Search results for "SWI"
showing 10 items of 1473 documents
Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences
2021
The specific recognition of AT-rich DNA sequences opens up the door to promising diagnostic and/or therapeutic strategies against gene-related diseases. Here, we demonstrate that amphiphilic PtII complexes of the type [Pt(dmba)(N∧N)]NO3 (dmba = N,N-dimethylbenzylamine-κN, κC; N∧N = dpq (3), dppz (4), and dppn (5)) recognize AT-rich oligonucleotides over other types of DNA, RNA, and model proteins. The crystal structure of 4 shows the presence of significant π-stacking interactions and a distorted coordination sphere of the d8 PtII atom. Complex 5, containing the largest π-conjugated ligand, forms supramolecular assemblies at high concentrations under aqueous environment. However, its aggreg…
Défenseurs du roi : la garde de la cour de Versailles et sa réception à la cour de Dresde-Varsovie à la fin du xviie et dans la première moitié du XV…
2021
According to contemporary historiography, the earliest guard units formed in the fifteenth century, at the same time as mercenary armies. Similar units were created throughout Europe, on the French model. Once the French court was transferred to Versailles, it developed a grandiose ceremonial protocol, which shaped the final form of the royal guard. The latter’s tasks were primarily related to the protection of the king and the court, public buildings and important assemblies, as well as royal property and production centres, but also to the distribution of royal mail and broad official functions. In wartime, however, the guard served as elite military units, joining field troops. The model…
Portfolio diversification in the sovereign credit swap markets
2018
We develop models for portfolio diversification in the sovereign credit default swaps (CDS) markets and show that, despite literature findings that sovereign CDS spreads are affected by global factors, there is sufficient idiosyncratic risk to be diversified. However, we identify regime switching in the times series of CDS spreads and spread returns, and the optimal diversified strategies can be regime dependent. The developed models trade off the CVaR risk measure against expected return, consistently with the statistical properties of spreads. We consider three investment strategies suited for different CDS market participants: for investors with long positions, speculators that hold unco…
Pricing sovereign contingent convertible debt
2018
We develop a pricing model for Sovereign Contingent Convertible bonds (S-CoCo) with payment standstills triggered by a sovereign's Credit Default Swap (CDS) spread. We model CDS spread regime switching, which is prevalent during crises, as a hidden Markov process, coupled with a mean-reverting stochastic process of spread levels under fixed regimes, in order to obtain S-CoCo prices through simulation. The paper uses the pricing model in a Longstaff-Schwartz American option pricing framework to compute future state contingent S-CoCo prices for risk management. Dual trigger pricing is also discussed using the idiosyncratic CDS spread for the sovereign debt together with a broad market index. …
A influência do método de armazenamento na transparência do cristalino de porco
2019
Este artículo se ha publicado de forma definitiva en: http://www.scielo.br/pdf/abo/v82n1/0004-2749-abo-82-01-0056.pdf Purpose: The porcine eye is frequently used as a research model. This paper analyzes the effect of different storage methods on the transparency of pig crystalline lens. Methods: A spectral transmission curve (from 220 to 780 nm) for the crystalline lens was determined experimentally after storage in different conditions: saline solution, formalin, castor oil, and freezing at -80°C. The total transmission in the visible spectrum, which was used as an index of transparency, was calculated from these curves. For comparative purposes, fresh lenses were evaluated and used as con…
Experimental and Numerical Validation of a Wind Gust Facility
2013
The study of a vehicle moving through a lateral wind gust has always been a difficult task due to the difficulties in granting the right similitude. The facility proposed by Ryan and Dominy has been one of the best options to carry it out. In this approach, a double wind tunnel is used to send a lateral moving gust on a stationary model. Using this idea as a starting point, the ISAE has built a dedicated test bench for lateral wind studies on transient conditions. Experimental work has been carried out by means of time-resolved PIV, aiming at studying the unsteady interpenetration of the two flows coming from each wind tunnel. Meanwhile, a 3D CFD model based on URANS was set up, faithfully …
Analyse expérimentale et numérique du comportement de véhicules terrestres en présence d'un vent latéral instationnaire
2013
The automotive manufacturers are nowadays more and more interested in crosswind aerodynamics. Indeed, the driver is subjected every day to strong side air flows, for example when overtaking another vehicle or when passing through a lateral wind wall, generated by terrain topography (as in the case of the passage near the empty space between two buildings).The aerodynamic efforts generated in these situations can lead to undesired lateral deviations,which can be dramatic if the driver is surprised. Different experimental studies, reproducing the effects of a dynamic yaw angle, pointed out the issues of the steady methods, commonly used to qualify the vehicle crosswind behaviour. Little is st…
Vitrification of Immature Porcine Oocytes: Effects of Lipid Droplets, Temperature, Cytoskeleton, and Addition and Removal of Cryoprotectant
1998
Three experiments were conducted to investigate the effects of single-step and stepwise exposure to and removal of cryoprotectant, of temperature, and of a cytoskeletal relaxant on the development of germinal vesicle porcine oocytes to the M-II stage. In experiment I, noncooled cumulus-oocyte complexes (COCs) were treated using single-step/stepwise exposure to ethylene glycol (EG) and removal at 23 or 42 degrees C. Stepwise exposure to EG and dilution at 42 degrees C were found to have a positive effect on the COC developmental rate. In experiment II, also without cooling, COCs were treated with Cytochalasin B at 42 degrees C using single-step and stepwise protocols of exposure to and remov…
A comparative study of mechanical properties of fresh and frozen-thawed porcine intervertebral discs in a bioreactor environment
2016
Abstract Limited availability of fresh intervertebral discs (IVDs) necessitates the use of frozen-thawed samples in biomechanical investigations. Several authors have reported the mechanical properties of frozen-thawed IVDs, but few studies have investigated the effects of storage temperature and cooling rate. The validity and reliability of the applied freezing-thawing procedures are still relatively unknown. The study aims to compare the mechanical responses of fresh porcine IVDs and porcine IVDs, which were frozen at different freezing temperatures with a controlled-rate cooling process and then thawed. The specimens were obtained from pigs aged 6 months. A total of 18 functional spine u…
Jazz in Norway, vols. 1–5
2010
Various artists. 1 CD and liner‐notes booklet per each volume. Herman Records and Norsk jazzarkiv. 2001. Individual volumes: vol. 1, Jazz hot og swing, 1920–1940, HJCD 9001; vol. 2, Sigarett stomp,...