Search results for "SOLVENT"

showing 10 items of 1395 documents

Density Functional Theory Study of the Trans-Trans-Cis (TTC)→Trans-Trans-Trans (TTT) Isomerization of a Photochromic Spiropyran Merocyanine

2008

Density Functional Theory (DFT) calculations have been performed on the TTC→TTT isomerization reaction of the open forms of the 1',3'-dihydro-8-bromo-6-nitro- 1',3',3'-trimethylspiro[2H-1-benzopyran-2,2'-(2H)indole (8-Br-6-nitro-BIPS) system. The calculations were carried out in vacuo and in methylene chloride solution at different temperatures. Results are compared with the available experimental values of free energy difference and activation energy in solution.

Models MolecularIndolesVacuumSpiropyran; photochromism; DFT calculation; solvent influence on activation energy; merocyanine.merocyaninesolvent influence on activation energyPharmaceutical ScienceDFT calculationPyrimidinonesPhotochemistryArticleAnalytical Chemistrylcsh:QD241-441Photochromismchemistry.chemical_compoundlcsh:Organic chemistryDrug DiscoveryBenzopyransMerocyaninePhysical and Theoretical ChemistryMethyleneFluorescent DyesIndole testSpiropyranMethylene ChlorideOrganic ChemistryStereoisomerismModels TheoreticalNitro CompoundsphotochromismSolutionschemistrymerocyanine.Chemistry (miscellaneous)ThermodynamicsMolecular MedicineDensity functional theorySpiropyranIsomerizationCis–trans isomerismMolecules
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Electrical Conductivity and Luminescence in Coordination Polymers Based on Copper(I)-Halides and Sulfur-Pyrimidine Ligands

2011

The solvothermal reactions between pyrimidinedisulfide (pym(2)S(2)) and CuI or CuBr(2) in CH(2)Cl(2):CH(3)CN lead to the formation of [Cu(11)I(7)(pymS)(4)](n) (pymSH = pyrimidine-2(1H)-thione) (1) and the dimer [Cu(II)(μ-Br)(Br)L](2) (L = 2-(pyrimidin-2-ylamino)-1,3-thiazole-4-carbaldehyde) (2). In the later reaction, there is an in situ S-S, S-C(sp(2)), and C(sp(2))-N multiple bond cleavage of the pyrimidinedisulfide resulting in the formation of 2-(pyrimidin-2-ylamino)-1,3-thiazole-4-carbaldehyde. Interestingly, similar reactions carried out just with a change in the solvent (H(2)O:CH(3)CN instead of CH(2)Cl(2):CH(3)CN) give rise to the formation of coordination polymers with rather diffe…

Models MolecularLuminescencePyrimidinePolymersDimerInorganic chemistryElectric ConductivityHalidechemistry.chemical_elementSulfidesCrystallography X-RayLigandsSulfurCopperInorganic ChemistrySolventchemistry.chemical_compoundPyrimidineschemistryCoordination ComplexesPolymer chemistryPhysical and Theoretical ChemistryLuminescenceCopperBond cleavageInorganic Chemistry
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The synthesis, structure and properties of N-acetylated derivatives of ethyl 3-amino-1H-pyrazole-4-carboxylate.

2007

Ethyl 3-amino-1H-pyrazole-4-carboxylate (1) was yielded through total synthesis and reacted with acetic anhydride to give the acetylated products 2-6. Compounds 1-6 were studied with HPLC, X-ray, FT-IR, (1)H-NMR, (13)C-NMR and MS. Acetylation was carried out in solvents of various polarity, namely; chloroform; dioxane; DMF; acetic anhydride, at room temperature and at boiling points; and in the presence and absence of DMAP. The acetylated products are mainly nitrogen atoms in the ring. The position of the ring proton in the solution was based on NOESY; multinuclear HMBC, HSQC spectra and calculations. For equivalent amounts (1-1.5 mol) of acetic anhydride at room temperature two products of…

Models MolecularMagnetic Resonance Spectroscopy13C-NMR spectraAcetic AnhydridesRing (chemistry)Crystallography X-RayCatalysisCatalysischemistry.chemical_compoundDrug DiscoverySpectroscopy Fourier Transform InfraredOrganic chemistry4-AminopyridineFT-IR spectraChromatography High Pressure Liquidhetareneamino acidChloroformTemperatureTotal synthesisAcetylationGeneral ChemistryGeneral MedicineNuclear magnetic resonance spectroscopyhydrogen bondingSolventAcetic anhydridechemistry1H-NMR spectraDimethylformamidePyrazolesIndicators and ReagentsChromatography Thin LayerChemicalpharmaceutical bulletin
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What is the form of muscimol from fly agaric mushroom (Amanita muscaria) in water? An insight from NMR experiment supported by molecular modeling.

