Search results for "Sab"

showing 10 items of 3756 documents

Double copies of blaKPC-3::Tn4401a on an IncX3 plasmid in Klebsiella pneumoniae successful clone ST512 from Italy

2015

ABSTRACT A carbapenem-resistant sequence type 512 (ST512) Klebsiella pneumoniae carbapenemase 3 (KPC-3)-producing K. pneumoniae strain showing a novel variant plasmid content was isolated in Palermo, Italy, in 2014. ST512 is a worldwide successful clone associated with the spread of bla KPC genes located on the IncFIIk pKpQIL plasmid. In our ST512 strain, the bla KPC-3 gene was unusually located on an IncX3 plasmid, whose complete sequence was determined. Two copies of bla KPC-3 ::Tn 4401a caused by intramolecular transposition events were detected in the plasmid.

transposonsequence analysispolymerase chain reactionDrug ResistanceGene DosageSettore MED/42 - Igiene Generale E Applicatabacterial proteinbeta-Lactamaseopen reading framecarbapenemasePlasmidminocyclineplasmid DNAmeropenemPharmacology (medical)geneticscolistincefpodoximeceftazidime610 Medicine & healthCarbapenemBacterialpolymyxin Btimentingene expression regulationbacteriumKlebsiella pneumoniae carbapenemase 3 producing Klebsiella pneumoniae3. Good healthantiinfective agentmicrobial sensitivity testKlebsiella pneumoniaeItalypriority journaltigecyclineMultipleclone (Java method)cefotaxime030106 microbiologyKlebsiella pneumoniae carbapenemase 3tobramycinMicrobial Sensitivity Testsgentamicinpiperacillin plus tazobactamchemistryGene dosageArticleMicrobiology03 medical and health sciencesComplete sequenceClone CellOpen Reading FramesertapenemBacterial Proteinsmultidrug resistanceextensively drug resistant bacteriumAnti-Bacterial AgentcefepimePharmacologylevofloxacinmicrobiologycefoxitinbiochemical phenomena metabolism and nutritionbacterial infections and mycosesVirologyAnti-Bacterial Agents; Bacterial Proteins; Carbapenems; Clone Cells; Drug Resistance Multiple Bacterial; Gene Dosage; Italy; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Open Reading Frames; Plasmids; beta-Lactamases; DNA Transposable Elements; Gene Expression Regulation Bacterial; Pharmacology (medical); Pharmacology; Infectious Diseasesantibiotic sensitivityClone CellsKlebsiella InfectionsceftriaxoneCarbapenemsbacterial genetics0301 basic medicinemolecular cloningSettore MED/07 - Microbiologia E Microbiologia ClinicaKlebsiella pneumoniaeTransposition (music)Drug Resistance Multiple Bacterialpolycyclic compoundsgenetic screeningcell clonecarbapenem derivativeKlebsiella infectionunclassified drugAnti-Bacterial AgentsInfectious Diseasesbacterial genePlasmidsenzymologydoripenemBiologyminimum inhibitory concentrationbeta-Lactamasesbeta lactamaseMechanisms of ResistanceciprofloxacinAmikacin; aztreonam; carbapenemase; cefepime; cefotaxime; cefoxitin; cefpodoxime; ceftazidime; ceftriaxone; ciprofloxacin; colistin; cotrimoxazole; doripenem; doxycycline; ertapenem; gentamicin; imipenem; Klebsiella pneumoniae carbapenemase 3; levofloxacin; meropenem; minocycline; piperacillin plus tazobactam; plasmid DNA; polymyxin B; tigecycline; timentin; tobramycin; unclassified drug; antiinfective agent; bacterial protein; beta lactamase; carbapenem derivative; transposon antibiotic sensitivity; Article; bacterial gene; bacterial genetics; bacterial strain; bacterium; bacterium detection; bacterium isolation; Escherichia coli; extensively drug resistant bacterium; gene dosage; genetic screening; Italy; Klebsiella pneumoniae; Klebsiella pneumoniae carbapenemase 3 producing Klebsiella pneumoniae; minimum inhibitory concentration; molecular cloning; nonhuman; polymerase chain reaction; priority journal; sequence analysis; cell clone; chemistry; drug effects; enzymology; gene expression regulation; genetics; isolation and purification; Klebsiella infection; Klebsiella pneumoniae; metabolism; microbial sensitivity test; microbiology; multidrug resistance; open reading frame; plasmid; transposon Anti-Bacterial Agents; Bacterial Proteins; beta-Lactamases; Carbapenems; Clone Cells; DNA Transposable Elements; Drug Resistance Multiple Bacterial; Gene Dosage; Gene Expression Regulation Bacterial; Italy; Klebsiella Infections; Klebsiella pneumoniae; Microbial Sensitivity Tests; Open Reading Frames; Plasmidsplasmidbacterium isolationEscherichia coliGeneAmikacinbacterium detectionnonhumandoxycyclineisolation and purificationGene Expression Regulation Bacterialbiology.organism_classificationbacterial straincotrimoxazoleOpen reading frameDNA Transposable Elementdrug effectsDNA Transposable Elementsmetabolismaztreonamimipenem
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The prolyl-isomerase PIN1 is essential for nuclear Lamin-B structure and function and protects heterochromatin under mechanical stress.

