Search results for "SOSA"
showing 10 items of 74 documents
Synthesis of C3/C1-Substituted Tetrahydroisoquinolines
2015
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada scoparia leaves against a panel of human and parasitic proteases revealed an interesting activity profile of 2 towards human 20S proteasome. This outcome suggests that the 1,2,3,4-tetrahydroisoquinoline skeleton may be exploited as a template for the development of novel anticancer agents. In this article, we report the synthesis and chemical characterization of a new series of isosalsoline-type alkaloids (10-11) with variations at N2 and C3 positions with respect to the natural Compound 2, obtained by a synthetic strategy that involves the Bischler-Napieralski cyclization. The substrate for…
La Sicilia del gesso. Stratificazioni, tecniche costruttive e cultura
2020
Il volume contiene le relazioni del Convegno interdisciplinare dal titolo omonimo, svoltosi a Caltanissetta nel gennaio 2019, il primo dedicato integralmente agli aspetti geologici, archeologici, agli usi funzionali e artistici, agli aspetti etnoantropologici della civiltà del gesso. Mentre lo zolfo ha vissuto stagioni di interesse scientifico, economico, tecnologico, sindacale, antropologico e letterario, non è accaduto altrettanto al più dimesso gesso che pur costella il paesaggio rurale e urbano, in particolare della Sicilia centrale. Dai muretti in pietra di gesso, oggi preservati dall’Unesco, agli oratori di Giacomo Serpotta, il bianco abbacinante di questi diversi manufatti è frutto n…
Metallimalmikaivosten vesistövaikutukset : esimerkkinä Talvivaaran kaivoksen sulfaatti-, natrium- ja mangaanipäästöt
2013
Mining industry is expanding in Finland and it is expected to become a forerunner in taking environmental issues into account in its processes. Mines often lower the water quality of their surrounding waters and this may lead to salinization and eutrophication for instance. Salinization may be due to dissolved ions in the wastewater, like sulphate and sodium, and may cause the artificial stratification of a lake. Sulphate can also prevent the natural circulation of iron in the sediments, which favors the release of phosphorus and could lead to eutrophication. All impacts cannot be assessed in advance and not enough studies have been made concerning these substances. The Talvivaara mine in S…
Kohti parempaa terveysosaamista : lukion valinnaisen liikuntakurssin suunnittelu, toteutus ja arviointi
2012
Ontologie pour l'intégration de données d'observation de la Terre et contextuelles basée sur les relations topologiques
2018
National audience; Nous proposons une ontologie pour l'intégration de données d'observation de la Terre et de donnés contextuelles, à l'aide de relations topologiques spatiales et temporelles. Cette ontologie spécialise des standards, notamment SOSA, GeoSPARQL et OWL-Time. La base de connaissance décrite par cette ontologie est alimentée grâce à un processus qui sélectionne, transforme et intègre de données géospatiales hétérogènes (méta-données d'image satellite, données météorologiques, unités administratives, couverture terrestre, etc.). Ce processus s'appuie sur le tuilage des images pour traiter les données ayant une composante spatiale fixe, alors que les relations temporelles sont ca…
Does health literacy explain regional health disparities among adolescents in Finland?
2021
Health literacy (HL)—as a broad range of health-related competencies—has been proposed to be a promising construct in understanding health disparities better, also among adolescents. Several factors have been found to explain differences in adolescents’ HL levels; however, not much is known about how different regions of a country or majority/minority status is associated with HL, or whether HL is associated with regional health disparities. The aim of this study was to examine and compare HL and health levels among majority- and minority-language-speaking adolescents living in different regions of Finland, and to explore if HL explains regional health disparities, taking into account other…
Perustaitojen tukeminen ammatillisessa koulutuksessa
2019
Ammatillisessa koulutuksessa opiskelevien perustaitojen kirjo on hyvin laaja. On heitä, jotka pärjäävät ja omaksuvat helposti muuttuvassa yhteiskunnassa tarvittavia taitoja, mutta toisaalta on myös heitä, joiden taidot tarvitsevat tukea ja harjaannuttamista. TAHTI-hankkeessa tuetaan aikuisia tutkinnon suorittajia perustaitojen kehittymisessä. nonPeerReviewed
Novel concepts on the recovery of by-products from alkaline pulping
2016
Innovative biorefinery concepts were developed for the separation and utilization of organic materials, especially aliphatic carboxylic acids, lignin, and extractives, which are formed as by-products during wood-based alkaline delignification processes. The partial recovery of sodium as NaOH and aliphatic carboxylic acids from hardwood soda-AQ black liquor was studied via electrodialysis. The lignin was partly (about 59 % of the initial lignin) precipitated from black liquor by carbonation (pH to about 8.5) followed by electrodialysis or H2SO4 (pH to about 2), with subsequent precipitation of more lignin and the liberation of aliphatic acids. The Na2SO4 formed was successfully separated fro…
Significance of Induction Phenomena
1978
A number of foreign compounds induce the proliferation of the hepatic smooth endoplasmatic reticulum and thereby increase the activity of monooxygenases that metabolize drugs and other foreign compound. With reference to the safety of food additives some antioxidants have been examined by various authors for their inducing capacity, in doses well above those ingested with treated food and above the stipulated accepted daily intake (ADI). Thus feeding of rats with the very high dose of 500 mg/kg body weight of butylated hydroxtoluene (BHT) resulted in an increase in its own oxidative metabolism. Also in monkeys BHT produces an inductive increase of microsomal enzyme activity, cytochrome P 45…
Teoriaa ja käytäntöä vuorovaikutusosaamisen opettamisen tueksi
2022
Kirja-arvio teoksesta: Suvi-Tuuli Murumäki & Heljä Haapamäki-Niemi (toim.) 2022. Yhdessä – Näkökulmia vuorovaikutuksen oppimiseen ja opettamiseen. Äidinkielen opettajain liiton vuosikirja 2022.