Search results for "SOM"
showing 10 items of 8346 documents
No zoba pulpas cilmes šūnas izolētas eksosoma ievadītas intranazāli protektē dopamīnerģiskos neironus 6-OHDA izraisītā Pārkinsona slimības modelī žur…
2018
Pārkinsona slimība (PS) ir viena no visbiežāk sastopamajām neirodeģeneratīvajām saslimšanām, kurai joprojām nav atrasta efektīva medikamentoza terapija. Slimnieku skaits ar katru gadu pieaug, jo aizvien ir apgrūtināta savlaicīga slimības diagnosticēšana un ārstēšana. Pirmos PS simptomus novēro, kad lielākajā smadzeņu daļā jau ir notikusi dopamīnerģisko neironu atrofija. Darba mērķis bija noskaidrot eksosomu protekciju uz dopamīnerģiskajiem neironiem un to ietekmi uz motorajiem traucējumiem un salīdzināt kā no zoba pulpas cilmes šūnā iegūtas eksosomas spēj protektēt neirotoksīna 6-OHDA izraisītus bojājumus žurku smadzenēs. noskaidrot vai intranazāli ievadītas eksosomas, izolētas no zoba pulp…
An extended catalogue of ncRNAs in Streptomyces coelicolor reporting abundant tmRNA, RNase-P RNA and RNA fragments derived from pre-ribosomal RNA lea…
2022
Streptomyces coelicolor is a model organism for studying streptomycetes. This genus possesses relevant medical and economical roles, because it produces many biologically active metabolites of pharmaceutical interest, including the majority of commercialized antibiotics. In this bioinformatic study, the transcriptome of S. coelicolor has been analyzed to identify novel RNA species and quantify the expression of both annotated and novel transcripts in solid and liquid growth medium cultures at different times. The major characteristics disclosed in this study are: (i) the diffuse antisense transcription; (ii) the great abundance of transfer-messenger RNAs (tmRNA); (iii) the abundance of rnpB…
La eutrofización en los lagos someros mediterráneos: aplicabilidad de la DMA y un caso de estudio experimental en mesocosmos
2013
Este trabajo se centra en su mayor parte en el estudio de los efectos más directos de la eutrofización en los lagos someros mediterráneos y en el funcionamiento ecológico de este tipo de lagos cuando son sometidos a un incremento en la carga de nutrientes y a la presencia de peces. El trabajo también aborda el estudio de las metodologías más apropiadas para la evaluación de estos lagos mediante la aplicación de la Directiva Marco Europea del Agua (DMA). Este trabajo tiene dos secciones principales, siendo cada una parte de dos proyectos europeos que incluían lagos someros de distintas localidades europeas:(1) El proyecto SWALE que pretendía establecer las diferencias en el funcionamiento ec…
Human Topoisomerase I interaction with DNA on flexible nylon substrate for malaria diagnosis
The study of interaction between human Topoisomerase I (hTopo I) and the appropriate sequences of DNA is shown, with the aim to realize a biosensor for malaria diagnosis. Topoisomerases alter the topological state of DNA by catalysing the breaking and rejoining of DNA strands1. The ligase activity is fundamental for our biosensing strategy, revealing the pathology. hTopo I was chosen as a model system for the Plasmodium analogous. The biosensor is a new flexible and easy to degrade biochip printed on nylon by dip-pen lithography (DPL). It is realized exploiting the high specificity of complementary ssDNA2 and hTopo I ligase activity. DPL operation needs ultra-low amounts of DNA (0.5 µL) to …
New topoisomerase I inhibitors with condensed-azaindole structure
2012
A survey on algebraic dilatations
2023
In this text, we wish to provide the reader with a short guide to recent works on the theory of dilatations in Commutative Algebra and Algebraic Geometry. These works fall naturally into two categories: one emphasises foundational and theoretical aspects and the other applications to existing theories.
Honey Bee Pollen in Meagre (Argyrosomus regius) Juvenile Diets: Effects on Growth, Diet Digestibility, Intestinal Traits, and Biochemical Markers Rel…
2020
This research aimed to evaluate the effects of the inclusion of honey bee pollen (HBP) in meagre (Argyrosoumus regius) juveniles&rsquo
Extracellular Vesicle microRNAs Contribute to the Osteogenic Inhibition of Mesenchymal Stem Cells in Multiple Myeloma
2020
Osteolytic bone disease is the major complication associated with the progression of multiple myeloma (MM). Recently, extracellular vesicles (EVs) have emerged as mediators of MM-associated bone disease by inhibiting the osteogenic differentiation of human mesenchymal stem cells (hMSCs). Here, we investigated a correlation between the EV-mediated osteogenic inhibition and MM vesicle content, focusing on miRNAs. By the use of a MicroRNA Card, we identified a pool of miRNAs, highly expressed in EVs, from MM cell line (MM1.S EVs), expression of which was confirmed in EVs from bone marrow (BM) plasma of patients affected by smoldering myeloma (SMM) and MM. Notably,we found that miR-129-5p, whic…
The LuxR Regulators PcoR and RfiA Co-regulate Antimicrobial Peptide and Alginate Production in
2017
Cyclic lipopeptides (CLPs) are considered as some of the most important secondary metabolites in different plant-associated bacteria, thanks to their antimicrobial, cytotoxic, and surfactant properties. In this study, our aim was to investigate the role of the Quorum Sensing (QS) system, PcoI/PcoR, and the LuxR-type transcriptional regulator RfiA in CLP production in the phytopatogenic bacterium, Pseudomonas corrugata based on our previous work where we reported that the pcoR and rfiA mutants were devoid of the CLPs cormycin and corpeptin production. Due to the close genetic link between the QS system and the RfiA (rfiA is co-transcribed with pcoI), it was difficult to ascertain the specifi…
Rapport final du projet « Villes en Transition : le cas du quartier de de la Fontaine d’Ouche à Dijon"
2014
Comment mobiliser les citoyens autours de conduites éco-responsables en matière de consommation ? Nous avons souhaité, au travers de l’appel à projet MOVIDA, identifier les leviers d’une consommation plus durable en les situant dans une dynamique territoriale observée à l’échelle d’un ou plusieurs petits territoires, qui seront autant de terrains d’expérimentation. Cette démarche, qui articule plusieurs approches disciplinaires, entend éclairer les dimensions psycho-sociologiques et communicationnels de la consommation sans négliger les aspects géographiques et économiques.Notre hypothèse est la suivante : Les habitants des quartiers urbains dits sensibles manifestent des formes particulièr…