Search results for "STING"
showing 10 items of 3756 documents
In response: Genomic profile of breast cancer.
2015
Response to: Plun-Favreau J, Svedman C, Valentine W, Rouzier R. Genomic profile of breast cancer. Expert Rev Pharmacoecon Outcomes Res 2015;15(3):393–94We would like to express our gratitude for th...
The treatment of advanced gastric cancer: current strategies and future perspectives.
2008
<i>BRAF</i> Mutation Testing in Lynch Syndrome Diagnostics: Performance and Efficiency According to Patient's Age
2019
Background: BRAF V600E mutations are reportedly associated with sporadic microsatellite-unstable (MSI) colorectal cancer (CRC), while rarely detected in CRCs of Lynch syndrome (LS) patients. Therefore, current international diagnostic guidelines recommend somatic BRAF mutation testing in MLH1-deficient MSI CRC patients to exclude LS. As sporadic BRAF- mutant MSI CRC is a disease of the elderly, while LS-associated CRC usually occurs at younger age, we hypothesized that the efficacy of BRAF testing in LS diagnostics may be age-dependent. Methods: We systematically compared the prevalence of BRAF mutations in LS-associated CRCs and MSI CRCs from population-based cohorts in different age group…
Hereditary ovarian cancer.
2008
Apoptosis is a form of cell death that permits the removal of damaged, senescent or unwanted cells in multicellular organisms, without damage to the cellular microenvironment. Defective apoptosis represents a major causative factor in the development and progression of cancer. The majority of chemotherapeutic agents, as well as radiation, utilize the apoptotic pathway to induce cancer cell death. Resistance to standard chemotherapeutic strategies also seems to be due to alterations in the apoptotic pathway of cancer cells. Recent knowledge on apoptosis has provided the basis for novel targeted therapies that exploit apoptosis to treat cancer. These new target include those acting in the ext…
408 Phase I, first-in-human trial evaluating BI 1387446 (stimulator of interferon genes [STING] agonist) alone and combined with BI 754091 (anti-prog…
2020
Background Activation of the STING pathway in intratumoral immune cells leads to increased type I interferon production, promoting recruitment and priming of T-cells against tumor antigens, and providing anti-tumor activity.1 Intratumoral administration of STING agonists has resulted in notable therapeutic activity in animal models.1 STING agonists have also shown clinical activity in patients, which was more pronounced when combined with an anti-PD-1 antibody.2,3 BI 1387446 potently and highly selectively activates the STING pathway; BI 754091 is a humanized IgG4 anti-PD-1 monoclonal antibody. Intratumoral administration of BI 1387446 resulted in tumor regression, and enhanced the activity…
Effects of 8-OH-DPAT on open field performance of young and aged rats prenatally exposed to diazepam: a tool to rveal 5-HT1a receptor function
2003
Central GABAergic and serotoninergic systems interact with one another and are implicated in controlling different behaviours. A gentle early long-lasting handling can prevent the deficits in locomotion and exploration in open field (O.F.) in 3-month-old male rats prenatally exposed to diazepam (DZ). Purpose of this study was to extend the research to older handled rats prenatally exposed to DZ and to assess the activity of 5-HT1A receptors (Rs), evaluating the performance in O.F. at 3 and 18 months of age following 8-OH-DPAT administration. A single daily s.c. injection of DZ (1.5 mg/kg) from gestation day 14 to gestation day 20 induced in aged, but not in young rats, a decrease in total d…
Developing and using tasks for the assessment of speaking
2019
This article provides an overview of the development and use of tasks for the assessment of speaking. It first addresses the key role of the assessment of the skill of speaking within language assessment in general and in the context of teaching and learning foreign languages. Then, it discusses how social changes and research have reshaped the way speaking is defined and operationalized, and focuses on how speaking can be assessed more validly and reliably today. The central role of tasks is also discussed, together with the importance of taking into consideration the implications and impact of different task characteristics. Some recommendations for the development of useful and meaningfu…
Soft proton exchanged channel waveguides in congruent lithium tantalate for frequency doubling
2010
We report on stable optical waveguides fabricated by soft-proton exchange in periodically-poled congruent lithium tantalate in the a-phase. The channel waveguides are characterized in the telecom wavelength range in terms of both linear properties and frequency doubling. The measurements yield a nonlinear coefficient of about 9.5pm/V, demonstrating that the nonlinear optical properties of lithium tantalate are left nearly unaltered by the process. (C) 2010 Optical Society of America
Optical Plasmonic Nano-Antennas Array for Energy Harvesting Applications
2019
Optical nanoantennas have been of great interest recently due to their ability to support a highly efficient, localized surface plasmon resonance and produce significantly enhanced and highly confined electromagnetic fields. The Yagi nanoantenna, an optical analog of the well-established radiofrequency Yagi antenna, stands out by its efficient unidirectional light emission and enhancement. In this paper, an investigation on a novel optical plasmonic nanoantennas array for energy harvesting application is proposed. The study of a novel Yagi nanorectennas array, by optimizing its geometrical parameters, is reported. All the simulations are carried out by using the CST Studio Suite 2018 softwa…
Measured and predicted light attenuation in dense coastal upslope fog at 650, 850, and <inline-formula><math display="inline" overflow="scro…
2008
Free-space optics FSO has gained considerable importance in this decade of demand for high-bandwidth transmission capabilities. FSO can provide the last mile solution, but the availability and reliability issues concerned with it have received increasing attention and need thorough investigation. In this work, we present our results on fog attenu- ation measurement and prediction at wavelengths 650, 850, and 950 nm with peak values up to 500 dB/km. For the attenuation measurement, optical wavelengths are transmitted over the same path of fog in free air to a receiver, measuring the power at every wavelength. The measure- ment of fog attenuation was performed at the France Telecom RD free-sp…