Search results for "Safety"
showing 10 items of 1959 documents
Evolution of the Regulatory Landscape for Immunomodulatory Compounds and Personalized Therapeutic Cancer Vaccines
2014
The term cancer immunotherapy covers a huge range of different therapeutic interventions based on highly diverse medicinal products. Some immunotherapy products such as monoclonal antibodies have successfully been developed during the last years and contributed to major advances in cancer therapy. Development of cancer vaccines seemed to be more challenging. Nevertheless, some promising candidates are currently in late-stage clinical development, and one product (sipuleucel-T) was recently approved in the United States (USA) and in the European Union (EU). Additionally, cell therapy approaches based on adoptive lymphocyte transfer have recently come into focus due to surprisingly efficient …
Psychosocial safety climate: Conceptual distinctiveness and effect on job demands and worker psychological health
2012
Abstract Psychosocial safety climate is an emerging construct that refers to shared perceptions regarding policies, practices, and procedures for the protection of worker psychological health and safety. The purpose of the research was to: (1) demonstrate that psychosocial safety climate is a construct distinct from related climate measures (i.e., physical safety climate, team psychological safety, and perceived organizational support); and (2) test the proposition that organizational psychosocial safety climate determines work conditions (i.e., job demands) and subsequently worker psychological health. We used samples from two different cultures; an Australian sample (N = 126 workers in 16…
Volatile Compounds in Red Wines Processed on an Industrial Scale by Short Pre-fermentative Cold Maceration
2012
Nero d’Avola and Shiraz grapes were subjected to pre-fermentative cold maceration at 4°C for about 24 h in industrial winemaking, in order to evaluate the effects of the pre-treatment on aroma profile. The volatile compounds were identified by gas chromatography-mass spectrometry and grouped into 14 chemical families 4 and 9 months after bottling. Principal components analysis (PCA) plots of the volatile compounds showed clear separation among wines from the Shiraz and Nero d’Avola varieties. For instance, Shiraz wines were characterized along the PC1 axe by esters of organic acids, norisoprenoids and C6 alcohols, while Nero d’Avola wines were characterized by acetates and monoterpenic oxid…
Economic Robustness Analysis of Adaptive Chart Schemes for Monitoring the Total Nonconformities Number in Inspection Units
2015
In recent years, a variety of enhanced schemes for the c chart have been developed aimed at the effectiveness improving of the related statistical process control (SPC) procedures. However, the performance of such chart schemes can be very sensitive to values assumed for some operating and cost parameters, in particular to the considered process shift magnitude arising from out-of-control conditions. In such a circumstance, the effectiveness of such chart schemes can be subjected to substantial reductions when they are implemented in operative contexts given that, in practice, such value is unknown and it can be very difficult to accurately estimate. For this reason, in the present paper i…
A Multi-Objective Design Approach for the c Chart Considering Taguchi Loss Function
2013
The present paper proposes a multi-objective design approach for the c chart, considering in the optimization process of the chart parameters both the statistical and the economic objectives. In particular, the minimization of the hourly total quality related costs is the considered objective to carry out the economic goal, whereas the statistical objective is reached by the minimization the out-of-control average run length of the chart. A mixed integer non-linear constrained mathematical model is formulated to solve the treated multi-objective optimization problem, whereas the Pareto optimal frontier is described by the e-constraint method. In order to show the employment of the proposed …
Comparing the Economic Effectiveness of Various Adaptive Schemes for the c Chart
2013
In an attempt to improve the effectiveness of statistical process control (SPC) procedures, a variety of adaptive schemes has been developed in the last decades. However, considering control charts for attributes, relatively few works about adaptive schemes have been proposed, and most of them were proposed only recently. The common characteristic of those schemes is that one or more chart parameters are allowed to adaptively vary during the SPC operations according to the sampling information history, typically the current point plotted on the chart. In this way, the adaptive schemes are smarter than the related static ones, but they are also more complicated in terms of implementation. Th…
An Effective Double Sampling Scheme for thecControl Chart
2013
In the present paper is developed a statistical process control inspection procedure based on a new simple-to-implement and effective double sampling scheme for the c control chart, aimed at the minimization of the number of inspected observation units and warranting fixed levels for the type I and II error risks. In particular, the formulations of the false alarm risk α, the power P of the chart, and the expected number of inspected observation units for the developed inspection procedure are given, whereas a macro of Microsoft Excel is adopted to solve the tackled problem. In order to illustrate the application of the developed approach and to investigate on the influence of several opera…
Economic Design Approach for an SPC Inspection Procedure Implementing The Adaptive C Chart
2013
The present paper proposes a design approach for a statistical process control (SPC) procedure implementing a c control chart for non-conformities, with the aim to minimize the hourly total quality-related costs. The latter take into account the costs arising from the non-conforming products while the process is in-control and out-of-control, for false alarms, for assignable cause locations and system repairs, for sampling and inspection activities and for the system downtime. The proposed economic optimization approach is constrained by the expected hourly false alarms frequency, as well as the available labor resource level. A mixed integer non-linear constrained mathematical model is dev…
A hardware skin-segmentation IP for vision based smart ADAS through an FPGA prototyping
2017
International audience; In this paper we presents a platform based design approach for fast HW/SW embedded smart Advanced Driver Assistant System (ADAS) design and prototyping. Then, we share our experience in designing and prototyping a HW/SW vision based smart embedded system as an ADAS that helps to increase the safety of car's drivers. We present a physical prototype of the vision ADAS based on a Zynq FPGA. The system detects the fatigue state of the driver by monitoring the eyes closure and generates a real-time alert. A new HW/SW codesign skin segmentation step to locate the eyes/face is proposed. Our presented new approach migrates the skin segmentation step from processing system (S…
Dovere di soccorso in mare, diritto internazionale e cause di esclusione dell’illiceità penale
2021
Due vicende giudiziarie (i casi Vos Thalassa e Rackete), entrambe oggetto di notevole attenzione mediatica, oltre che di diversi commenti da parte della dottrina penalistica, consentono di ragionare sui rapporti che intercorrono tra diritto internazionale e diritto interno nel regime giuridico del dovere di soccorso in mare. Più precisamente, la lettura di tali vicende permette di fare alcune osservazioni sul rilievo che devono avere le norme internazionali quando il giudice penale nazionale sia chiamato a pronunciarsi in merito all’applicabilità delle scriminanti a beneficio di soggetti che si oppongono a ordini dell’autorità che impediscono il completamento delle attività di soccorso