Search results for "STRAIN"
showing 10 items of 1955 documents
Shape optimization in contact problems based on penalization of the state inequality
1986
The paper deals with the approximation of optimal shape of elastic bodies, unilaterally supported by a rigid, frictionless foundation. Original state inequality, describing the behaviour of such a body is replaced by a family of penalized state problems. The relation between optimal shapes for the original state inequality and those for penalized state equations is established. peerReviewed
Prediction of harmful variants on mitochondrial genes : Test of habitat-dependent and demographic effects in a euryhaline fish
2017
Both effective population size and life history may influence the efficacy of purifying selection, but it remains unclear if the environment affects the accumulation of weakly deleterious nonsynonymous polymorphisms. We hypothesize that the reduced energetic cost of osmoregulation in brackish water habitat may cause relaxation of selective constraints at mitochondrial oxidative phosphorylation (OXPHOS) genes. To test this hypothesis, we analyzed 57 complete mitochondrial genomes of Pungitius pungitius collected from brackish and freshwater habitats. Based on inter- and intraspecific comparisons, we estimated that 84% and 68% of the nonsynonymous polymorphisms in the freshwater and brackish …
Pareto frontier in economic-statistical design of a dynamic c chart
2015
The present paper proposes an economic-statistical multi-objective design procedure for a dynamic c control chart. In detail, a mixed integer non-linear constrained mathematical model is formulated to solve the treated problem, whereas the Pareto frontier is described by the ε-constraint method. To show the employment of the proposed procedure a numerical case is solved and the related considerations are given.
An Hypervolume based constraint handling technique for multi-objective optimization problems
2011
Formulation of structural optimization problems usually leads to the individuation of one or more objective functions to be minimized under different constraints. Many multi-objective evolutionary algorithms are approached by a Pareto-compliant ranking method, where no a priori information on the problem is needed and the concept of non-dominated solutions is used. In this paper a constraint handling technique based on the concept of hypervolume indicator is presented. Initially proposed to compare different multi-objective algorithms hypervolume indicator is the only single set quality measure to reflects the dominance of solution’s sets. The constraint handling technique proposed use an e…
Misalignment of Spectral Data: Constrained Optimization in a Functional Data Analysis Framework
2022
Across several branches of sciences, a large number of applications involves data represented as functions and curves, for which functional data analysis can play a central role in solving a variety of problem formulations. With some thecnologies, the obtained data are spectra containing a vast amount of information concerning the composition of a sample: in order to infer the chemical composition of the materials from spectra, functional data analysis offers a valuable mean for characterizing the spectral response through identification of peaks position and intensity. The collection of data from different measurement may exhibit similar peak pattern but display misalignment in their peaks…
H2-M polymorphism in mice susceptible to collagen-induced arthritis involves the peptide binding groove.
1996
The ability to develop type II collagen (CII)-induced arthritis (CIA) in mice is associated with the major histocompatibilityI-A gene and with as yet poorly defined regulatory molecules of the major histocompatibility complex (MHC) class II antigen processing and presentation pathway. H2-M molecules are thought to be involved in the loading of antigenic peptides into the MHC class II binding cleft. We sequencedH2-Ma, H2-Mb1, andH2-Mb2 genes from CIA-susceptible and-resistant mouse strains and identified four differentMa andMb2 alleles and three differentMb1 alleles defined by polymorphic residues within the predicted peptide binding groove. Most CIA-resistant mouse strains share commonMa, M…
FGFR2mutation in 46,XY sex reversal with craniosynostosis
2015
Patients with 46,XY gonadal dysgenesis (GD) exhibit genital anomalies, which range from hypospadias to complete male-to-female sex reversal. However, a molecular diagnosis is made in only 30% of cases. Heterozygous mutations in the human FGFR2 gene cause various craniosynostosis syndromes including Crouzon and Pfeiffer, but testicular defects were not reported. Here, we describe a patient whose features we would suggest represent a new FGFR2-related syndrome, craniosynostosis with XY male-to-female sex reversal or CSR. The craniosynostosis patient was chromosomally XY, but presented as a phenotypic female due to complete GD. DNA sequencing identified the FGFR2c heterozygous missense mutatio…
Effects of muscle activation on shear between human soleus and gastrocnemius muscles
2015
Lateral connections between muscles provide pathways for myofascial force transmission. To elucidate whether these pathways have functional roles in vivo, we examined whether activation could alter the shear between the soleus (SOL) and lateral gastrocnemius (LG) muscles. We hypothesized that selective activation of LG would decrease the stretch-induced shear between LG and SOL. Eleven volunteers underwent a series of knee joint manipulations where plantar flexion force, LG, and SOL muscle fascicle lengths and relative displacement of aponeuroses between the muscles were obtained. Data during a passive full range of motion were recorded, followed by 20° knee extension stretches in both pass…
Gastrocnemius tendon length and strain are different when assessed using straight or curved tendon model
2011
The present study investigated the effects of tendon curvature on measurements of tendon length using 3D-kinematic analysis. Curved and straight tendon models were employed for assessing medial gastrocnemius tendon length and strain during hopping (N = 8). Tendon curvature was identified using small reflective markers placed on the skin surface along the length of the tendon and a sum of vectors between the markers from the calcaneous up to the marker at the origin of tendon was calculated. The straight tendon was defined as a length of vector from the calcaneous to the marker at the origin of tendon. The curved tendon method yielded 5.0 ± 1.3 mm longer tendon (p < 0.001) than the straight …
Stiffness and Reinforcement Effect of electrical Resistance Strain Gauges
2007
: The increasing use of low-modulus materials, on which the reinforcement effect of the electrical resistance strain gauge is not negligible, has re-opened the research interest into this issue. This study deals with the evaluation of stiffness, and of the strain gauge Young's modulus involved in the estimation of both the global and the local reinforcement effect; the relationship between the strain gauge stiffness and the local reinforcement effect is also analysed. In particular, the experimental technique used to determine the stiffness of some commercial strain gauges is described. The results show that the strain gauge stiffness alone does not permit an accurate evaluation of the loc…