Search results for "STING"

Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments

2021

Muscle wasting, i.e., cachexia, frequently occurs in cancer and associates with poor prognosis and increased morbidity and mortality. Anticancer treatments have also been shown to contribute to sustainment or exacerbation of cachexia, thus affecting quality of life and overall survival in cancer patients. Pre-clinical studies have shown that blocking activin receptor type 2 (ACVR2) or its ligands and their downstream signaling can preserve muscle mass in rodents bearing experimental cancers, as well as in chemotherapy-treated animals. In tumor-bearing mice, the prevention of skeletal and respiratory muscle wasting was also associated with improved survival. However, the definitive proof tha…

Application of artificial neural network and genetic algorithm to forecasting of wind power output

2007

Posting and agency work in British construction and hospitality: the role of regulation in differentiating the experiences of migrants

2017

This article engages with IHRM debates on the transnational regulation of labour, exploring how migration policy and work fragmentation affect employment dynamics in multi-employer settings. It dra...

Alteration-Induced Volcano Instability at La Soufrière de Guadeloupe (Eastern Caribbean)

2021

International audience; Volcanoes are unstable structures that deform laterally and frequently experience mass wasting events. Hydrothermal alteration is often invoked as a mechanism that contributes significantly to volcano instability. We present a study that combines laboratory experiments, geophysical data, and large-scale numerical modeling to better understand the influence of alteration on volcano stability, using La Soufrière de Guadeloupe (Eastern Caribbean) as a case study. Laboratory experiments on variably altered (advanced argillic alteration) blocks show that uniaxial compressive strength, Young's modulus, and cohesion decrease as a function of increasing alteration, but that …

Nonlinear black-box models for short-term forecasting of air temperature in the town of Palermo

2011

Weather data are crucial to correctly design buildings and their heating and cooling systems and to assess their energy performances. In the intensely urbanized towns the effect of climatic parameters is further emphasized by the Urban Heat Island (UHI) phenomenon, known as the increase in the air temperature of urban areas, compared to the one measured in the extra-urban areas. The analysis of the heat island needs detailed local climate data which can be collected only by a dedicated weather monitoring system. The Department of Energy and Environmental Researches of the University of Palermo (Italy) has built up a weather monitoring system that works 24 hours per day and makes data availa…

Usability aspects of Network Element Management Unit

2004

Uztura paradumu, fiziskās aktivitātes un miera vielmaiņas intensitātes izvērtējums jaunu cilvēku grupā

2016

Liekais svars un aptaukošanās pazemina dzīves kvalitāti un ir par iemeslu daudzām saslimšanām: diabētam, koronārajām sirds slimībām, onkoloģiskajām saslimšanām, metabolajam sindromam. Pētījuma mērķis ir izvērtēt uztura, fiziskās aktivitātes (FA) un miera vielmaiņas intensitātes (RMR) korelāciju ar ķermeņa tauku masu jaunu, pieaugušu, klīniski veselu cilvēku grupā. Pētījuma gaitā tika analizēta izmeklējamo personu 3 dienu uztura dienasgrāmata, fiziskā aktivitāte noteikta ar anketēšanas metodi, veikti antropometriskie mērījumi un reģistrēta miera vielmaiņas intensitāte ar netiešās kalorimetrijas metodi. Pētījuma rezultātā tika secināts, ka respondentu uzturā ir samazināts relatīvais ogļhidrāt…

International Assessment Surveys of Educational Achievement in Developing Countries : Why Education Economists Should Care

2015

International audience; This paper reviews the most known international assessment studies that are conducted in the context of poor countries and highlights the lack of empirical evidence on the degree to which the contents of the tests really match countries' curricula. To illustrate, the paper evaluates the sensitivity of an international testing instrument by comparing the responses of students in two consecutive grades on the same battery of tests. Using propensity score matching to control for student and teacher characteristics, the results show that the tests are not grade sensitive, which raises the question of the validity of many empirical works that are based on similar instrume…

Comparison of inter-trial recovery times for the determination of critical power and W' in cycling

2017

Critical Power (CP) and W’ are often determined using multi-day testing protocols. To investigate this cumbersome testing method, the purpose of this study was to compare the differences between the conventional use of a 24-h inter-trial recovery time with those of 3 h and 30 min for the determination of CP and W’. Methods: 9 moderately trained cyclists performed an incremental test to exhaustion to establish the power output associated with the maximum oxygen uptake (p V O2max), and 3 protocols requiring time-to-exhaustion trials at a constant work-rate performed at 80%, 100% and 105% of p VO2max. Design: Protocol A utilised 24-h inter-trial recovery (CP24/W’24), protocol B utilised 3-h in…

Psychometric testing of the Norwegian version of the questionnaire Family Satisfaction in the Intensive Care Unit (FS-ICU-24)

2018

Bjørg Dale,1 Gro Frivold2 1Centre for Caring Research, Southern Norway, University of Agder, Faculty of Health and Sport Sciences, Grimstad, Norway; 2University of Agder, Faculty of Health and Sport Sciences, Grimstad, Norway Introduction: The questionnaire, Family Satisfaction in the Intensive Care Unit (FS-ICU-24), was developed to assess relatives’ satisfaction with care and involvement in decision-making processes when a close family member stays in the ICU Aim: This study was aimed at describing the translation and exploring the psychometric properties of the Norwegian version of the questionnaire. Methods: The study design was a cross-sectional survey. After trans…