Search results for "STAGE"

Retrospektīvs pētījums par dzīvildzi resnās zarnas vēža II stadijā, atkarībā no ārstēšanas stratēģijas

2017

Ievads: Adjuvanta ķīmijterapija pacientiem ar diagnosticētu II (UICC) stadijas resnās zarnas vēzi ir apsverama. Pacientu dalījums augsta un zema riska grupās, palīdz izlemt, vai pēc ķirurģiskas ārstēšanas ir indicēta ķīmijterapija, lai gan dzīvildzes ieguvumi nav ne plaši pētīti, nedz arī pierādīti. Tāpēc, autora mērķis šajā pētījumā bija salīdzināt piecu gadu dzīvildzi UICC II stadijas resnās zarnas vēža pacientiem, kuri saņēma adjuvantu ķīmijterapiju, un pacientiem, kuri ķīmijterapiju nesaņēma. Metodes: Dati par pacientiem ar II stadijas resnās zarnas vēzi, tika iegūti Paula Stradiņa Klīniskās universitātes slimnīcā Rīgā, Latvijā, Onkoloģijas klīnikā. Diagnozes apstiprināšanas laiks no 20…

Identity Development in Adulthood: Introduction

2016

In line with Erikson’s suggestions, increasing empirical evidence substantiates that considerable identity development takes place over the course of adulthood. What then does identity development during adulthood entail? The key findings of adult identity formation from four culturally different countries, and the challenges of analyzing the complex concept of identity are discussed. Although a wide array of identity measures are available, they have not been sufficiently validated for use with middle-aged or older adults. Additionally, different measures may yield results that are not comparable across studies. More studies are needed on adult identity development in populations represent…

"Sądowa egzekucja" kontaktów z dzieckiem

2019

Intraspecific variation in mating behaviour does not cause sexual isolation between Drosophila virilis strains

2005

There is increasing evidence that mate recognition systems vary within species. We studied the courtship rituals of five Drosophila virilis strains to investigate this intraspecific variation. Males that actively and persistently courted the female without paying much attention to the female's behaviour were the most successful at copulating. Intraspecific variation in mating rituals was high, but not as high as at the species level and it was not high enough to cause sexual isolation between the strains. The differences in courtship interactions of the strains reflected their geographical origin. Males from one of the strains did not produce audible song during their courtship, but still m…

Spatially restricted expression of PlOtp, a Paracentrotus lividus Orthopedia-related homeobox gene, is correlated with oral ectodermal patterning and…

1999

ABSTRACT Several homeobox genes are expressed in the sea urchin embryo but their roles in development have yet to be elucidated. Of particular interest are homologues of homeobox genes that in mouse and Drosophila are involved in patterning the developing central nervous system (CNS). Here, we report the cloning of an orthopedia (Otp)-related gene from Paracentrotus lividus, PlOtp. Otp is a single copy zygotic gene that presents a unique and highly restricted expression pattern. Transcripts were first detected at the mid-gastrula stage in two pairs of oral ectoderm cells located in a ventrolateral position, overlying primary mesenchyme cell (PMC) clusters. Increases in both transcript abund…

Advancing the ecotoxicological relevancy of zebrafish : application of early-juvenile 20dpfZF to assess xenoestrogenicity of environmental chemicals …

2014

Presence of Naraoia Walcott, 1912 (Nektaspida, Arthropoda) in the middle Cambrian of Europe (Murero, NE Spain).

2018

The genus Naraoia Walcott, 1912, a Burgess Shale-type fossil known from the lower and middle Cambrian of British Columbia (Canada), Idaho and Utah (USA), as well as from Yunnan and Guizhou provinces (China), is now reported from the middle Cambrian of Murero (Zaragoza, Spain), which is the first record in the Acadobaltic province. The only fragmented specimen found is determined as Naraoia sp., its age being Pardailhania multispinosa Zone (Drumian Stage). This new datum reinforces the hypothesis of the existence of a cosmopolitan faunal substrate in early Cambrian times, which is to some extent refl ected in the mid Cambrian by faunal groups of low evolutionary potential as the family Narao…

Instrumental and sensory evaluation of eating quality of peaches and nectarines

2012

The influence of flesh firmness on consumer acceptance and its relationship with total soluble solids (TSS), titratable acidity (TTA) and sensory analysis were studied for fruits of ‘September Sun’ and ‘Sweet September’ (low acid) peach (Prunus persica (L.) Batsch), and ‘Maria Dolce’ (low acid) and ‘Venus’ nectarine (Prunus persica (L.) Batsch, var. nucipersica) cultivars. Sensory descriptors, assessed by a short-trained panel, were firmness, sweetness, sourness, aroma, acceptability. Different stages of fruit firmness did not always result in significant differences of TSS, TTA and their ratio, but the panel was able to discriminate fruit ripening stages, in terms of fruit firmness, aroma …

Use of Early Juvenile Zebrafish Danio Rerio for In-Vivo Assessment of Endocrine Modulation by Xenoestrogens

2013

Reliable and cost-effective early-life stage (ELS) bioassays incorporating practical experimentation without compromising scientific relevance are crucial in chemical risk assessment. This study investigated the use of 20 days- post-fertilization life stage ( 20dpfZF ) of zebrafish Danio rerio to screen environmental chemicals known to be estrogenic in adult fish. Firstly, studies with key genes in steroidogenesis were conducted; the brain isoform of aromatase gene ( cyp19a1b ) being the most prominently expressed biomarker. Regulation of mRNA levels of molecular biomarkers, vitellogenin 1 gene ( vtg1) and cyp19a1b were selected to assess the endocrine modulation by xenoestrogens, 17α-ethin…

Detection of

2019

Circulating tumor DNA (ctDNA) has emerged as a non-invasive “liquid biopsy” for early breast cancer diagnosis. We evaluated the suitability of ctDNA analysis in the diagnosis of early breast cancer after mammography findings, comparing PIK3CA and TP53 mutations between tumor biopsies and pre-biopsy circulating DNA. Matched plasma and frozen fresh tissue biopsies from patients with Breast Imaging-Reporting and Data System (BIRADS) 4c/5 mammography findings and subsequent diagnosis of primary breast cancer were analyzed using NGS TruSeq Custom Amplicon Low Input Panel (Illumina) and plasma SafeSEQ (Sysmex Inostics). The same plasma and tumor mutations were observed in eight of 29 patients (27…