2020

ARTYKUŁ Z BADAŃ SPECJALNYCH

Models MolecularMagnetic Resonance SpectroscopyAmanita010402 general chemistry01 natural scienceschemistry.chemical_compoundReceptors GABAComputational chemistryMoleculeHumansGeneral Materials ScienceGABA-A Receptor Antagonistsindirect spin‐spin coupling constantsNMR in waterDensity Functional TheoryCarbon Isotopesbiology010405 organic chemistryAgaricmolecular modelingMuscimolChemical shiftWaterGeneral ChemistryCarbon-13 NMRbiology.organism_classification0104 chemical sciencesSolventnervous systemchemistryMuscimolGIAO NMRZwitterionProtonsAmanita muscariaMagnetic resonance in chemistry : MRCREFERENCES
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Fluorescent substituted amidines of benzanthrone: synthesis, spectroscopy and quantum chemical calculations.

2012

Abstract Several new substituted amidine derivatives of benzanthrone were synthesized by a condensation reaction from 3-aminobenzo[de]anthracen-7-one and appropriate aromatic and aliphatic amides. The obtained derivatives have a bright yellow or orange fluorescence in organic solvents and in solid state. The novel benzanthrone derivatives were characterized by TLC analysis, 1H NMR, IR, MS, UV/vis, and fluorescence spectroscopy. The solvent effect on photophysical behaviors of these dyes was investigated, and the results showed that the Stoke’s shift increased, whereas quantum yield decreased with the growth of the solvent polarity. The structure of some dyes was confirmed by the X-ray singl…

Models MolecularMagnetic Resonance SpectroscopyChemistryAmidinesQuantum yieldPhotochemistryCrystallography X-RayAtomic and Molecular Physics and OpticsFluorescence spectroscopyBenzanthroneAnalytical ChemistryAmidinechemistry.chemical_compoundSpectrometry FluorescenceSpectroscopy Fourier Transform InfraredProton NMRBenz(a)AnthracenesZINDOSpectrophotometry UltravioletSolvent effectsSpectroscopyInstrumentationSpectroscopyFluorescent DyesSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy
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Backbone dynamics of rusticyanin: the high hydrophobicity and rigidity of this blue copper protein is responsible for its thermodynamic properties.

2003

Local dynamics and solute-solvent exchange properties of rusticyanin (Rc) from Thiobacillus ferrooxidans have been studied by applying heteronuclear ((1)H, (15)N) NMR spectroscopy. (15)N relaxation parameters have been determined for the reduced protein, and a model-free analysis has been applied. The high average value of the generalized order parameter, S(2) (0.93), indicates that Rc is very rigid. The analysis of cross correlation rates recorded in both the reduced and the oxidized forms conclusively proves that Rc possesses the same dynamic features in both oxidation states. The accessibility of backbone amide protons to the solvent at different time scales has also been studied by appl…

Models MolecularMagnetic Resonance SpectroscopyCopper proteinWaterNuclear magnetic resonance spectroscopyThiobacillusBiochemistryProtein Structure SecondaryProtein Structure TertiarySolventMetalchemistry.chemical_compoundCrystallographyProtein structureHeteronuclear moleculechemistryBacterial ProteinsAzurinvisual_artAmideRusticyaninvisual_art.visual_art_mediumThermodynamicsHydrophobic and Hydrophilic InteractionsCopperBiochemistry
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Effects of static and dynamic perturbations on isotropic hyperfine coupling constants in some quinone radicals.

