Search results for "STELLA"
showing 10 items of 1995 documents
Amphiregulin activates human hepatic stellate cells and is upregulated in non alcoholic steatohepatitis
2015
AbstractAmphiregulin (AR) involvement in liver fibrogenesis and hepatic stellate cells (HSC) regulation is under study. Non-alcoholic fatty liver disease (NAFLD) and its more severe form non-alcoholic steatohepatitis (NASH) may progress to cirrhosis and hepatocellular cancer (HCC). Our aim was to investigate ex vivo the effect of AR on human primary HSC (hHSC) and verify in vivo the relevance of AR in NAFLD fibrogenesis. hHSC isolated from healthy liver segments were analyzed for expression of AR and its activator, TNF-α converting enzyme (TACE). AR induction of hHSC proliferation and matrix production was estimated in the presence of antagonists. AR involvement in fibrogenesis was also ass…
RELEASE OF CATECHOLAMINES FROM THE HEART
1966
Publisher Summary This chapter discusses the release of catecholamines from the heart. The isolated heart of the rabbit with the sympathetic nervous supply from the right stellate ganglion intact was set up according to Hukovio and Muscholl. The ganglion was stimulated for 30 s at supramaximal voltage with rectangular impulses of 3–5 ms duration a frequency of 10 shocks/s. Each stimulation period was followed by a resting period of 30 s. In the rabbit, four doses of 50 mg/kg l-α-methyldopa decreased the noradrenaline concentration in auricles, right, and left ventricles by 38–60%. An equimolar amount of α-methyl noradrenaline was detected in the tissues. Reserpine and guanethidine in doses,…
Beta-2-glycoprotein I is growth regulated and plays a role as survival factor for hepatocytes
2004
Beta-2-glycoprotein I (beta(2)GPI) is mainly produced by the liver and is found in plasma partially associated to lipoproteins. Although various properties have been attributed to this protein, its physiological role remains still unclear. We investigated its expression in cultured liver cells and in regenerating liver. Expression studies in HepG2 cells demonstrate that beta(2)GPI mRNA is regulated in a cell cycle-dependent manner, with very low expression in low cycling conditions and increasing levels in proliferating cells. p21 WAF-dependent growth arrest, induced by butyrate treatment, down-regulate beta(2)GPI mRNA levels. Immunolocalization in normal rat liver shows a non-homogeneous p…
Biogēno procesu modelēšanas iespēju novērtējums pāraugušās audzēs
2019
Maģistra darbā izstrādāts biogēno procesu norises modelis neskartās, pāraugušās priežu audzēs, kuru iespējams izmantot procesu paredzēšanai nākotnē. Izstrādātais modelis pilnveido zināšanas par mežaudzē notiekošajiem procesiem un atsevišķiem ietekmējošiem faktoriem. Simulācijās izmantoti tādi biogēniskie faktori kā temperatūras, nokrišņu, vēja ātruma un kukaiņu nodarītā kaitējuma izvērtējums. Simulāciju scenāriji izstrādāti pāraugušām priežu audzēm Latvijas teritorijā, kuri izvietoti katrs savā reģionā (kopā 4 pētījumu pilotteritorijas) un atrodas ne tālāk par 50 km no meteoroloģisko novērojumu stacijas. Iegūtie rezultāti liecina, ka pētāmajās mežaudzēs būtiskākais ir tās vecums, bet apskat…
CNO and pep solar neutrino measurements and perspectives in Borexino
2015
International audience; The detection of neutrinos emitted in the CNO reactions in the Sun is one of the ambitious goals of Borexino Phase-II. A measurement of CNO neutrinos would be a milestone in astrophysics, and would allow to solve serious issues in current solar models. A precise measurement of the rate of neutrinos from the pep reaction would allow to investigate neutrino oscillations in the MSW transition region. The pep and CNO solar neutrino physics, the measurement in Borexino Phase-I and the perspectives for the new phase are reviewed in this proceeding.
Measurement of Solar pp-neutrino flux with Borexino: results and implications
2015
International audience; Measurement of the Solar pp-neutrino flux completed the measurement of Solar neutrino fluxes from the pp-chain of reactions in Borexino experiment. The result is in agreement with the prediction of the Standard Solar Model and the MSW/LMA oscillation scenario. A comparison of the total neutrino flux from the Sun with Solar luminosity in photons provides a test of the stability of the Sun on the 10(5) years time scale, and sets a strong limit on the power production by the unknown energy sources in the Sun.
Improved measurement of $^8$B solar neutrinos with $1.5 kt·y$ of Borexino exposure
2017
We report on an improved measurement of the $^8$B solar neutrino interaction rate with the Borexino experiment at the Laboratori Nazionali del Gran Sasso. Neutrinos are detected via their elastic scattering on electrons in a large volume of liquid scintillator. The measured rate of scattered electrons above 3 MeV of energy is $0.223\substack{+0.015 \\ -0.016}\,(stat)\,\substack{+0.006 \\ -0.006}\,(syst)$ cpd/100 t, which corresponds to an observed solar neutrino flux assuming no neutrino flavor conversion of $\Phi\substack{\rm ES \\ ^8\rm B}=2.57\substack{+0.17 \\ -0.18}(stat)\substack{+0.07\\ -0.07}(syst)\times$10$^6$ cm$^{-2}\,$s$^{-1}$. This measurement exploits the active volume of the …
Variation in the Sizes of Chthamalid Barnacle Post-Settlement Cyprids on European Shores
2001
As part of a wider study on the settlement and recruitment of Chthamalus spp. in Europe, this study investigated whether chthamalid cyprids can be separated by length on a European scale. Variation in cyprid length with latitude and temporal variation at selected localities were also examined. The lengths of cyprids collected between 1996-1999 on nine rocky shores in Europe are reported. Elminius modestus cyprids were found only at Roscoff, NW France and could be distinguished due to their Carapace shape and length. They showed a unimodal length distribution, measuring between 450 and 625 mum, with no variation in length between the two sampling dates (1997 and 1998). Based on carapace shap…
Women Scientists Who Made Nuclear Astrophysics
2019
Female role models reduce the impact on women of stereotype threat, i.e. of being at risk of conforming to a negative stereotype about one’s social, gender, or racial group (Fine in Delusion of Gender. W.W. Norton & Co. NY, p. 36, 2010 [1]; Steele and Aronson in J Pers Soc Psychol 69:797–811, 1995 [2]). This can lead women scientists to underperform or to leave their scientific career because of negative stereotypes such as, not being as talented or as interested in science as men. Sadly, history rarely provides role models for women scientists; instead, it often renders these women invisible (CafeBabel Homepage [3]). In response to this situation, we present a selection of twelve outst…
Population Properties of Compact Objects from the Second LIGO-Virgo Gravitational-Wave Transient Catalog
2021
Abbott, R., et al. (LIGO and Virgo Collaboration)