2021

Summary: Chromatin organization plays a crucial role in tissue homeostasis. Heterochromatin relaxation and consequent unscheduled mobilization of transposable elements (TEs) are emerging as key contributors of aging and aging-related pathologies, including Alzheimer’s disease (AD) and cancer. However, the mechanisms governing heterochromatin maintenance or its relaxation in pathological conditions remain poorly understood. Here we show that PIN1, the only phosphorylation-specific cis/trans prolyl isomerase, whose loss is associated with premature aging and AD, is essential to preserve heterochromatin. We demonstrate that this PIN1 function is conserved from Drosophila to humans and prevents…

transposonsNeocortexMiceHeterochromatinProlyl isomeraseDrosophila ProteinsBiology (General)PhosphorylationRNA Small InterferingTissue homeostasisCells CulturedSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniNeuronsLamin Type BChemistryHP1phosphorylationneurodegenerationnuclear envelopePeptidylprolyl IsomeraseCell biologyDrosophila heterochromatin HP1 Lamin mechanical stress neurodegeneration nuclear envelope phosphorylation PIN1 transposonsNuclear laminaDrosophilaRNA InterferencePremature agingQH301-705.5HeterochromatinNuclear EnvelopeDrosophila; heterochromatin; HP1; Lamin; mechanical stress; neurodegeneration; nuclear envelope; phosphorylation; PIN1; transposonsSettore BIO/11 - Biologia MolecolareSettore MED/08 - Anatomia PatologicaGeneral Biochemistry Genetics and Molecular BiologyPIN1Alzheimer DiseaseSettore MED/05 - Patologia ClinicaAnimalsHumansHeterochromatin maintenancemechanical stressheterochromatinmechanical streMice Inbred C57BLNIMA-Interacting Peptidylprolyl IsomeraseChromobox Protein Homolog 5DNA Transposable ElementsHeterochromatin protein 1Stress MechanicalLaminLaminCell reports
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Riflessioni sulla responsabilità del vettore: sintesi di una giornata di studio

2004

trasporto responsabilità vettoreSettore IUS/06 - Diritto Della Navigazione
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Acceptance and Commitment Therapy Group Intervention for Parents of Children with Disabilities (Navigator ACT): An Open Feasibility Trial

2022

AbstractParents of children with autism spectrum disorder and other disabilities report high levels of distress, but systematically evaluated interventions are few. This study aimed to evaluate the feasibility of a novel, manualized Acceptance and Commitment Therapy group intervention (Navigator ACT) in a sample of 94 parents of children with disabilities. Feasibility was measured by treatment completion, credibility, and satisfaction, and preliminary outcomes by using self-rating scales administered at the baseline, post-intervention, and follow-up. The results imply the intervention is feasible in the context of Swedish outpatient habilitation services. A preliminary analysis of the outco…

treatmenthyväksymis- ja omistautumisterapiaautism spectrum disorderparental distressautismikirjon häiriötstressiparental stresshenkinen hyvinvointivammaisuusvanhemmatdisabilityryhmäterapiaDevelopmental and Educational Psychologylapset (perheenjäsenet)feasibilityJournal of Autism and Developmental Disorders
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Musculoskeletal disorders and disability among forest industry workers in lower and higher sickness absence groups: a case-control study

2019

Background: Musculoskeletal wellbeing and disorders and explanatory factors were investigated among forest industry employees. Methods: A new positive approach to maintenance of working ability focuses on being present at work. 140 individuals with low sickness absence (≤1.5% in hours during the past 6.5 years) and 140 controls with higher sickness absence (>1.5%), randomly selected from the source population (n = 636) in workplace clusters (n = 5), were studied. Questionnaire data on functioning, musculoskeletal disorders (MSD) and disability, work ability and wellbeing were collected (response rate 65%) during December 2012–January 2013. 183 employees (mean age 48.5; females 32%) particip…

työperäiset sairaudetSickness absencemetsäteollisuusrasitusvammattyöterveysbusiness.industryworking agedCase-control studyPhysical Therapy Sports Therapy and Rehabilitationsickness absence030210 environmental & occupational healthmusculoskeletal disability03 medical and health sciences0302 clinical medicineEnvironmental healthmetsätyöntekijätMedicine030212 general & internal medicinemusculoskeletal disordersmetsätyöForest industrybusinesssairauslomaEuropean Journal of Physiotherapy
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"Pasaules koru olimpiādes - 2014" tēls elektroniskajos medijos

