Search results for "STRATEGY"
showing 10 items of 2256 documents
Molecular profiling of pancreatic neuroendocrine tumors (pNETS) and the clinical potential
2018
Abstract: Introduction: Pancreatic neuroendocrine tumors (pNETs) represent a small part of pancreatic neoplasms, and the knowledge about their indolent clinical course remains a subject of investigation. They occur sporadically or as part of familial cancer syndromes and are classified by WHO in 3 categories. There is ongoing research to understand their molecular profiling and leading mutations.Areas covered: The aim of this review is to clarify the overall aspects of tumorigenesis, to expose the latest developments in understanding the course of the disease and the possible therapeutic implications of these. The review also discusses functional and non-functional pNETs and associated inhe…
PCSK9-D374Y mediated LDL-R degradation can be functionally inhibited by EGF-A and truncated EGF-A peptides: An in vitro study.
2019
Abstract Background and aims Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low density lipoprotein receptor (LDLR) through the LDLR epidermal growth factor-like repeat A (EGF-A) domain and induces receptor internalization and degradation. PCSK9 has emerged as a novel therapeutic target for hypercholesterolemia. Clinical studies with PCSK9 inhibiting antibodies have demonstrated strong LDL-c lowering effects, but other therapeutic approaches using small molecule inhibitors for targeting PCSK9 functions may offer supplementary therapeutic options. The aim of our study was to evaluate the effect of synthetic EGF-A analogs on mutated (D374Y) PCSK9-D374Y mediated LDLR degradatio…
Computational Fluid Dynamics Suggests Ecological Diversification among Stem-Gnathostomes.
2020
Summary The evolutionary assembly of the vertebrate bodyplan has been characterized as a long-term ecological trend toward increasingly active and predatory lifestyles, culminating in jawed vertebrates that dominate modern vertebrate biodiversity [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 ]. This contrast is no more stark than between the earliest jawed vertebrates and their immediate relatives, the extinct jawless, dermal armor-encased osteostracans, which have conventionally been interpreted as benthic mud-grubbers with poor swimming capabilities and low maneuverability [ 9 , 10 , 11 , 12 ]. Using computational fluid dynamics, we show that osteostracan headshield morphology is compatible with a dive…
Genotyping strategy of SMAD-3 rs3825977 gene variant for a differential management of ascending aorta aneurysm in women people: Gender oriented diagn…
2020
Abstract Background and objectives The research of opportune strategies for facilitating the management of complex pathologies, such as ascending aorta aneurysm (AAA), currently represents the principal object of clinicians, clinical pathologists included. Herein, we propose genotyping of gene variants related to TGF-β pathway as useful strategy to improve the complex AAA management, exclusively based on imaging evaluations. Precisely, we investigated four functional SNPs in SMAD and VEGF genes, encoding molecules able to modulate functions and cross-talks of TGF-β pathway. Populations and methods Our study included 92 individuals (70 men (76%) and 22 (24%) women; mean age: 71.4 ± 2.6 years…
An exploration of digital ride-hailing multisided platforms' market dynamics: empirical evidence from the Uber case study
2020
PurposeThe purpose of this paper is to experiment a dynamic performance management (DPM) approach to explore and assess the business dynamics of digital ride-hailing platforms with a focus on both supply and demand sides, and related interplays.Design/methodology/approachThe research adopts the DPM framework supported by simulation-based experimentations for developing a systemic case interpretation of Uber Inc. and its specific business complexity.FindingsThe emerging scenario analysis reveals that changes in the commission percentage for drivers and cutting prices for customers (car hailers) by competitors have significant impacts on the car-hailing industry.Originality/valueDPM and assoc…
Activisme et proxy fight. Quand les actionnaires déclarent la guerre au management
2009
Les attentes des actionnaires minoritaires sont relativement heterogenes : les salaries ou les fournisseurs qui detiennent des actions ne sont pas uniquement preoccupes par les dividendes ou les plus-values, contrairement aux actionnaires patrimoniaux. Ces derniers, qui peuvent etre insatisfaits par certaines decisions strategiques ou operationnelles prises par les dirigeants, ont la possibilite d’agir pour proteger leurs interets, en s’engageant notamment dans une bataille de procuration. Dans cet article, les auteurs insistent sur les principales difficultes rencontrees par les actionnaires contestataires lors de ces batailles, sur les facteurs cles de succes, ainsi que sur les consequenc…
An Easy Game? Experiences of ‘Homecoming’ in the Post-Socialist Context of Croatia and the Czech Republic
2016
The obstacles that often accompany remigration, planned and imagined as a ‘homecoming’, are seldom the topic of investigation in migration studies. Returning is not always an ‘easy game’. To explore this aspect of remigration, this chapter intends to focus on narratives of return produced mainly by so-called co-ethnic migrants who moved back to Croatia and the Czech Republic during the past two decades of post-socialist transformation. The empirical base of the chapter draws on the experiences and struggles accompanying remigration, and of arrival and acceptance in the respective society as described by returnees in biographical interviews. Attention is given to everyday social interaction …
Reviving the lost spaces under urban highways and bridges: an empirical study
2019
Purpose The fast development of urban movement infrastructures has created neglected urban places in cities. This study aims to provide users’ preferences for designing lost spaces that are a by-product of elevated urban highways (UHs) and bridges to develop a conceptual model for better environmental design. Design/methodology/approach This research is conducted by a combination of both qualitative and quantitative methods. In the first phase, to explore the citizen’s environmental preferences based on the Q-sort technique and in-depth interviews, the ideas of 50 users were considered up to data saturation. The preferences of people for designs under urban bridges were extracted by conten…
Developing an Analytical Framework for Analyzing and Comparing National E-Government Strategies
2020
Part 1: E-Government Foundations; International audience; Across the world, e-government strategies are developed for the effective digitalization of the public sector. They offer governments a framework for dealing with challenges such as technical and legal interoperability and collaboration between public and private sector stakeholders, and for promoting a future vision for a digital public sector. Since e-government strategies are policy document and, thus, likely to convey biased perspectives, analyses of these strategies can yield insights into these biases and different perspectives on public sector digitalization. Until now, there has been no widely recognized framework for systema…
"So you're saying": the interrogation of Jordan Peterson
2021
<p class="p1">In this article, I analyse the infamous Cathy Newman interview with Jordan Peterson on the 16th of January 2018 and subsequent viewer comments on Channel 4's YouTube channel. My first hypothesis is that Newman's frequent attribution of statements to Peterson using the now notorious "so you are saying" gambit (YSG) is what triggered outrage among Peterson's followers, which, in turn, generated media interest. My second hypothesis is that the interview is best understood as a series of Face threats by Newman on Peterson using the YSG. To ascertain if my hypotheses are true, I performed corpus linguistic analyses on the interview and comments to provide objective descriptio…