Search results for "SUPPRESSION"
showing 10 items of 404 documents
D mesic nuclei
2010
The energies and widths of several D-0 meson bound states for different nuclei are obtained using a D-meson selfenergy in the nuclear medium, which is evaluated in a selfconsistent manner using techniques of unitarized coupled-channel theory. The kernel of the meson-baryon interaction is based on a model that treats heavy pseudoscalar and heavy vector mesons on equal footing, as required by heavy quark symmetry. We find D-0 bound states in all studied nuclei, from C-12 up to Pb-208. The inclusion of vector mesons is the keystone for obtaining an attractive D-nucleus interaction that leads to the existence of D-0-nucleus bound states, as compared to previous studies based on SU(4) flavor sym…
Effective Field Theories for heavy probes in a hot QCD plasma and in the early universe
2016
International audience; There are many interesting problems in heavy-ion collisions and in cosmology that involve the interaction of a heavy particle with a medium. An example is the dissociation of heavy quarkonium seen in heavy-ion collisions. This was believed to be due to the screening of chromoelectric fields that prevents the heavy quarks from binding, however in the last years several perturbative and lattice computations have pointed out to the possibility that dissociation is due to the finite lifetime of a quarkonium state inside the medium. Regarding cosmology, the study of the behavior of heavy Majorana neutrinos in a hot medium is important to understand if this model can expla…
Centrality, rapidity and transverse momentum dependence of J/ψ suppression in Pb-Pb collisions at root(NN)-N-S=2.76TeV
2014
The inclusive J/ψ nuclear modification factor (RAA) in Pb–Pb collisions at √sNN=2.76TeVhas been measured by ALICE as a function of centrality in the e+e−decay channel at mid-rapidity (|y| <0.8) and as a function of centrality, transverse momentum and rapidity in the μ+μ−decay channel at forward-rapidity (2.5 <y <4). The J/ψyields measured in Pb–Pb are suppressed compared to those in ppcollisions scaled by the number of binary collisions. The RAAintegrated over a centrality range corresponding to 90% of the inelastic Pb–Pb cross section is 0.72 ±0.06(stat.) ±0.10(syst.)at mid-rapidity and 0.58 ±0.01(stat.) ±0.09(syst.)at forward-rapidity. At low transverse momentum, significantly larger valu…
Ironic Effects of Thought Suppression: A Meta-Analysis.
2020
The ironic effect of thought suppression refers to the phenomenon in which individuals trying to rid their mind of a target thought ironically experience greater levels of occurrence and accessibility of the thought compared with individuals who deliberately concentrate on the thought (Wegner, 1994, doi:10.1037/0033-295X.101.1.34). Ironic effects occurring after thought suppression, also known as rebound effects, were consistently detected by previous meta-analyses. However, ironic effects that occur during thought suppression, also known as immediate enhancement effects, were found to be largely absent. In this meta-analysis, we test Wegner’s original proposition that detection of immedia…
Demographic and clinical data in acquired hemophilia A
2012
Summary. Background: Acquired hemophilia A (AHA) is a rare autoimmune disease caused by autoantibodies against coagulation factor VIII and characterized by spontaneous hemorrhage in patients with no previous family or personal history of bleeding. Although data on several AHA cohorts have been collected, limited information is available on the optimal management of AHA. Objectives: The European Acquired Hemophilia Registry (EACH2) was established to generate a prospective, large-scale, pan-European database on demographics, diagnosis, underlying disorders, bleeding characteristics, treatment and outcome of AHA patients. Results: Five hundred and one (266 male, 235 female) patients from …
Inhibition of expression of natural UAG suppressor glutamine tRNA in HIV-infected human H9 cells in vitro by Avarol.
1988
HTLV-IIIB-infected H9 cells are shown to contain a high level of the natural UAG suppressor glutamine tRNA(UmUG Gln); this tRNA has been demonstrated to be required for the synthesis of Moloney murine leukemia virus (Mo-MuLV)-encoded protease. After cultivation of HTLV-IIIB-infected H9 cells with Avarol at a concentration (1 microgram/ml), previously found to protect the cells against the cytopathic effects of HTLV-III, an almost complete inhibition of the synthesis of the tRNA(UmUG Gln) was observed. Moreover, we obtained some evidence that the processing of the HTLV-III precursor protein p53 to p24 is inhibited by Avarol in infected cells, suggesting that the compound interferes with the …
Differential display reverse transcription PCR reveals IL-1 induced gene expression patterns in human articular chondrocytes
1995
IL-1 exerts diverse effects on the metabolism of articular chondrocytes, including inhibition of proteoglycan synthesis and stimulation of matrix metallopro teinase synthesis. Therefore it is believed that IL-1 might play an important role in cartilage degradation in osteo- and rheumatoid arthritis. To improve our understanding of IL-1 induced effects on overall gene expression patterns of human articular chondrocytes, wc used a novel mRNA fingerprinting technique: Differential Display Reverse Transcription-PCR (DDRT-PCR) (Liang and Pardee 1992). The reported high sensitivity of this powerful technique promised to enable work with human articular cartilage, a tissue from which only small am…
AISF position paper on liver transplantation and pregnancy: Women in Hepatology Group, Italian Association for the Study of the Liver (AISF)
2016
After the first successful pregnancy in a liver transplant recipient in 1978, much evidence has accumulated on the course, outcomes and management strategies of pregnancy following liver transplantation. Generally, liver transplantation restores sexual function and fertility as early as a few months after transplant. Considering that one third of all liver transplant recipients are women, that approximately one-third of them are of reproductive age (18-49 years), and that 15% of female liver transplant recipients are paediatric patients who have a >70% probability of reaching reproductive age, the issue of pregnancy after liver transplantation is rather relevant, and obstetricians, paedi…
Rodent Animal Research in UTx
2019
The rodents, mouse, and rat represent well-characterized animal sources for basic research in any field of biological sciences. The animals are cheap compared to other type of animals, easy to husbandry, and are extremely well characterized from genetic and physiology point of views, especially when it comes to immunological and reproductive aspects. Availability of gene-modified strains, easy embryo transfer, and the accessibility of specific recombinant proteins and monoclonal antibodies are further advantages. Hence, the first experiments done in the modern era of uterus transplantation used mouse and rat as the main animal models. In this chapter, we describe important key steps of the …
Osteopontin shapes immunosuppression in the metastatic niche.
2014
Abstract The matricellular protein osteopontin (OPN, Spp-1) is widely associated with cancer aggressiveness when produced by tumor cells, but its impact is uncertain when produced by leukocytes in the context of the tumor stroma. In a broad study using Spp1−/− mice along with gene silencing in tumor cells, we obtained evidence of distinct and common activities of OPN when produced by tumor or host cells in a spontaneously metastatic model of breast cancer. Different cellular localization of OPN is associated with its distinct activities, being mainly secreted in tumor cells while intracellular in myeloid cells. OPN produced by tumor cells supported their survival in the blood stream, wherea…