Search results for "SUOLI"

Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women

2018

Recent studies suggest that exercise alters the gut microbiome. We determined whether six-weeks endurance exercise, without changing diet, affected the gut metagenome and systemic metabolites of overweight women. Previously sedentary overweight women (n = 19) underwent a six-weeks endurance exercise intervention, but two were excluded due to antibiotic therapy. The gut microbiota composition and functions were analyzed by 16S rRNA gene amplicon sequencing and metagenomics. Body composition was analyzed with DXA X-ray densitometer and serum metabolomics with NMR metabolomics. Total energy and energy-yielding nutrient intakes were analyzed from food records using Micro-Nutrica software. Serum…

Systemic circulating microRNA landscape in Lynch syndrome

2022

AbstractMicroRNAs (miRs) are non-coding RNA-molecules that regulate gene expression. Global circulating miR (c-miR) expression patterns (c-miRnome) change with carcinogenesis in various sporadic cancers. Therefore, aberrantly expressed c-miRs could have diagnostic, predictive and prognostic potential in molecular profiling of cancers. c-miR functions in carriers of inherited pathogenic mismatch-repair gene variants (path_MMR), also known as Lynch syndrome (LS), have remained understudied. LS cohort provides an ideal population for biomarker mining due to increased lifelong cancer risk and excessive cancer occurrence. Using high-throughput sequencing and bioinformatic approaches, we conducte…

Lynchin oireyhtymän syöpää ehkäisevä seuranta muuttuu geenikohtaiseksi

2020

Asetyylisalisyylihapon tehosta vakuuttavaa näyttöä ja rokote kehitteillä nonPeerReviewed

A lift in snail's gut provides an efficient colonization route for tardigrades.

2022

CD3+ and CD8+ T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer

2022

Simple Summary The lung is the second most common site of metastases in colorectal cancer (CRC). The aim of our study was to evaluate the prognostic value of CD3+ and CD8+ T-cell density based immune cell score (ICS) and PD-1/PD-L1 expression in resected pulmonary metastases of microsatellite stable CRC. The T-cell infiltration was higher in the first pulmonary metastases compared to primary tumour. Pulmonary metastases with high ICS had improved survival compared to low ICS after adjusting for confounders. High tumour cell PD-L1 expression was associated with favourable prognosis. Our results might have clinical feasibility in planning future therapies. Abstract The objective of this study…

Hankamäki

Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.

2018

Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…

Rimboschimento e recupero di soprassuoli forestali artificiali degradati: due aspetti fondamentali per la salvaguardia del territorio montano - Refor…

2015

I fenomeni di dissesto del territorio che in questi ultimi anni sembrano acutizzarsi e recare ferite profonde in tutto il Paese, se da un lato sono quasi endemici data la morfologia e la natura dei terreni, certamente dall'altro sono frutto della mancanza di gestione pianificata e programmatica dell'uso del territorio. Ad esse si unisce il profondo mutamento del tessuto sociale e il conseguente abbandono di molte aree agricole e forestali divenute marginali all'attività economica, cui non ha fatto fronte una politica di salvaguardia del territorio efficace e duratura. Ai problemi di stabilità del territorio montano e collinare, spesso originati da inadeguate attività umane, si è fatto front…

Gut microbiome and atrial fibrillation - results from a large population-based study

2023

Background Atrial fibrillation (AF) is an important heart rhythm disorder in aging populations. The gut microbiome composition has been previously related to cardiovascular disease risk factors. Whether the gut microbial profile is also associated with the risk of AF remains unknown. Methods We examined the associations of prevalent and incident AF with gut microbiota in the FINRISK 2002 study, a random population sample of 6763 individuals. We replicated our findings in an independent case–control cohort of 138 individuals in Hamburg, Germany. Findings Multivariable-adjusted regression models revealed that prevalent AF (N = 116) was associated with nine microbial genera. Incident AF (N = 5…

Elaborazione e validazione di modelli dell’impatto antropico e dei cambiamenti climatici sulle qualità dei suoli in Sicilia, con particolare attenzio…

Il declino della sostanza organica e l’erosione idrica sono due fattori di rischio di degrado del suolo fra i più diffusi in Sicilia. In che misura è possibile contrastarli modificando le attività antropiche ed in particolare quelle in ambito agricolo? Lo scopo della presente ricerca di dottorato è stato quello di mettere a punto dei modelli che permettessero di spiegare le relazioni esistenti fra le azioni dell’uomo in ambito agricolo con la sostanza organica e con l’erosione idrica nei suoli siciliani, tenendo conto anche del clima. Le due indagini sono state svolte separatamente, in parallelo, in aree agricole della Sicilia occidentale per la sostanza organica, sull’intero territorio sic…