Search results for "SOX"

showing 10 items of 240 documents

Evaluation of a Cell-Free Collagen Type I-Based Scaffold for Articular Cartilage Regeneration in an Orthotopic Rat Model.

2020

The management of chondral defects represents a big challenge because of the limited self-healing capacity of cartilage. Many approaches in this field obtained partial satisfactory results. Cartilage tissue engineering, combining innovative scaffolds and stem cells from different sources, emerges as a promising strategy for cartilage regeneration. The aim of this study was to evaluate the capability of a cell-free collagen I-based scaffold to promote cartilaginous repair after orthotopic implantation in vivo. Articular cartilage lesions (ACL) were created at the femoropatellar groove in rat knees and cell free collagen I-based scaffolds (S) were then implanted into right knee defect for the…

Settore BIO/17 - IstologiaPathologymedicine.medical_specialtyScaffoldcartilage tissue engineeringcollagen I-based scaffold02 engineering and technologySOX9lcsh:TechnologyArticle03 medical and health sciencesIn vivoarticular cartilage lesionmedicineGeneral Materials Sciencelcsh:Microscopycartilage regenerationAggrecan03 Chemical Sciences 09 Engineering030304 developmental biologylcsh:QC120-168.850303 health scienceslcsh:QH201-278.5Chemistrylcsh:TCartilageRegeneration (biology)021001 nanoscience & nanotechnologymusculoskeletal systemmedicine.anatomical_structurelcsh:TA1-2040ImmunohistochemistryArticular cartilage lesion; Cartilage regeneration; Cartilage tissue engineering; Collagen i-based scaffold; Orthotopic implantationlcsh:Descriptive and experimental mechanicslcsh:Electrical engineering. Electronics. Nuclear engineeringStem cellorthotopic implantation0210 nano-technologylcsh:Engineering (General). Civil engineering (General)lcsh:TK1-9971
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Electronic ionization mass spectra of 3-(5'-(3'-methylisoxazol))- and 3-(3'-(5'-methylisoxazol)-2-styryl-4(3H)quinazolinones of pharmaceutical intere…

2008

Settore CHIM/08 - Chimica Farmaceuticaisomeric styrylisoxazolylquinazolinones/Electronic ionization mass spectra
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The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα+ breast cancer cells

2013

In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breast cancer cells. The transition from an epithelial- to a mesenchymal-like phenotype was characterized by reduced expression of ERα, HER-2/Neu overexpression and loss of CD24 surface receptor (CD24(-/low)). Importantly, expression of key epithelial-to-mesenchymal transition (EMT) markers and upregulation of the stemness gene SOX2 was linked to acquisition of stem cell-like properties such as the ab…

Smad5 ProteinCancer ResearchEpithelial-Mesenchymal TransitionMAP Kinase Signaling SystemReceptor ErbB-2Active Transport Cell NucleusEstrogen receptorMice NudeBreast NeoplasmsBiologyArticleMicebreast cancerSOX2Cell MovementCell Line TumorGeneticsAnimalsHumansEpithelial–mesenchymal transitionKinase activityNeoplasm MetastasisPhosphorylationRNA Small InterferingMolecular BiologyAurora Kinase Ametastases mitosisSOXB1 Transcription FactorsEstrogen Receptor alphaCD24 AntigenXenograft Model Antitumor AssaysstemneGene Expression Regulation NeoplasticProto-Oncogene Proteins c-rafSettore BIO/18 - GeneticaTumor progressionembryonic structuresCancer researchMCF-7 CellsNeoplastic Stem CellsProto-Oncogene Proteins c-rafFemaleRNA InterferenceSignal transductionEstrogen receptor alphaNeoplasm Transplantation
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ChemInform Abstract: Synthesis of 4(5)-Phenacyl-imidazoles from Isoxazole Side-Chain Rearrangements.

2011

The reaction must be carried out under nitrogen atmosphere in deoxygenated solvent to prevent the oxidation of the imidazole products.

Solventchemistry.chemical_compoundchemistryPolymer chemistrySide chainImidazoleNitrogen atmosphereGeneral MedicineIsoxazolePhenacylChemInform
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CCDC 160804: Experimental Crystal Structure Determination

2001

Related Article: E.Aiello, S.Aiello, F.Mingoia, A.Bacchi, G.Pelizzi, C.Musiu, M.G.Setzu, A.Pani, P.La Colla, M.E.Marongiu|2000|Bioorg.Med.Chem.|8|2719|doi:10.1016/S0968-0896(00)00211-X

Space GroupCrystallography3-(3-Methyl-4-nitroso-1-propyl-1H-5-pyrazolyl)-5-methylisoxazoleCrystal SystemCrystal StructureCell ParametersExperimental 3D Coordinates
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CCDC 2053832: Experimental Crystal Structure Determination

2021

Related Article: Jevgeņija Lugiņina, Martin Linden, Māris Bazulis, Viktors Kumpiņš, Anatoly Mishnev, Sergey A. Popov, Tatiana S. Golubeva, Siegfried R. Waldvogel, Elvira E. Shults, Māris Turks|2021|Eur.J.Org.Chem.|2021|2557|doi:10.1002/ejoc.202100293

Space GroupCrystallographyCrystal SystemCrystal Structure3-{(17S)-[3beta-acetyloxy-28-norlupan-20(29)-en]-17-yl}-(isoxazol-5-yl)carboxylic acidCell ParametersExperimental 3D Coordinates
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CCDC 677637: Experimental Crystal Structure Determination

2008

Related Article: S.Margutti, D.Schollmeyer, S.Laufer|2008|Acta Crystallogr.,Sect.E:Struct.Rep.Online|64|o504|doi:10.1107/S1600536807066500

Space GroupCrystallographyCrystal SystemCrystal Structure4-(4-Fluorophenyl)-2-methyl-3-(1-oxy-4-pyridyl)isoxazol-5(2H)-oneCell ParametersExperimental 3D Coordinates
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CCDC 1917652: Experimental Crystal Structure Determination

2019

Related Article: E.S. Sales, A.J. Bortoluzzi, A.A. Merlo|2019|Acta Crystallogr.,Sect.E:Cryst.Commun.|75|896|doi:10.1107/S2056989019007412

Space GroupCrystallographyCrystal SystemCrystal Structure5-[4-(t-butoxy)phenyl]-3-[4-(n-octyloxy)phenyl]-45-dihydroisoxazoleCell ParametersExperimental 3D Coordinates
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CCDC 148166: Experimental Crystal Structure Determination

2001

Related Article: M.Carda, R.Portoles, J.Murga, S.Uriel, J.A.Marco, L.R.Domingo, R.J.Zaragoza, H.Roper|2000|J.Org.Chem.|65|7000|doi:10.1021/jo0009651

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(2R3aR)-3a-((4R)-22-Dimethyl-13-dioxolan-4-yl)-66-dimethylperhydro(13)oxazolo(34-b)isoxazole-2-carbonitrileExperimental 3D Coordinates
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CCDC 148165: Experimental Crystal Structure Determination

2001

Related Article: M.Carda, R.Portoles, J.Murga, S.Uriel, J.A.Marco, L.R.Domingo, R.J.Zaragoza, H.Roper|2000|J.Org.Chem.|65|7000|doi:10.1021/jo0009651

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters(2S3aS)-3a-((4R)-22-Dimethyl-13-dioxolan-4-yl)-66-dimethylperhydro(13)oxazolo(34-b)isoxazole-2-carbonitrileExperimental 3D Coordinates
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