Search results for "STING"

Outcome of liver cancer patients with SARS‐CoV‐2 infection: an international, multicentre, cohort study

2022

Background & Aims Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with liver cancer is lacking. This study characterizes the outcomes and mortality risk in this population. Methods Multicentre retrospective, cross-sectional, international study of liver cancer patients with SARS-CoV-2 infection registered between February and December 2020. Clinical data at SARS-CoV-2 diagnosis and outcomes were registered. Results Two hundred fifty patients from 38 centres were included, 218 with hepatocellular carcinoma (HCC) and 32 with intrahepatic cholangiocarcinoma (iCCA). The median age was 66.5 and 64.5 years, and 84.9% and 21.9% had cirrhosis…

Porcine Model for Internal Mammary Vessels Harvesting

2018

Recipient vessels selection is crucial for successful microsurgical breast reconstruction. The internal mammary vessels (IMVs) have gained great popularity, and they are often selected as first choice recipient vessels. The IMVs can be exposed for microvascular anastomosis through a rib-removing (trans-costal) or a rib-sparing (intercostal) approach.1–3 Because the vessels are located between the rib cage and the parietal pleura, adequate training is needed to avoid and eventually manage bleedings and pleural perforation. This training is better performed in a nonhuman model. Our aim was to investigate the pig as a surgical model for IMVs harvesting to be used in training.

Testing for local structure in spatiotemporal point pattern data

2017

The detection of clustering structure in a point pattern is one of the main focuses of attention in spatiotemporal data mining. Indeed, statistical tools for clustering detection and identification of individual events belonging to clusters are welcome in epidemiology and seismology. Local second-order characteristics provide information on how an event relates to nearby events. In this work, we extend local indicators of spatial association (known as LISA functions) to the spatiotemporal context (which will be then called LISTA functions). These functions are then used to build local tests of clustering to analyse differences in local spatiotemporal structures. We present a simulation stud…

Seasonal Forecasting methods: an empirical analysis at sectoral and territorial levels.

2011

Suitability of two rapid lateral flow immunochromatographic assays for predicting SARS‐CoV‐2 neutralizing activity of sera

2020

Purpose: Assessment of commercial SARS-CoV-2 immunoassays for their capacity to provide reliable information on sera neutralizing activity is an emerging need. We evaluated the performance of two commercially-available lateral flow immunochromatographic assays (LFIC) (Wondfo SARS-CoV-2 Antibody test and the INNOVITA 2019-nCoV Ab test) in comparison with a SARS-CoV-2 neutralization pseudotyped assay for COVID-19 diagnosis in hospitalized patients, and investigate whether the intensity of the test band in LFIC associates with neutralizing antibody (NtAb) titers. Patients and Methods: Ninety sera were included from 51 patients with moderate to severe COVID-19. A green fluorescent protein (GFP)…

Application of DNA techniques for identification using human dental pulp as a source of DNA

1992

Dental pulp tissue could be obtained in most cases from materials obtained under experimental conditions and from forensic casework (air accidents, burned and putrefied bodies). Teeth extracted during dental treatment (n = 30) were stored for 6 weeks and 4 years at room temperature. In addition teeth (n = 10) extracted from jaw fragments that had been stored for 15 years at room temperature, and teeth extracted post mortem from actual identification cases (n = 8) were investigated. Following extraction from dental pulp tissue the DNA concentration was measured by fluorometry. The amount of DNA obtained from the dental pulp tissue of a single tooth varied from 6 micrograms to 50 micrograms D…

A stochastic dynamic model to evaluate the influence of economy and well-being on unemployment control

2018

[EN] This paper presents a stochastic dynamic mathematical model to study the evolution of the unemployment rate and other relevant related variables in a country. This model is composed by three basic interrelated subsystems: demographic, economic and wellbeing ones. A key aspect of this model is that it considers three UN well-being variables simultaneously: Human Development Index, Gender Empowerment Index and Gender Differentiation Index. These variables involve key concepts for human development, as Health, Education, Economy and Female Labor. With this model, the most outstanding variables found in the literature in relation with unemployment control can be used to design strategies a…

Experimental Studies Regarding the Mechanical Behaviour of Silicon-Coated and Uncoated P.A. 6.6 Fabrics

2014

These paper aims to present an experimental study for determining the mechanical properties of woven fabrics used for airbags manufacturing. In order to realise the study, there were chosen two types of fabric, one that is coated with silicon and one that is uncoated. The experimental tests that were carried out were uniaxial tension tests for samples extracted on the warp and on the weft direction, the Bias test, a test specific for shear loads and the dome test, a test specific for biaxial loads. For the uniaxial tension test the force-displacement curve was obtained and the maximum values of the loads and the displacement. For the last two tests (bias test and dome test) there have been …

An in vitro evaluation of the effect of sandblasting and laser surface treatment on the shear bond strength of a composite resin to the facial surfac…

2015

Objectives: The present study was conducted to evaluate the optimal method of enhancing the bond strength of a composite resin to the facial surface of the primary anterior stainless steel crowns using various surface treatments namely Nd: YAG laser surface treatment, sandblasting , alloy primer application and no surface treatment. Study Design: The study sample consisted of 60 primary anterior stainless steel crowns (UnitekTM size R 4), with 15 samples randomly divided into the 4 study groups, embedded in acrylic blocks. The facial surface of these surface treated crowns was utilized as the bonding surface to which 2.5mm diameter composite resin cylinders were bonded for the evaluation of…

Prehatching maternal investment and offspring immunity in the pied flycatcher (Ficedula hypoleuca).

2007

Maternal investment in offspring immunity via egg quality may be an adaptive evolutionary strategy shaped by natural selection. We investigated how maternal investment in eggs can influence offspring immunity by conducting two experiments. First, we manipulated foraging performance of the mothers before egg laying by attaching a small weight to their back feathers. During the nestling period, we investigated offspring total antibody production at the age of 7 days and after antibody challenge, and conducted a partial cross-fostering design to separate the effects of the experiment and rearing-related variation on offspring immunity. In a separate experiment, partial cross-fostering with ant…