6533b833fe1ef96bd129b5d2
RESEARCH PRODUCT
RELEASE OF CATECHOLAMINES FROM THE HEART
E. Muschollsubject
medicine.medical_specialtyMonoamine oxidaseChemistryStimulationIsolated heartLeft VentriclesReserpineGanglionEndocrinologymedicine.anatomical_structureStellate ganglionInternal medicinemedicineGuanethidinemedicine.drugdescription
Publisher Summary This chapter discusses the release of catecholamines from the heart. The isolated heart of the rabbit with the sympathetic nervous supply from the right stellate ganglion intact was set up according to Hukovio and Muscholl. The ganglion was stimulated for 30 s at supramaximal voltage with rectangular impulses of 3–5 ms duration a frequency of 10 shocks/s. Each stimulation period was followed by a resting period of 30 s. In the rabbit, four doses of 50 mg/kg l-α-methyldopa decreased the noradrenaline concentration in auricles, right, and left ventricles by 38–60%. An equimolar amount of α-methyl noradrenaline was detected in the tissues. Reserpine and guanethidine in doses, which lower but do not block completely the binding capacity of the amine stores, cause a greater loss of noradrenaline than of α-methyl noradrenaline. Balance experiments carried out on isolated rabbit hearts indicate that monoamine oxidase activity is responsible for the preferential loss of noradrenaline.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1966-01-01 |