Search results for "Safety"

Phytochemical and Pharmacological Evaluation of the Residue By-Product Developed from the Ocimum americanum (Lamiaceae) Postdistillation Waste

2021

The yield of essential oils in plants is not high and postdistillation wastes rich in phenolic compounds could be used to enhance the profitability of essential oil-bearing plants. The aim of the study was to evaluate polyphenols in a dry extract obtained from the postdistillation waste of the American basil (Ocimum americanum L.) herb, and to conduct the screening of its pharmacological activities. Rosmarinic acid, caffeic acid and rutin were identified in the extract using high-performance thin-layer chromatography. The high-performance liquid chromatography analysis found the presence of a plethora of polyphenols in the extract. Rosmarinic acid, luteolin-7-O-glucoside and rutin were as t…

In the name of security : Governmentality apparatus in a multilingual mine in Arctic Finland

2021

This critical sociolinguistic study explores how mining work is governed in the name of security in a mine in Arctic Finland. Although the mining industry is dominated by multinational corporations, mines themselves tend to be concentrated in peripheries where a mobile and multilingual workforce is recruited. Mining is a high-risk business: industrial accidents and environmental damage can be severe. Discursive practices play a crucial role in risk management. In this study, the nexus of language, security, and production in mining work is analyzed by applying the Foucauldian concept of 'governmentality'. The data comprise ethnographic observations, work-related documents, and interviews co…

Beta-decay studies for applied and basic nuclear physics

2020

In this review we will present the results of recent beta-decay studies using the total absorption technique that cover topics of interest for applications, nuclear structure and astrophysics. The decays studied were selected primarily because they have a large impact on the prediction of a) the decay heat in reactors, important for the safety of present and future reactors and b) the reactor electron antineutrino spectrum, of interest for particle/nuclear physics and reactor monitoring. For these studies the total absorption technique was chosen, since it is the only method that allows one to obtain beta decay probabilities free from a systematic error called the Pandemonium effect. The me…

Ultrasound bioeffects in rats: quantification of cellular damage in the fetal liver after pulsed Doppler imaging

2011

Objective To determine whether pulsed Doppler examination of the ductus venosus in rat fetuses could damage exposed tissue. Methods On gestational day 18, the livers of a mean of approximately five fetuses per mother (n = 5.14, SD = 1.6), in a cohort of 35 pregnant female rats, were exposed individually to pulsed Doppler and these were considered the 'exposed group'. The remaining fetuses in each pregnant rat (n = 5.16, SD = 2.1) formed the 'control group'. We tested for 600, 300, 60, 20, 15, 10 and 3 s of exposure of the fetal ductus venosus and the damage was evaluated measuring a cell death index of apoptotic activity at 7 h post-exposure (n = 16). In addition, subgroups of mothers were …

Safety and potential interaction of immunosuppressive drugs for the treatment of inflammatory bowel disease in elderly patients

2021

Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are chronic diseases associated with increased morbidity and reduced quality of life. Age may represent a risk factor for adverse events, due to the multimorbidity and polypharmacy, common in elderly patients. Elderly are often not included in clinical trials evaluating efficacy and safety of study drugs for the treatment of inflammatory bowel diseases. Several drugs, such as aminosalicylates, systemic corticosteroids, immunosuppressant drugs, biological drugs and Janus Kinase inhibitors, are available for the management of inflammatory bowel diseases. With the increasing spectrum of therapeutic options, it is th…

Intravenous Contrast Material for Cardiac Computed Tomography

2023

Purpose: The Italian Registry of Contrast Material use in Cardiac Computed Tomography (iRCM-CCT) is a multicenter, multivendor, observational study on the use of contrast media (CM) in patients undergoing cardiac computed tomography (CCT). The aim of iRCM-CCT is to assess image quality and safety profile of intravenous CM compounds. Materials and methods: iRCM-CCT enrolled 1842 consecutive patients undergoing CCT (≥50 per site) at 20 cluster sites with the indication of suspected coronary artery disease. Demographic characteristics, CCT, and CM protocols, clinical indications, safety markers, radiation dose reports, qualitative (ie, poor vascular enhancement) and quantitative (ie, HU attenu…

Le norme internazionali e nazionali sulla sicurezza della navigazione, con particolare riferimento al mezzo nautico

2006

"Oppilaat ovat turvallisia, koska lapsi ei saa lyötyä niin kovaa kuin aikuinen" : viidesluokkalaisten käsityksiä turvallisuudesta

2017

Tutkimuksen teon lähtökohtana oli fenomenologinen etnografia, jossa tutkitaan yhden luokan oppilaiden omia käsityksiä turvallisuudesta. Aineistoa kerättiin opettajahaastattelulla, havainnoinnilla ja teematunnilla, jossa oppilaita pyydettiin kirjoittamaan omia käsityksiään turvallisuudesta. Tarkoituksena oli ensisijaisesti luoda etnografia ottamalla selvää, mitä lapset tarkoittavat turvallisuudella. Toissijainen tarkoitus oli vaikuttaa mahdollisimman vähän tutkimuskohteisiin. Tutkimuksella haluttiin selvittää tietyssä hetkessä lasten aito palaute, josta voisi ymmärtää, mitä lapset tarkoittavat turvallisuudella mahdollisesti toisin kuin aikuiset. Lapset hahmottelevat turvallisuutta monella ta…

Combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Hemophilus influenzae type b vaccine; Infanrix™ hexa: T…

2014

Infant vaccination using 2-dose priming at 3 and 5 mo of age with a booster at 11–12 mo of age was pioneered in Italy. The 3-5-11 schedule is now used in a growing number of European countries. Infanrix™ hexa (DTPa-HBV-IPV/Hib, GlaxoSmithKline Vaccines) was first licensed for use in 2000 and has been the only pediatric hexavalent vaccine available since 2005. We reviewed available clinical trial data describing the immunogenicity of DTPa-HBV-IPV/Hib when administered at 3, 5, and 11 mo of age, and conducted an analysis of safety using global and Italian post-marketing surveillance data. In Italy, DTPa-HBV-IPV/Hib has a demonstrated safety record extending over a decade of use, it has been a…

Why Did They Leave School? A Self Determination Theory Perspective into Narratives of Finnish Early School Leavers

2021

The present study aims to provide insights into the experiences of early school leavers within the Finnish context. We conducted a narrative inquiry among eleven early school leavers who were in prison when they were interviewed. Self Determination Theory (SDT), more specifically the concept of frustration of the three basic psychological needs of competence, relatedness and autonomy, and the tendency of people to move towards more supporting environments, was used as an interpretative tool, along with contextual information. We identified three pathways out of school, differing in the locus of need thwarting circumstances and the availability of access to transfer into a more satisfying en…