Search results for "STING"
showing 10 items of 3756 documents
Vertex Distinguishing Edge- and Total-Colorings of Cartesian and other Product Graphs
2012
International audience; This paper studies edge- and total-colorings of graphs in which (all or only adjacent) vertices are distinguished by their sets of colors. We provide bounds for the minimum number of colors needed for such colorings for the Cartesian product of graphs along with exact results for generalized hypercubes. We also present general bounds for the direct, strong and lexicographic products.
Étude climatique de la mousson vietnamienne et applications à la prévision saisonnière
2008
This thesis aims at documenting the physical and dynamic processes associated with the monsoon circulation of Vietnamese regional and synoptic scales, to explore the predictability of its key components and develop statistical and dynamical methods for forecasting the monsoon onset and seasonal. It is divided into two parts. The first part is, in fact, a climate study based on analysis of diagnostic data: - first, the monthly rainfall and temperature data station over the period 1960-2000 are used to analyze the cycle and the variability of these fields on the seven traditional climatic regions of Vietnam using the observed precipitation in various stations. Classifications and correlations…
Structure-function relationships of brazzein, a sweet-tasting protein and its interactions with the human sweet taste receptor
2018
International audience; Brazzein is a small heat- and pH-stable sweet-tasting protein isolated from the West African plant, Pentadiplandra brazzeana. Brazzein combines a highly sweet potency, a long history of human consumption, and a remarkable stability, giving it great potential as a natural sweetener. Due to the difficulties of obtaining brazzein from its natural source, several efforts have been made to express brazzein using various heterologous expression systems. Brazzein like all classes of sweet compounds (natural sugars, natural and artificial sweeteners) are perceived through the activation of the T1R2/T1R3 heterodimeric sweet taste receptor. T1R2 and T1R3 subunits are members o…
Minéralité du Chasselas: une notion sensorielle partagée par les professionnels?
2015
Le projet «Minéralité des vins : étude et valorisation d’un concept en vogue mais méconnu» a été sélectionné dans le cadre du programme de coopération territoriale européenne Interreg IV A France-Suisse 2007–2013.; Les commentaires de dégustation utilisent de plus en plus la notion de minéralité pour décrire les vins. Toutefois, la définitionde ce facteur n’est pas fixée et s’appuie souvent sur des descripteurs sensoriels divers. Cet article vise à savoir si, au-delà de la définition, les professionnels arrivent à accorder leur perception sensorielle de la minéralité. 62 professionnels suisses et 19 professionnels bourguignons ont noté le niveau d’exemplarité de la minéralité de 80 Chassela…
Etude du rôle de STING dans la biologie des lymphocytes T CD4 : application en immunothérapie anticancéreuse
2021
Recognition of danger signals by intracellular or extracellular receptors expressed by innate immune cells is crucial for the establishment of an effective adaptive immune response. STING (Stimulator of Interferon Genes) is a protein located in the endoplasmic reticulum discovered in 2008 as being essential for the detection of cytosolic DNAs and the establishment of antiviral immune response mediated by type I interferons (IFNs). The STING protein also plays a key role in spontaneous anti-tumor immune responses and the administration of STING ligands in tumor-bearing mice favors tumor growth control. These observations have been verified in clinical trials in patients with melanoma, illust…
The hidden face of expertise! Representations and descriptions of wines by different groups of experts in a vineyard in full evolution : the Beaujola…
2022
The Beaujolais vineyard is today in full evolution thanks to a policy of upgrading and moving upmarket. This evolution leads to the development of new mentions within the vineyard. This evolution impacts the Beaujolais wines but also the wine experts who are in the heart of making, selling and promoting these wines. Wine expertise has been studied extensively over the past twenty years. Most studies have focused on experts as a unified group versus novices to understand the effect of expertise on the knowledge and abilities of experts. However, it appears that within this unity, there are several types of experts with different backgrounds, knowledge, experiences, and professions: wine make…
Développement de méthodes de référence pour les biomarqueurs du bilan lipidique : application au contrôle qualité en biologie clinique
2013
Reliable measurements in medical biology are essential for early screening and appropriate follow-up of patients. Ensuring metrological traceability of clinical measurements to higher order reference methods or certified reference materials enables to obtain comparable results over time and between different laboratories that could use different methods to quantify the same biomarker.In this study, reference methods were developed and validated for lipid profile biomarkers (total cholesterol, triglycerides, HDL-C, and LDL-C). Their value added in proficiency testing schemes was demonstrated against consensus mean. They were also used to characterize a certified reference material (CRM) that…
Développement et évaluation d'une méthode fondée sur la PCR temps réel pour la caractérisation des bioaérosols : application au groupe des actinomycè…
2013
Actinomycetes are ubiquitous bacteria and some can be potentially pathogen for Humans in the air of some working areas. It’s notably the case in composting plants where bacteria concentrations can reach high values. Workers exposure to these inhalable bioaerosols can be source of various diseases (hypersensitivity pneumonitis notably). Although this problem is admitted, bibliography reveals a lack of knowledge about risk assessment: currently, none global method for bioaerosols sampling and analysis is standardized. So much that neither dose-effects relationship for most of these bacteria, nor Threshold Limit Value exists. Traditional methods, that are used, have some drawbacks (concentrati…
Indigenous Listeria spp. in biowastes and during composting
2007
International audience
Ether-lipid and docosahexaenoic acid (DHA) levels in erythrocytes of patients with glaucoma
2008
International audience; Purpose: : Neuronal tissues such as the brain and the retina are known to contain elevated amounts of phospholipids with a vinyl-ether double bond (ether-lipids or plasmalogens) as well as high concentrations of long-chain omega-3 polyunsaturated fatty acids (docosahexaenoic acid or DHA). Abnormal blood levels of ether-lipids and DHA have been associated with several neurological disorders such as Alzheimer Disease. Since many observations bring up the idea of pathogenetic similarities between Alzheimer Disease and glaucoma, the aim of our work was to check whether ether-lipid and DHA levels were modified in glaucoma patients. Methods: : Blood samples were collected …