Search results for "SOA"
showing 10 items of 246 documents
CD4(+) and CD8(+) anergic T cells induced by interleukin-10-treated human dendritic cells display antigen-specific suppressor activity.
2002
Interleukin-10 (IL-10)–treated dendritic cells (DCs) induce an alloantigen- or peptide-specific anergy in various CD4+ and CD8+ T-cell populations. In the present study, we analyzed whether these anergic T cells are able to regulate antigen-specific immunity. Coculture experiments revealed that alloantigen-specific anergic CD4+ and CD8+ T cells suppressed proliferation of syngeneic T cells in a dose-dependent manner. The same effect was observed when the hemagglutinin-specific CD4+T-cell clone HA1.7 or tyrosinase-specific CD8+ T cells were cocultured with anergic T cells of the same specificity. Anergic T cells did not induce an antigen-independent bystander inhibition. Suppression was depe…
VIP-containing deep short-axon cells of the olfactory bulb innervate interneurons different from granule cells
2003
This study investigates the targets of the population of vasoactive intestinal polypeptide (VIP)-containing deep short-axon cells of the rat olfactory bulb (OB), combining single- and double-immunocytochemical approaches under light and electron microscopy. It has been assumed that deep short-axon cells innervate granule cells in the mammalian OB, but their synaptic connectivity has not been demonstrated to date. Our results indicate that, instead of the accepted scheme of the bulbar circuitry, VIP-containing deep short-axon cells are gamma-aminobutyric acid (GABA)ergic interneurons specialized in the selective innervation of other GABAergic deep short-axon cells. Their axons contact with t…
Characterisation of tumour-associated antigens in colon cancer.
2002
In order to search for clinically relevant cancer-associated genes and to define further the spectrum of immunogenic proteins, we applied SEREX (serological identification of antigens by recombinant expression cloning) to analyse genes expressed in colon adenocarcinoma. Eight different serum-reactive cDNA clones were isolated by immunoscreening from a colon cancer-derived cDNA expression library. mRNA expression studies showed that 2 of them, RHAMM and AD034, have a differential tissue distribution, and that 3 genes, NAP1L1, RHAMM and AD034, are overexpressed in tumours in comparison with the adjacent non-cancerous tissues. 5' RLM-RACE analysis of AD034, a sequence with a tyrosine kinase mo…
Retention of aroma compounds in starch matrices: competitions between aroma compounds toward amylose and amylopectin
2002
International audience; The retention of three aroma compounds-isoamyl acetate, ethyl hexanoate, and linalool--from starch-containing model food matrices was measured by headspace analysis, under equilibrium conditions. We studied systems containing standard or waxy corn starch with one or two aroma compounds. The three studied aroma compounds interact differently: ethyl hexanoate and linalool form complexes with amylose, and isoamyl acetate cannot. However, in systems containing one aroma compound, we observed with both starches a significant retention of the three molecules. These results indicate that amylopectin could play a role in the retention of aroma. In systems containing two arom…
Stress response in mesoangioblast stem cells
2006
Stem cells are presumed to survive various stresses, since they are recruited to areas of tissue damage and regeneration, where inflammatory cytokines and cytotoxic cells may result in severe cell injury. We explored the ability of mesoangioblasts to respond to different cell stresses such as heat, heavy metals and osmotic stress, by analyzing heat shock protein (HSP)70 synthesis as a stress indicator. We found that the A6 mesoangioblast stem cells constitutively synthesize HSP70 in a heat shock transcription factor (HSF)-independent way. However, A6 respond to heat shock and cadmium treatment by synthesizing HSP70 over the constitutive expression and this synthesis is HSF1 dependent. The e…
Influence of the food matrix structure on the retention of aroma compounds.
2000
The retention of the aroma compounds in a multicomponent medium like the food matrix is influenced by their affinity with the protein when lipid is present at a low level (0.5%). The effect of the structure of the media is also studied by using two media with the same composition; one was emusified, and the other was not. Among the studied aroma compounds, 2-nonanone and isoamyl acetate present opposite behaviors: the volatility of isoamyl acetate is not affected by the change of the medium structure whereas that of 2-nonanone increases. The decrease of retention of 2-nonanone in an emulsified system would be due to a modification of the fixation site for this compound on the protein or to …
Increasing the levels of 2-phenylethyl acetate in wine through the use of a mixed culture of Hanseniaspora osmophila and Saccharomyces cerevisiae
2009
The impact of mixed cultures of Hanseniaspora osmophila and Saccharomyces cerevisiae with different initial yeast ratios on wine composition has been examined. The mixed culture significantly affected sugar consumption, the main enological parameters and ester concentrations, with the exception of glycerol, isoamyl acetate and diethyl succinate levels. Remarkably, in wines obtained with mixed cultures the concentration of 2-phenylethyl acetate was approximately 3- to 9-fold greater than that produced by S. cerevisiae pure culture. Moreover sensory evaluation revealed a stronger fruity character in wines fermented with mixed cultures than in control wines. Independently of the mixed culture …
Evaluation of Ensemble Machine Learning Methods in Mobile Threat Detection
2017
The rapid growing trend of mobile devices continues to soar causing massive increase in cyber security threats. Most pervasive threats include ransom-ware, banking malware, premium SMS fraud. The solitary hackers use tailored techniques to avoid detection by the traditional antivirus. The emerging need is to detect these threats by any flow-based network solution. Therefore, we propose and evaluate a network based model which uses ensemble Machine Learning (ML) methods in order to identify the mobile threats, by analyzing the network flows of the malware communication. The ensemble ML methods not only protect over-fitting of the model but also cope with the issues related to the changing be…
Concepções pessoais de inteligência e auto-estima: que diferenças entre estudantes portuguese e italianos?
2004
Neste artigo apresentam-se alguns dos resultados de um estudo intercultural sobre as concepções pessoais de inteligência e a auto-estima global, comparando alunos de dois níveis de ensino (secundário e superior) de Portugal e de Itália. A amostra total compreende 1540 alunos, 811 italianos e 729 portugueses, de ambos os sexos e de diferentes níveis sócio-económicos, frequentando os 10.º e o 12.º anos do ensino secundário e o 1.º ano de vários cursos universitários em ambos os países. Os instrumentos utilizados foram a Escala de Con- 763 cepções Pessoais de Inteligência (Faria, 2003), com 26 itens, e a Escala de Auto-Estima Global (Rosenberg, 1965), com 10 itens, traduzidas e adaptadas para …
Una postilla su una delle novità introdotte dall’art. 84 del codice dei contratti pubblici (d.lgs. n. 50/2016). L’obbligo delle stazioni appaltanti d…
2016
A NOTE ON ONE OF THE NEW MEASURES INTRODUCED BY ARTICLE 84 OF THE ITALIAN PUBLIC PROCUREMENTS CODE (LEGISLATIVE DECREE NO 50/2016). THE OBLIGATION OF CONTRACTING AUTHORITIES TO VERIFY THE QUALIFICATION CERTIFICATE OF CONTRACTORS ISSUED BY SOA Article 84 of the new Italian Public Procurements Code, which (along with other provisions) sets out the qualification system for economic operators offering the execution of works for an amount equal to or over 150,000 Euro, introduces several new provisions. In addition to the widely publicised and certainly significant one attributing broad regulatory powers to ANAC (the Italian Independent Authority supervising public procurements), Article 84 impo…