2004

The effects of solvent dielectric response on the isotropic hyperfine coupling constants of the 1,4-benzoquinone, 1,4-naphthoquinone and 9,10-anthraquinone anions and 1,4-naphthalenediol cation radicals were studied by electron spin resonance (ESR) spectroscopy and by the theoretical density functional method within the polarizable continuum model. Experimental results demonstrate that the isotropic hyperfine coupling constants can be obtained with high accuracy and that the effects of solvent impurities can be minimized by careful sample preparation. The results obtained correlate well with theoretical predictions from density functional theory calculations. For 1,4-naphthalenediol both th…

Models MolecularMagnetic Resonance SpectroscopyFree RadicalsRadicalMolecular ConformationPolarizable continuum modelMolecular physicsSensitivity and Specificitylaw.inventionlawImpurityComputational chemistryElectric ImpedanceGeneral Materials ScienceComputer SimulationSpectroscopyElectron paramagnetic resonanceBinding SitesChemistryIsotropyQuinonesReproducibility of ResultsGeneral ChemistrySolventKineticsSolventsAnisotropyDensity functional theoryArtifactsMagnetic resonance in chemistry : MRC
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Factors Governing the Chemical Stability and NMR Parameters of Uracil Tautomers and Its 5-Halogen Derivatives

2020

We report on the density functional theory (DFT) modelling of structural, energetic and NMR parameters of uracil and its derivatives (5-halogenouracil (5XU), X = F, Cl, Br and I) in vacuum and in water using the polarizable continuum model (PCM) and the solvent model density (SMD) approach. On the basis of the obtained results, we conclude that the intramolecular electrostatic interactions are the main factors governing the stability of the six tautomeric forms of uracil and 5XU. Two indices of aromaticity, the harmonic oscillator model of aromaticity (HOMA), satisfying the geometric criterion, and the nuclear independent chemical shift (NICS), were applied to evaluate the aromaticity of ur…

Models MolecularMagnetic Resonance SpectroscopyNICSsolvent stabilizationMolecular ConformationPharmaceutical SciencePolarizable continuum modelDFTArticleAnalytical Chemistrylcsh:QD241-441tautomersHalogenslcsh:Organic chemistryComputational chemistryDrug DiscoveryHOMAPhysical and Theoretical ChemistryUracilDensity Functional TheoryBasis setMolecular Structure5-halogenouracil (5XU)ChemistryChemical shiftOrganic ChemistryAromaticityaromaticityTautomerChemistry (miscellaneous)Intramolecular forceSolventsMolecular MedicineChemical stabilityDensity functional theoryMolecules
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Self-assembly of programmed building blocks into structurally uniform dendrimers.

2005

Selective and independent dimerization of tri- and tetraurea derivatives was used to build up dendritic assemblies which are uniform in size and structure. Dendrimers with the total molecular masses of about 25 000 g/mol were obtained. The existence of uniform assemblies was proved by 1H and 1H DOSY NMR experiments and also by dynamic light scattering.

Models MolecularMagnetic Resonance SpectroscopyStereochemistryChemistryOrganic solventMolecular ConformationHydrogen BondingGeneral ChemistryBiochemistrySolution structureCatalysisMolecular aggregationCrystallographyColloid and Surface ChemistryDynamic light scatteringPhenolsDendrimerCalixareneUreaSelf-assemblyCalixarenesJournal of the American Chemical Society
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Synthesis, characterisation and crystal structures of Schiff bases from the reaction of 4,6-O-ethylidene-β-D-glucopyranosylamine with substituted sal…

2001

Multiple chemical modifications were carried out on D-glucose to result in the corresponding Schiff bases. Such modifications performed on D-glucose not only helped in increasing the solubility of the products in nonaqueous solvents, but also restricted the anomerisation of the saccharide moiety in solution. NMR study of the products revealed the presence of the β-anomeric form of the saccharide moiety in Me2SO solution. All the compounds were characterised by analytical and spectral methods. The literature is devoid of any crystal structures of saccharide–Schiff base combinations of the type reported in this paper. The crystal structures of these molecules exhibited a tridentate, ONO bindi…

Models MolecularMagnetic Resonance SpectroscopyStereochemistryNuclear Magnetic ResonanceCyclohexane conformationStereoisomerismCrystal structureCrystallography X-RayBiochemistryHeterocyclic Compounds 2-RingAnalytical ChemistrySpectroscopy Fourier Transform InfraredCarbohydrate ConformationMoleculeMoietySolubilitySchiff BasesAldehydesGlucosamineChemistryHydrogen bondOrganic CompoundsOrganic ChemistryHydrogen BondingStereoisomerismGeneral MedicineNuclear magnetic resonance spectroscopyCrystallographyGlucoseSolubilitySpectrophotometryCrystal StructureSolventsIndraStra Global
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