Stabilization of unilamellar catanionic vesicles induced by β-cyclodextrins: A strategy for a tunable drug delivery depot.

6533b857fe1ef96bd12b4ec5

RESEARCH PRODUCT

Stabilization of unilamellar catanionic vesicles induced by β-cyclodextrins: A strategy for a tunable drug delivery depot.

Fioretta Asaro Gesmi Milcovich Mario Grassi Filipe E. Antunes

subject

3003 Depot Pharmaceutical Science 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Diffusion Surface-Active Agents Drug Delivery Systems Cyclodextrin Lamellar structure Unilamellar Liposomes chemistry.chemical_classification Catanionic vesicles Cyclodextrin Chemistry Cetrimonium Vesicle beta-Cyclodextrins technology industry and agriculture Temperature Sodium Dodecyl Sulfate Catanionic vesicles; Cyclodextrin; Diffusion; NMR; Self-assembly; 3003 Self-assembly 021001 nanoscience & nanotechnology Catanionic vesicle Controlled release NMR 0104 chemical sciences Chemical engineering Settore CHIM/09 - Farmaceutico Tecnologico Applicativo Drug delivery Cetrimonium Compounds lipids (amino acids peptides and proteins)Self-assembly 0210 nano-technology

description

The limited stability of catanionic vesicles has discouraged their wide use for encapsulation and controlled release of active substances. Their structure can easily break down to form lamellar phases, micelles or rearrange into multilamellar vesicles, as a consequence of small changes in their composition. However, despite the limited stability, catanionic vesicles possess an attractive architecture, which is able to efficiently encapsulate both hydrophobic and hydrophilic molecules. Therefore, improving the stability of the vesicles, as well as the control on unilamellar structures, are prerequisites for their wider application range. This study focuses on the impact of β-cyclodextrins for the stabilization of SDS/CTAB catanionic vesicles. Molar ratio and sample preparation procedures have been investigated to evaluate the temperature stability of catanionic vesicles. Diffusion and spectroscopic techniques evidenced that when β-cyclodextrins are added, unilamellar structures are stabilized above the multilamellar-unilamellar vesicles critical temperature. The results evidence encouraging perspectives for the use of vesicular nanoreservoirs for drug depot applications.

year	journal	country	edition	language
2018-01-01	International journal of pharmaceutics

10.1016/j.ijpharm.2018.07.026 https://pubmed.ncbi.nlm.nih.gov/29990535