Search results for "STRESS"
showing 10 items of 6278 documents
Phase behavior of aqueous solutions of bovine serum albumin in the presence of dextran, at rest, and under shear.
2006
The demixing conditions for aqueous solutions of bovine serum albumin (BSA, fraction V) and for joint solutions of BSA plus dextran (DEX, M(w) = 2000 kg/mol) were determined by turbidimetric measurements as a function of composition, temperature, and shear rate. Aqueous solutions of BSA phase separate upon heating. Within the region of BSA concentrations between 0.05 and 32 wt %, the demixing temperature, T1, falls from ca. 65 degrees C to an almost constant value of 45 degrees C. Adding DEX to the BSA solutions reduces the homogeneous region of the mixture drastically where the amount of DEX required to lower T1 to 25 degrees C decreases rapidly as the concentration of BSA is raised. Exper…
Heat shock and Cd2+ exposure regulate PML and Daxx release from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 an…
2003
Nuclear domains called ND10 or PML bodies might function as nuclear depots by recruiting or releasing certain proteins. Although recruitment of proteins through interferon-induced upregulation and SUMO-1 modification level of PML had been defined, it is not known whether release of proteins is regulated and has physiological consequences. Exposure to sublethal environmental stress revealed a sequential release of ND10-associated proteins. Upon heat shock Daxx and Sp100 were released but PML remained, whereas exposure to subtoxic concentrations of CdCl2 induced the release of ND10-associated proteins, including PML, with Sp100 remaining in a few sites. In both cases,recovery times were simil…
Comprehensive analysis of forty yeast microarray datasets reveals a novel subset of genes (APha-RiB) consistently negatively associated with ribosome…
2014
Background The scale and complexity of genomic data lend themselves to analysis using sophisticated mathematical techniques to yield information that can generate new hypotheses and so guide further experimental investigations. An ensemble clustering method has the ability to perform consensus clustering over the same set of genes from different microarray datasets by combining results from different clustering methods into a single consensus result. Results In this paper we have performed comprehensive analysis of forty yeast microarray datasets. One recently described Bi-CoPaM method can analyse expressions of the same set of genes from various microarray datasets while using different cl…
Teachers’ responses to children in emotional distress: A study of co-regulation in the first year of primary school in Norway
2020
The purpose of this study was to explore how first-grade teachers respond to pupils in emotional distress within the framework of co-regulation. Co-regulation in this context refers to an adult–chi...
Comprehensive analysis of forty yeast microarray datasets reveals a novel subset of genes (APha-RiB) consistently negatively associated with ribosome…
2014
This article has been made available through the Brunel Open Access Publishing Fund. Background: The scale and complexity of genomic data lend themselves to analysis using sophisticated mathematical techniques to yield information that can generate new hypotheses and so guide further experimental investigations. An ensemble clustering method has the ability to perform consensus clustering over the same set of genes from different microarray datasets by combining results from different clustering methods into a single consensus result. Results: In this paper we have performed comprehensive analysis of forty yeast microarray datasets. One recently described Bi-CoPaM method can analyse express…
Numerical modelling of fatigue crack initiation of martensitic steel
2010
Numerical simulation of micro-crack initiation that is based on Tanaka-Mura micro-crack nucleation model is presented. Three improvements were added to this model. Firstly, multiple slip bands where micro-cracks may occur are used in each grain. Second improvement deals with micro-crack coalescence by extending existing micro-cracks along grain boundaries and connecting them into a macro-crack. The third improvement handles segmented micro-crack generation, where a micro-crack is not nucleated in one step like in Tanaka-Mura model, but is instead generated in multiple steps. Numerical simulation of crack-initiation was performed with ABAQUS, using a plug-in that was written specially for ha…
Structuring of polymer blends in simple shear flow
1990
A simplified model for the formation of steady state structure of discrete domains in polymer blends is established for simple shear flow. It is assumed that the domain size distribution, which results from an equilibrium between breakup processes and coalescence processes, may be divided in small and stable spherical domains and large and unstable ellipsoidal domains. Based on simplified rate balances and an expression for domain deformation rate the volume fraction of large domains and the large and small semiaxes of the ellipsoids are expressed as functions of volume fraction and shear rate/shear stress. The ability of the model to simulate actual behaviour is tested against quantitative…
Crack growth in fillet welded steel joints subjected to membrane and bending loading modes
2020
Abstract The present paper presents the results from extensive studies of the fatigue damage evolution in fillet welded steel joints subjected to Constant Amplitude (CA) stress under membrane and bending loading modes. The welded joints in question are F class details (category 71) with plate thicknesses ranging from 25 to 32 mm. The steel quality is a medium strength carbon manganese steel. Crack growth histories for the shallow semi-elliptical shaped cracks emanating from the weld toe are obtained by an Alternating Current Potential Drop (ACPD) technique. These growth histories are presented in detail and modelled by Linear Elastic Facture Mechanics (LEFM). The calculations follow the rec…
2021
In humans and mammals, effort-based decision-making for monetary or food rewards paradigms contributes to the study of adaptive goal-directed behaviours acquired through reinforcement learning. Chronic distress modelled by repeated exposure to glucocorticoids in rodents induces suboptimal decision-making under uncertainty by impinging on instrumental acquisition and prompting negative valence behaviours. In order to further disentangle the motivational tenets of adaptive decision-making, this study addressed the consequences of enduring distress on relevant effort and reward-processing dimensions. Experimentally, appetitive and consummatory components of motivation were evaluated in adult C…
The Interaction Between Physical and Psychosocial Stressors
2020
Do physical and psychosocial stressors interact to increase stress in ways not explainable by the stressors alone? A preliminary study compared participants’ stress response while subjected to a physical stressor (reduced or full physical load) and a predetermined social stressor (confronted by calm or aggressive behavior). Salivary cortisol samples measured endocrine stress. Heart rate variability (HRV) and electrodermal activity (EDA) measured autonomic stress. Perceived stress was measured via discomfort and stress state surveys. Participants with a heavier load reported increased distress and discomfort. Encountering an aggressive individual increased endocrine stress, distress levels, …