2015

Bakalaura darba tēma ir „„Pasaules koru olimpiādes – 2014” tēls elektroniskajos medijos”. Bakalaura darba mērķis ir noskaidrot, kāds ir „Pasaules koru olimpiādes – 2014” tēls pasākuma organzētāju, dalībnieku un apmeklētāju vidū, kā arī noskaidrot, kā elektroniskie mediji Tvnet.lv, Diena.lv, NRA.lv, LSM.lv un Delfi.lv ir konstruējuši pasākuma tēlu. Pirmajā nodaļā aplūkots teorētiskais materiāls par tēlu, sabiedriskajām attiecībām, elektronisko mediju nozīmi. Aprakstīta arī Klausa Mertena tēla teorija. Otrajā nodaļā aprakstītas pētījuma izveidei izmantotās pētniecības metodes: kontentanalīze, semantiskais diferenciālis, aptauja un intervija.Trešā nodaļa sastāv no „Pasaules koru olimpiādes” ap…

tēls„Pasaules koru olimpiāde”sabiedriskās attiecībasKomunikācijas zinātnetēla veidošana
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"tavs.skrinings.lv" - digitāla platforma krūts vēža personalizēto riska faktoru atpazīšanai

2021

tīmekļa lietotneDatorzinātnevuejskrūts vēzissabiedrības veselībadjango
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Praca nad własną biografią matek dzieci z niepełnosprawnością na przykładzie projektu pt. „Siła kobiet”

2021

W artykule opisany został projekt edukacyjno-socjalny pt. ,,Siła kobiet", skierowany do matek dzieci z niepełnosprawnością. Projekt miał tez charakter naukowo-badawczy, którego nadrzędnym celem było poznanie procesu uczenia się z biografii. Intencją autorki było zaprezentowanie działań realizowanych podczas projektu, które miały umożliwić jego uczestniczkom zaobserwowanie procesu uczenia się z własnej biografii w kontekście niepełnosprawności swojego dziecka. W pierwszej części artykułu zamieszczony został teoretyczno-metodologiczny opis projektu i jego metodyczne podstawy. W części analitycznej zaprezentowane zostały fragmenty transkrypcji w odniesieniu do teorii uczenia się sytuacyjnego i…

uczenie się sytuacyjnesituated learningmother of a child with disabilityboundary situationtransformatywne uczenie sięteoria zaufania społecznegotrajectory of sufferinglearning from own biographyuczenie się z własnej biografiibiograficzne uczenie siętrajektoria cierpieniathe social trust theorytransformative learningbiographical learningsytuacje granicznematka dziecka z niepełnosprawnością
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Sexual and reproductive health and rights through the lens of belonging : Intersectional perspectives on disability, gender, and adolescence in Tanza…

2023

Tämä Tansaniaan sijoittuva väitöskirjatutkimus tarkastelee vammaisuutta kehityskysymyksenä seksuaali- ja lisääntymisterveyden ja -oikeuksien kautta. Se edistää intersektionaalista ja kontekstisidonnaista ymmärrystä vammaisuudesta, sukupuolesta ja nuoruudesta. Tutkimuksen teoreettisena inspiraationa hyödynnettiin vammaisuuden sosiaalista ja ihmisoikeusmallia. Tutkimus haastaa tiedonhankinnan kolonialiteetteja perehtymällä 199 tansanialaisen eri tavoin vammaisen tytön näkemyksiin. Tutkimuskysymyksiin etsittiin vastauksia laadullisen abduktiivisen tutkimusotteen ja osallistavan vammaistutkimuksen avulla. Vammaisten tyttöjen näkemyksiä tutkittiin eläytymismenetelmän kautta. Tutkimusjulkaisuissa…

ulemavuafya ya uzazi na hakivammaisuusdisabilitylisääntymisoikeudetseksuaaliterveysTansaniasexual healthnuoruusadolescencereproductive rightsTanzaniaujana wa rika la balehe
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Latvijas lašveidīgo zivju upju atjaunošanas projekti: ihtiofaunas izmaiņas un sabiedrības viedoklis

2022

Upes ir vienas no visapdraudētākajām, bet tajā pašā laikā bioloģiski daudzveidīgākajām ekosistēmām pasaulē, līdz ar to ir svarīgi uzlabot vai vismaz saglabāt to labu ekoloģisko stāvokli. Kā viens no pasaulē plaši izmantotajiem ekoloģiskās kvalitātes uzlabošanas instrumentiem ir upju atjaunošana. Latvijā lielākoties tiek īstenota bebru dambju un koku sanesumu izvākšana no upēm, tomēr arvien biežāk tiek īstenotas arī nārsta vietu atjaunošanas un citi lielāki pasākumi. Tikpat svarīgi, cik īstenot šādus pasākumus, ir novērtēt to efektivitāti, tomēr nereti kā vienīgais projekta sekmju novērtēšanas indikators tiek izmantots sabiedrības (tai skaitā projektā iesaistīto cilvēku) subjektīvs viedoklis…

upju atjaunošanaVides zinātneefektivitātesabiedrības viedoklisupeszivis
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