Search results for "SPIO"

Iron oxides nanoparticles and titanate nanotubes dedicated to multimodal imaging and anticancer therapy

2013

The new implementations of nanoparticles in the medical field are one of the essential factors of the medical progress expected at the beginning of this XXIst century. Thus, the domain of the medical imaging is also affected by this technological evolution. This work consisted in developing theranostic probes with iron oxides nanoparticles (SPIO) and titanate nanotubes (TiONts) for multimodal imaging (magnetic/nuclear or magnetic/optical) and also possessing a therapeutic effect (hyperthermia/PDT or radiosensitization/PDT).The titanate nanotubes of this study have an average length of about 150 nm and were obtained by Kasuga's hydrothermal synthesis. These nanotubes present an outside diame…

Folate targeted coated SPIONs as efficient tool for MRI

2017

The development of more sensitive diagnostic tools allowing an early-stage and highly efficient medical imaging of tumors remains a challenge. Magnetic nanoparticles seem to be the contrast agents with the highest potential, if properly constructed. Therefore, in this study, hybrid magnetic nanoarchitectures were developed using a new amphiphilic inulin-based graft copolymer (INU-LAPEG-FA) as coating material for 10-nm spinel iron oxide (magnetite, Fe3O4) superparamagnetic nanoparticles (SPION). Folic acid (FA) covalently linked to the coating copolymer in order to be exposed onto the nanoparticle surface was chosen as the targeting agent because folate receptors are upregulated in many can…

Market must be defended: The role of counter-espionage policy in protecting domestic market welfare

2022

Governments of advanced economies are extremely concerned about the illicit acquisition of information on critical technologies employed by their industries, and countering this economic espionage is quickly becoming one of their top priorities. The present paper advances the theoretical analysis of the interaction between economic espionage and counter-espionage, and presents a first approximation to an inquiry into the rationale for the influence of market competition in its dynamics. The proposed model assumes a country with a one-market economy open to international trade whose product is supplied by domestic firms. Moreover, successful economic espionage implying market entry of foreig…

Combining inulin multifunctional polycation and magnetic nanoparticles: Redox-responsive siRNA-loaded systems for magnetofection

2019

Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are recognized as one of the most promising agents for theranostic applications. Among methods designed for siRNA delivery, magnetofection, that is, nucleic acid cell uptake under the influence of a magnetic field acting on magnetic nucleic acid vectors, is emerging as a unique approach to combining advantages such as strong improvement of the kinetics of the delivery process and the possibility of localizing nucleic acid delivery to an area where the magnetic field is applied. This paper reports on the preparation of siRNA loaded magnetoplexes&mdash

The effect of variation in developmental mode on the population dynamics of a spionid polychaete (Pygospio elegans) in a heterogeneous environment

2018

"Quand nous serons à mille, nous ferons une croix". Le contre-espionnage, un nouveau terrain de coopération entre gendarmes et policiers à la fin du …

2013

International audience; Si le travail respectif comme la collaboration des policiers et des gendarmes en matière de policejudiciaire et de maintien de l’ordre sont désormais mieux connus, leur coopération dans le contre-espionnagedemeure encore largement ignorée. En dépit de représentations mutuelles antagonistes, lalutte contre les menées étrangères montre l’entente entre les forces de l’ordre et révèle l’émergenced’un système national de sécurité intérieure, en partie structuré par cette défiance commune. Letravail des forces de l’ordre met également en lumière la xénophobie traversant alors une sociétéfrançaise voyant en chaque étranger, notamment d’Outre-Rhin, un espion possible.

Inulin-Ethylenediamine Coated SPIONs Magnetoplexes: A Promising Tool for Improving siRNA Delivery.

2015

An inulin based polycation (Inu-EDA) has been synthesized by the grafting of ethylenediamine molecules onto inulin backbone. The obtained inulin copolymer has been though to coat SPIONs (IC-SPIONs) and obtain stable magnetoplexes by complexation of IC-SPIONs with a model duplexed siRNA, for improving oligonucleotide transfection efficiency.The physical-chemical characteristics of IC-SPIONs and IC-SPIONs/siRNA magnetoplexes have been investigated by scanning and transmission electron microscopies, dynamic light scattering, FT-IR and qualitative surface elementary analysis. Cell compatibility and internalization in vitro of IC-SPIONs have been evaluated by MTS and fluorescence microscopy resp…

Variation in developmental mode and its effects on divergence and maintenance of populations

2012

Synthesis and study of new fluorescent probes for optical imaging, Cherenkov imaging and multimodal imaging

2015

The goal of this work was to prepare and study new fluorescent probes, which could give rise to novel optical or Cherenkov imaging agents. The first section of this work describes the synthesis of fluorescent subphthalocyanines and phthalocyanines probes, which possess relevant chemicals groups suitable for optical imaging applications. The optical and physico-chemical properties of the new probes were carefully examined to ensure they comply with the specification of the fluorophores for the desired application. The second part focused on the subsequent development of a few selected probes into real imaging agents. The biovectorisation of subphtalocyanines was achieved upon conjugation of …

Finnish Cyber Security Strategy and Implementation

2015

Technical and automated solutions and information networks, which make planning, guidance and implementation possible fast and in a cost-efficient way, are widely used in Finnish information society. The flipside of this development is increased dependency on extensive and complicated technical systems and information networks. Failures in these systems or, for example, in their power supply may rapidly affect comprehensive security in society. Threats against security in society have become more multifaceted and, as a consequence, more complicated. Threats can no longer be divided clearly into military and non-military threats or internal and external threats; they are often interconnected…