidence of evolved resistance to parasiticide treatment
2022
AbstractParasitic salmon lice (Lepeophtheirus salmonis) threaten the economic and ecological sustainability of salmon farming, and their evolved resistance to treatment with emamectin benzoate (EMB) has been a major problem for salmon farming in the Atlantic Ocean. In contrast, the Pacific Ocean, where wild salmon are far more abundant, has not seen widespread evolution of EMB-resistant lice. Here, we use EMB bioassays and counts of lice on farms from the Broughton Archipelago, Canada—a core region of salmon farming in the Pacific—to show that EMB sensitivity has dramatically decreased since 2010, concurrent with marked decrease in the field efficacy of EMB treatments. Notably, these bioass…
Chromogranin A in the Mammalian Merkel Cell: Cellular and Subcellular Distribution
1989
Chromogranin-A (CGA), which accounts for more than half the soluble matrix protein in secretory granules of various neuroendocrine cells, has a wide spectrum of potential biological roles and is considered an important marker of the diffuse neuroendocrine system (DNES). Light and electron microscopic immunohistochemistry of mammalian skin revealed that Merkel cells are exclusively CGA-immunoreactive (ir) and that the immunoreaction is localized in the secretory granules. This finding supports the classification of the Merkel cell as a member of the DNES. The CGA immunoreactivity was restricted to Merkel cells of pigs and humans. In human embryonic skin, CGA was expressed in Merkel cells as …
Expression and regulation of mPer1 in immortalized GnRH neurons.
2003
Hypothalamic GnRH (gonadotropin-releasing hormone) neurons play a critical role in the initiation and maintenance of reproduction competence. Using the mouse GnRH neuronal cell line, GT1-7, we have characterized the expression of the gene mPer1, a recognized key element of the mammalian circadian clockwork. Both mPer1 transcripts and the 136 kDa mPER1 gene product could be detected in these cells. Immunocytochemical analysis also confirmed expression of mPER1 both in vitro and in vivo in GnRH neurons. Activation of cyclic AMP signalling pathways in vitro elevated GnRH secretion as well as mPer1 expression and nuclear mPER1 immunoreactivity. As mPER1 is known to feedback on transcriptional a…
GLP-2 receptor expression in excitatory and inhibitory enteric neurons and its role in mouse duodenum contractility
2011
Background Glucagon-like peptide 2 (GLP-2), a nutrient-responsive hormone, exerts various actions in the gastrointestinal tract that are mediated by a G-protein coupled receptor called GLP-2R. A little information is available on GLP-2R expression in enteric neurons and nothing on the interstitial cells of Cajal (ICC). Methods We investigated presence and distribution of the GLP-2R in the mouse duodenum by immunohistochemistry and the potential motor effects of GLP-2 on the spontaneous and neurally evoked mechanical activity. Key Results The GLP-2R was expressed by the myenteric and submucosal neurons. Labelling was also present in nerve varicosities within the circular muscular layer an…
Regulation of serotonin release from the intestinal mucosa.
1991
Summary In the mammalian intestine serotonin (5-hydroxytryptamine, 5-HT) is present in high concentrations in the enterochromaffin cells. The release of 5-HT from the intestinal mucosa is regulated by a complex pattern of neuronal and humoral inputs to the enterochromaffin cells. The enterochromaffin cells appear to be endowed with different inhibitory ( α 2 -adrenoceptors, GABA A - and GABA B -receptors, histamine H 3 -receptors, receptors for vasoactive intestinal polypeptide and somatostatin) as well as stimulatory receptors ( β -adrenoceptors, muscarine and nicotine receptors). The physiological significance of this complex system of receptors is suggested by experiments which demonstra…
Paracrine roles of extracellular vesicles released by mouse mesoangioblasts
2017
Extracellular vesicles (EV) represent an important mediator of cell-to-cell communication and are involved in both autocrine and paracrine signaling, with a critical role in a number of physiological and pathological conditions.1 The bioactive molecules contained within EV simultaneously activate several different pathways resulting in the synergistic stimulation of target cells. The discovery and characterization of EV have added a novel understanding to regenerative medicine, namely the finding that stem cells are an abundant source of EV.1-2 A6 mouse mesoangioblasts, vessel-associated multipotent progenitor stem cells that are capable of differentiating into different mesodermal cell typ…
High-temperature metamorphism and crustal melting at ca. 3.2 Ga in the eastern Kaapvaal craton, southern Africa
2018
Abstract The question of whether high-grade metamorphism and crustal melting in the early Archaean were associated with modern-style plate tectonics is a major issue in unravelling early Earth crustal evolution, and the eastern Kaapvaal craton has featured prominently in this debate. We discuss a major ca. 3.2 Ga tectono-magmatic-metamorphic event in the Ancient Gneiss Complex (AGC) of Swaziland, a multiply deformed medium- to high-grade terrane in the eastern Kaapvaal craton consisting of 3.66–3.20 Ga granitoid gneisses and infolded greenstone remnants, metasedimentary assemblages and mafic dykes. We report on a 3.2 Ga granulite-facies assemblage in a metagabbro of the AGC of central Swazi…
An anthracological approach to understanding Late Classic period cultural collapse in Mesoamerica’s northwestern frontier
2012
International audience; For over 50 years, researchers have suggested that increased regional rainfall over the highland deserts of Mesoamerica's northwestern frontier zone during the Classic period (AD 200-900) allowed for the colonization of the zone by farming groups who originated from Central and/or West Mexico. A severe and prolonged drought is hypothesized to have later provoked the abandonment of the region by these sedentary populations by AD 900. However, very little research has been carried out in the zone to detect evidence of this proposed climate change. I present results from the first systematic study of wood charcoal from the northwestern frontier, comparing the data from …
Anomalous performance enhancement effects in Ruthenium-based Dye Sensitized Solar Cells
2017
Dye Sensitized Solar Cells (DSSCs) are nowadays more and more employed since they present lower production costs than traditional silicon photovoltaic devices. An interesting phenomenon affecting such devices consists in the fact that current density-voltage (J-V) characteristic can depend on the history of the cell prior to the measurement, which often can be assimilated to an anomalous hysteresis effect. In this work, we study such phenomenon on Ruthenium-based DSSCs through a series of measurements performed after applying different values of external electrical field to the cell. The measurements have been carried out both under simulated sunlight (AM1.5G - 1000 W/m2) and in the dark. W…