Search results for "STROKE"

Incidences de l’ischémie cérébrale sur la fonction et la sensibilité cardiaques à l’ischémie

2019

For years, the relationship between cardiac and neurological ischemic events has been limited to overlapping pathophysiological mechanisms and common risk factors. However, acute stroke may induce dramatic changes in cardiovascular function.The aim of this study was to evaluate how prior cerebrovascular lesions affect myocardial function and signaling in vivo and ex vivo, and how they influence cardiac vulnerability to ischemia-reperfusion injury and the expression of cardiac genes and proteins involved in cardioprotective pathways.Thus, in our work, we studied cardiac function in a rat stroke model induced by cerebral embolization.The main results show that experimental stroke 1/ impaired …

La “Stimolazione transcranica Random Noise” (tRNS) e la riabilitazione motoria dell’arto superiore nel paziente in fase subacuta di ictus ischemico.

"RANDOM NOISE TRANSCRANIAL STIMULATION" (TRNS) AND MOTOR REHABILITATION OF THE UPPER LIMB IN SUBACUTE ISCHEMIC STROKE PATIENTS. BACKGROUND Upper limb impairment is a common outcome after stroke. New rehabilitative interventions partially failed to show a superior effect compared to standard therapy. The present study focuses on the effect of tNRS in the sub-acute stage after stroke. The primary aim is to evaluate the combined use of TRNS with the GRASP in subacute ischemic stroke patients. METHODS A double-blind RCT, approved by local committee, was performed. Patients with upper-limb impairment were recruited 1 to 6 weeks after stroke. Participants were randomly allocated to two groups: GR…

Global Impact of the COVID-19 Pandemic on Cerebral Venous Thrombosis and Mortality

2022

[Background and Purpose] Recent studies suggested an increased incidence of cerebral venous thrombosis (CVT) during the coronavirus disease 2019 (COVID-19) pandemic. We evaluated the volume of CVT hospitalization and in-hospital mortality during the 1st year of the COVID-19 pandemic compared to the preceding year.

Cholesterol level and hemorrhagic transformation after ischemic stroke

2009

Update on mechanism and therapeutic implications of spinal cord stimulation and cerebral hemodynamics: A narrative review

2017

Spinal cord stimulation (SCS) is well known for its early role in the management of chronic pain, mainly failed back surgery syndrome (FBSS), spasticity, and bowel and bladder dysfunction. In more recent years, SCS has been proposed for patients suffering from refractory angina or peripheral vasculopathies in order to gain symptom relief, thus indicating some hemodynamic effect on the peripheral circulation. Taking into account this scientific observation, since the late1980s, researchers have started to investigate the potential effect of SCS on cerebral blood flow (CBF) regulation and its possible application in certain pathological settings dealing with vascular pattern dysfunction, such…

Infarctus cérébral et plasticité : focus sur le BDNF

2011

Functional recovery after ischemic stroke largely involves brain plasticity and more accurately its ability to reorganize the neuronal networks spared by the infarct. Studies conducted on animals using different ischemic stroke models have demonstrated that plastic changes are induced by BDNF (Brain-Derived Neurotrophic Factor). Hence, increasing levels of BDNF in the brain is considered a promising therapeutic strategy to reduce post-stroke impairments. In this context, our work had 2 aims: 1) In a rat model, to identify cells involved in the over-production of BDNF and to evaluate the pertinence of the measurement of circulating BDNF levels to estimate brain BDNF levels; 2) In ischemic st…

Stroke subtypes and their possible implication in stroke prevention drug strategies

2014

Thrombotic strokes can affect large or small arteries in the brain. Drugs to prevent atherosclerosis complication such as thrombotic strokes, should be drugs able to prevent the accumulation of intravascular fat, reduce vascular proliferation, decrease blood pressure levels with the resulting shear stress, reduce platelet aggregation, and possibly partially or totally reverse carotid plaques. Any of the commonly used antihypertensive drugs lower the incidence of stroke, with larger reductions in BP resulting in larger reductions in risk. Experimental and clinical data suggest that reducing the activity of the renin-angiotensin aldosterone system (RAAS) may have beneficial effects beyond the…

A precise stroke classification for evaluation of ischemic stroke subtypes and their relation with diabetes: is TOAST the best?

2010

To The Editor: Regarding the study by Turin et al1 performed to estimate the secular time trends in incidence using a population-based stroke registry in Japan, we discuss some issues of potential interest. First, have the authors classified stroke subtypes according TOAST classification or Oxfordshire classification? No mention has been made in the text concerning the classification methodology of ischemic stroke. It is conceivable that applying the TOAST classification2 of ischemic stroke (a classification with clinical, pathophysiological, anatomic, and instrumental basis that is easily applicable and widely validated) could provide a more precise selection of patients with lacunar strok…

Cerebrovascular risk factors and clinical classification of strokes

2005

Cerebrovascular risk represents a progressive and evolving concept owing to the particular distribution of risk factors in patients with ischemic stroke and in light of the newest stroke subtype classifications that account for pathophysiological, instrumental, and clinical criteria. Age represents the strongest nonmodifiable risk factor associated with ischemic stroke, while hypertension constitutes the most important modifiable cerebrovascular risk factor, confirmed by a host of epidemiological data and by more recent intervention trials of primary (HOT, Syst-Eur, LIFE) and secondary (PROGRESS) prevention of stroke in hypertensive patients. To be sure, a curious relationship exists betwee…

Ischemic stroke subtypes and the implications for stroke management

2014

Internal Medicine & Cardioangiology Ward, Dipartimento Biomedico di Medicina Interna & Specialistica, University of Palermo, Italy *Author for correspondence: Tel.: +39 091 6552197; bruno.tuttolomondo@unipa.it