Search results for "STING"

Skin Dendritic Cells in Murine Cutaneous Leishmaniasis

2002

Studies of the immunopathogenesis of Leishmania major-induced murine cutaneous leishmaniasis provide a framework for understanding the evolution of L. major infection of skin in humans and the foundation for rationale vaccine design. Experiments in which infection is initiated with "suprap hysiologic" numbers of parasites clearly identify Th-derived type I cytokines as essential participants in macrophage activation and macrophage nitric oxide production as prerequisite for parasite control. Dendritic cells, rather than macrophages, appear to be responsible for L. major-specific Th priming in these studies. Recent studies of murine cutaneous leishmaniasis in a model system in which infectio…

Evaluation of the force generated by gradual deflection of 0.016-inch NiTi and stainless steel orthodontic wires in self-ligating metallic and esthet…

2019

Background The purpose of this study was to evaluate the deflection forces of 0.016-inch Nitinol and stainless steel orthodontic wires, in association to different self-ligating brackets. Material and Methods Specimens were mounted in a clinical simulation model and evaluated in a Universal Testing Machine (INSTRON 3342), using a 10N load cell and ISO 15,841, as a protocol. Eight of these models were prepared, each one for the bonding of each set of self-ligating accessories to be tested: Damon Q, Damon Clear (Ormco), In-Ovation R, In-Ovation C (GAC), BioQuick, QuickClear (Forestadent), SmartClip and Clarity SL (3M). Data were subjected to One-way ANOVA, followed by Tukey tests (P<0.05). Re…

Sensitivity and negative predictive value of treadmill exercise stress testing for the diagnosis of catecholaminergic polymorphic ventricular tachyca…

2015

The "Neurocentric" Approach to Essential Hypertension: How Reliable is the Paradigm of Hyperkinetic Hypertension? A Focus on the Sympathetic Nervous …

2017

BACKGROUND: Clinic resting heart rate (RHR), is one of the cardiovascular parameters more easily measurable. In the general population RHR has been associated with total and cardiovascular mortality and higher rate of vascular events. OBJECTIVE: The case of essential hypertension is in some ways peculiar: in the past decades has often been attributed to hypertensive subjects higher values of RHR than healthy controls as a result of the effects of the different factors leading to the development of essential hypertension itself, first of all the presence of an increased tone of the sympathetic nervous system Methods: Several excellent articles debated the issue of autonomic dysfunction in es…

The influence of the tape-casting process parameters on the geometric characteristics of SiC tapes

1998

Abstract The production process of the tape-casting technique applied to the production of porous ceramic membranes, suitable for the separation of different chemical species, has been explored, with emphasis on the influence of the operative parameters on the macrogeometric characteristics of the manufactured ceramic porous tapes. The effects of the slurry casting rate, the doctor blade height and the mean particle diameter have been studied and the results reported. The characterization analyses indicate the degree of reliability of this technique to produce planar SiC components and the importance of the particle size in enhancing the structural homogeneity. A study on the variance analy…

Initial Preparation and Characterization of Single Step Fabricated Intermediate Temperature Solid Oxide Fuel Cells (IT-SOFC)

2013

In this study, facile tape casting process has been successfully carried out to fabricate an unit anode supported intermediate temperature solid oxide fuel cell (IT-SOFC) with four different layers: a composite cathode which is a mix of La0.6Sr0.4Co0.2Fe0.8O3 (LSCF48) and Gd0.1Ce0.9O1.9 (GDC10), GDC10 as thin electrolyte layer, NiO-GDC10 without pore former as thin anode functional layer (AFL), and anode support layer of NiO-GDC10 with carbon pore former. The multi-layer was sintered once to produce an unit planar cell. An OCV of 1.002 V at 500 °C, and maximum power density of 466 mW cm–2 at 648 °C are obtained. These results indicate negligible leakage of fuel through electrolyte. Furtherm…

Glycerol selective oxidation to lactic acid over AuPt nanoparticles; Enhancing reaction selectivity and understanding by support modification

2020

2 Schemes, 3 Tables, 5 Figures.

Perceived minerality in sauvignon blanc wine: chemical reality or cultural construct?

2016

International audience; The study aimed to determine the relationship between perceived mineral character in wine and wine chemical composition. We investigated the sensory properties and chemical composition of sauvignon blanc wines from two major sauvignon-producing countries, New Zealand and France. Sensory experiments employing 16 wines (8 French, 8 New Zealand) were conducted in Marlborough, New Zealand and in three regions of France, namely Bordeaux, Burgundy, and the Sancerre/Loire region. Wine professionals (31 New Zealanders and 32 French professionals) sensorially characterised the 16 wines under three conditions, bouquet only (ortho-nasal olfaction), palate only (nose clip condit…

Graphic model for evaluating the competitiveness and eco-efficiency of eco-innovative projects

2019

Eco-innovation describes the creation of novel and competitively priced goods, processes, systems, services, policies, and procedures that satisfy human needs and improve the quality of life while ensuring sustainable development with minimal use of natural resources and minimal release of toxic substances. This article delves into one of the most pressing problems in improving the assessment of eco-innovative projects meant to effect sustainable development. The article also proposes new criteria for evaluating eco-innovation projects. The purpose is to develop and propose a graphic model by which to assess the innovativeness, competitiveness, and eco-efficiency of eco-innovation projects.…

Electric Mobility in Portugal: Current Situation and Forecasts for Fuel Cell Vehicles

2021

In recent years, the growing concern for air quality has led to the development of sustainable vehicles to replace conventional internal combustion engine (ICE) vehicles. Currently, the most widespread technology in Europe and Portugal is that of Battery Electric Vehicles (BEV) or plug‐in HEV (PHEV) electric cars, but hydrogen‐based transport has also shown significant growth in the commercialization of Fuel Cell Electric Vehicles (FCEV) and in the development of new infrastructural schemes. In the current panorama of EV, particular attention should be paid to hydrogen technology, i.e., FCEVs, which is potentially a valid alternative to BEVs and can also be hybrid (FCHEV) and plug‐in hybrid…