Search results for "STRATEGY"
showing 10 items of 2256 documents
Cross-border Cultural Cooperation as the Principle Paradiplomacy Form: Evidence from the Czech-Polish Borderland
2021
Microprojects are an important part of Interreg programmes. This article presents areas of cooperation and categories of actors who have been active in submitting and implementing these microprojects in the Czech-Polish borderland. It identifies 11 thematic areas of microprojects, which mainly support people-to-people projects in the field of culture. The most active microproject actors are local govern-ments, while the participation of non-public sector actors has generally rather stagnated since 2004. Cross-border cooperation, based on the use of microproject schemes, is a decisive part of the paradip-lomacy of small and medium-sized municipalities in the Czech-Polish borderland. The rol…
Small molecule DNA-PK inhibitors as potential cancer therapy: a patent review (2010–present)
2021
Introduction: DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being investigated for potential anticancer treatment in clinical trials.Area covered: This review aims to give an overview of patents published since 2010 by analyzing the patent space and structure features of scaffolds used in those patents. It also discusses the recent clinical developments and provides perspectives on future challenges and directions in this field.Expert opinion: As a key component of the DNA damage response (DDR) pathway, DNA-PK appears to be a viable drug target for anticancer therapy. The clinical investi…
An empirical study of lean production in ceramic tile industries in Spain
2006
PurposeTo determine the degree of use of some of the most representative lean production (LP) practices in the Spanish ceramic tile industry, their relationship with plant size and their effect on the operational performance of the companies in the sector.Design/methodology/approachA questionnaire was developed for data collection. Findings are presented from 76 companies (79.17 per cent of the total sample) that specialise in single firing ceramics.FindingsIn the sector under study, there is one set of practices that have as yet scarcely been implemented (group technology, kanban, reduction of set‐up time, development of multi‐function employees and visual factory) and another set whose us…
SUP R DSS: A sustainability-based decision support & system for road pavements
2019
Road pavement community members are increasingly becoming aware of the need to incorporating the principles of sustainable development into the sector. Policies are also going in this direction and as a consequence in the recent years researchers and practitioners are coming up with new materials, technologies and practices designed to reduce the negative impacts of their activities in the surroundings. Within this framework the road pavements sector is witnessing a paradigm shift towards the development of pavement technologies incorporating high-content of recycled materials, as well as best practices to decrease the overall carbon footprint. These are all promising solutions that to the …
Energy saving in wastewater treatment plants: A plant-generic cooperative decision support system
2017
Abstract In Europe, the analysis of Waste Water Treatment Plants (WWTPs) shows a significant energy efficiency potential (up to 25%). Optimistically, plant managers assess their plant efficiency once or twice per year. Consequently, the time gap between an inefficiency and its detection produces avoidable operational costs. Although the installation of multiple on-line sensors can provide detailed energy information, for a human operator it is unrealistic to analyse the produced data in a satisfactory time-scale. This paper proposes a cooperative tool for energy saving that remotely accesses and evaluates WWTP databases to produce daily energy assessment reports. The novelty of this decisio…
Determining the implementation order of a general plan by using a multicriteria method
1998
We describe a real-life application of a new multicriteria method in the context of assisting the decision-making for a general plan in the municipality of Kirkkonummi in Uusimaa, Finland. At the time our group started working on the problem, a proposal for an overall plan had already been completed, but the order in which different regional parts of the plan should be implemented needed to be considered based on the environmental impact assessment (EIA) procedure. The EIA procedure generated a large amount of data about the different impacts of the alternatives. For this group decision making problem we developed the SMAA-3 decision support method which does not require any explicit prefer…
An Open Innovation Decision Support System to Select a Biopharmaceutical R&D Portfolio
2015
Drugs available in the market today, selected several years ago under very uncertain future scenario, have experienced a long and expensive process of research and development carried out following both a closed and an open innovation path. To support this critical selection process, we propose a Decision Support System, able to choose among different candidates the most promising drugs along their best development path. The Decision Support System, based on a real options portfolio optimization model, mapping tools, and what-if rules as well, has been applied to a numerical example available in literature, and the research findings show interesting managerial and academic implications. Cop…
A decision support system based on multisensor data fusion for sustainable greenhouse management
2018
The sustainable exploitation of natural resources is nowadays an important challenge for governments and institutions, considering the expected increase of the world population. In order to respond to this emergent criticality, the principles of green economy have been introduced in the European policy discussion to achieve a good compromise between the sustainability and the profitability of productions by increasing the efficiency of farming operations. Such approach poses some technical and financial challenges for small-sized enterprises because they generally do not possess adequate internal knowledge, nor they can acquire external expertise due to their budget restrictions. Decision S…
Selecting sewage sludge treatment alternatives in modern wastewater treatment plants using environmental decision support systems
2015
The importance of the sewage sludge treatment within the field of wastewater treatment plants (WWTPs) suggests new dimensions of analysis where the relevance of economic criteria combined with the associated environmental issues are increasing the sludge management complexity. For supporting the decision process and for comparative purposes, this study assesses five alternative configurations for sludge treatment, namely: mesophilic and termophilic anaerobic digestion plus composting, incineration, gasification, and supercritical water oxidation (SCWO). The global warming potential (GWP) and the annual cash flow of each alternative are used to estimate a composite indicator for each alterna…
Ranking and comparing key factors causing time-overruns in on-site construction
2022
For years, the construction industry has looked for ways to avoid time-overruns in construction. Despite previous research mapping the factors affecting time performance, site-managers have difficulties in reducing the time-overrun. In order to create a clearer guidance on how to control time-performance, this study investigates the resource related factors because they are within the site-manager’s control. Three Case studies were followed and a survey including 36 participants where conducted. Both investigated and ranked the likelihood of delay due to the seven different resource factors. The ranking of the resource factors was identified as: (1) Construction design, (2) Connecting works…