Search results for "SYSTEMS"

Smart and resilient manufacturing in the wake of COVID-19.

2021

Since 2020, manufacturers have been facing unprecedented and extraordinary challenges with the COVID-19 outbreak, which severely disrupted manufacturing operations around the world. Some manufac- turers have shifted gears to help address dire shortages during the coronavirus pandemic. Others were thrown into deep unknowns and faced with the grim prospect of being closed down. We have seen a sprawling network of multinationals and local businesses step in to fill a void by using 3D printers to make personal protective equipment (PPE) such as face shields, respirator masks, nasal swabs and even ventilator parts. Large manufacturers attempted to rejig parts of their production lines to mass-pr…

Big data analytics in healthcare: a systematic literature review

2020

The current study performs a systematic literature review (SLR) to synthesise prior research on the  applicability of big data analytics (BDA) in healthcare. The SLR examines the outcomes of 41 stu...

Creativity and Innovation in Technology-Mediated Journalistic Work : Mapping out Enablers and Constraints

2020

This qualitative study examines creativity and innovation in dispersed, journalistic teams. Specifically, we study the factors enabling and constraining creativity and innovation in journalistic work in technology-mediated settings and explore how technology shapes these phenomena in dispersed journalistic teams. The study is motivated by the media industry’s heightened need for creativity and innovation as well as the changing nature of working life where an increasing amount of work is done via information and communication technologies. By closely examining two journalistic teams and their idea sharing and development processes, this study finds that successful creative work and innovati…

Atypical thrombosis associated with VaxZevria (R) (AstraZeneca) vaccine: Data from the French Network of Regional Pharmacovigilance Centres

2021

The current COVID-19 pandemic is an exceptional health situation including for drug use. As there was no known effective drug for COVID-19 at the beginning of the pandemic, different candidates were proposed. In this short article, we present the French public pharmacovigilance activities during this health crisis. Although COVID-19 is a confounding factor per se, owing to its potential for multi-organ damage including the heart and kidney, the quality of the transmitted data in adverse drug reaction reports, the timeliness of feedback from clinicians, and the real-time pharmacological and medical analysis by the French network of the regional pharmacovigilance centers made it possible to s…

The Association of Schools of Public Health in the European Region Statement on the Erosion of Public Health Systems

2021

"Table 33" of "Measurement of the proton and deuteron structure functions, F2(p) and F2(d), and of the ratio sigma(L)/sigma(T)."

1997

Measurement of R=(SIG(L)/SIG(T)).

PHEA-PLA biocompatible nanoparticles by technique of solvent evaporation from multiple emulsions

2015

Nanocarriers of amphiphilic polymeric materials represent versatile delivery systems for poorly water soluble drugs. In this work the technique of solvent evaporation from multiple emulsions was applied to produce nanovectors based on new amphiphilic copolymer, the α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-polylactic acid (PHEA-PLA), purposely synthesized to be used in the controlled release of active molecules poorly soluble in water. To this aim an amphiphilic derivative of PHEA, a hydrophilic polymer, was synthesized by derivatization of the polymeric backbone with hydrophobic grafts of polylactic acid (PLA). The achieved copolymer was thus used to produce nanoparticles loaded with α toc…

Stabilization of unilamellar catanionic vesicles induced by β-cyclodextrins: A strategy for a tunable drug delivery depot.

2018

The limited stability of catanionic vesicles has discouraged their wide use for encapsulation and controlled release of active substances. Their structure can easily break down to form lamellar phases, micelles or rearrange into multilamellar vesicles, as a consequence of small changes in their composition. However, despite the limited stability, catanionic vesicles possess an attractive architecture, which is able to efficiently encapsulate both hydrophobic and hydrophilic molecules. Therefore, improving the stability of the vesicles, as well as the control on unilamellar structures, are prerequisites for their wider application range. This study focuses on the impact of β-cyclodextrins fo…

Synchronizing the release rates of salicylate and indomethacin from degradable chitosan hydrogel and its optimization by definitive screening design.

2018

Abstract Three types of ionically crosslinked (with citric acid) chitosan discs were loaded with the highly water- soluble drug, sodium salicylate (SS) and the poorly water-soluble drug, indomethacin (Ind). In separate experiments the hydrated discs were immersed in a de-crosslinking solution comprising of different concentrations of calcium chloride, which induced a controlled erosion of the discs, a process which was optimized to synchronize the release rates of the two drugs over a predetermined period of time. The optimization was accomplished by manipulating six factors: chitosan MW, its amount in the formulation, the concentration of the crosslinker agent, the concentration of the de-…

Buccal drug delivery: what's new and what does the future hold?

2014

The buccal mucosa is the stratified squamous epithelial tissue inside lining of the cheeks. It is a favorable site of drug absorption since the tissue is non-keratinized, relatively immobile and strongly supplied with blood by a dense capillary-vessel network; moreover, it is highly tolerant to allergens, resistant to potentially harmful agents and has a relatively low enzymatic activity. The tissue consents quick onset of effect, offers an easily accessible and generally well-accepted site for drug delivery, is a useful route of administration in patients in an unconscious state (e.g., when swallowing is impaired), and is suitable for retentive dosage forms of administration. Buccal mucosa…