Search results for "Sage"
showing 10 items of 1373 documents
Medroxyprogesterone acetate: steady-state pharmacokinetics bioequivalence of two oral formulations
1989
Two micronized oral formulations of medroxyprogesterone acetate (MPA) (Farlutal and Clinovir) were compared in order to evaluate their relative bioavailability. Sixteen female patients with metastatic breast cancer were entered in a randomized cross-over study on 500-mg MPA tablets repeatedly administered (twice daily for 20 days). At the steady state, similar mean +/- SD serum levels of MPA were obtained (131 +/- 44 ng/ml for Farlutal and 136 +/- 45 ng/ml for Clinovir) and the two formulations proved to be bioequivalent (confidence interval at a significance level of 0.95 = 93%-107%).
X-stream CSD atbalsts Vērtspapīru uzskaites sistēmā
2015
Bakalaura darba mērķis ir novērtēt Vērtspapīru uzskaites sistēmas ziņojumu apmaiņas ar X-stream CSD sistēmas ieviešanas iespējamību, apskatīt ierobežojumus un ieviešanas prasības. Papildus nepieciešams novērtēt esošo situāciju un X-stream CSD atbalsta ieviešanas Vērtspapīru uzskaites sistēmā potenciālās priekšrocības un ieguvumus. Sekundārie bakalaura darba mērķi ir iegūt plašākas zināšanas par ISO 20022 standartu un NASDAQ OMX piedāvātā X-stream CSD risinājuma iespējām un metodēm, kuru izmantošana ļauj veikt atbalsta ieviešanu Vērtspapīru uzskaites sistēmā. Pēc darbā aprakstītās realizācijas ir jāspēj veikt X-stream CSD atbalsta ieviešanu Vērtspapīru uzskaites sistēmā.
Quantitation of antihistamines in pharmaceutical preparations by liquid chromatography with a micellar mobile phase of sodium dodecyl sulfate and pen…
2002
Abstract A reversed-phase liquid chromatographic procedure with a micellar mobile phase of sodium dodecyl sulfate (SDS), containing a small amount of pentanol, was developed for the control of 7 antihistamines of diverse action in pharmaceutical preparations (tablets, capsules, powders, solutions, and syrups): azatadine, carbinoxamine, cyclizine, cyproheptadine, diphenhydramine, doxylamine, and tripelennamine. The retention times of the drugs were <9 min with a mobile phase of 0.15M SDS–6% (v/v) pentanol. The recoveries with respect to the declared compositions were in the range of 93–110%, and the intra- and interday repeatabilities and interday reproducibility were <1.2%. Th…
New methods of delivery of amphotericin B.
1993
Fungal infections continue to be a major problem in the management of immunocompromised patients. Despite its formidable toxicity and treatment failures, amphotericin B is still the drug of choice for most of these infections. One strategy for reducing the toxicity of amphotericin B and thus permitting administration of higher doses is that of using less toxic formulations. Entrapping amphotericin B into liposomes or binding it to other substances reduces its toxicity to host cells, whereas the selective binding of amphotericin B to ergosterol preserves its toxicity to fungal cells. Adding fungus-specific antibodies to such liposomes may further increase the efficiency of drug targeting. Th…
Iron in Translation: From the Beginning to the End
2021
Iron is an essential element for all eukaryotes, since it acts as a cofactor for many enzymes involved in basic cellular functions, including translation. While the mammalian iron-regulatory protein/iron-responsive element (IRP/IRE) system arose as one of the first examples of translational regulation in higher eukaryotes, little is known about the contribution of iron itself to the different stages of eukaryotic translation. In the yeast Saccharomyces cerevisiae, iron deficiency provokes a global impairment of translation at the initiation step, which is mediated by the Gcn2-eIF2α pathway, while the post-transcriptional regulator Cth2 specifically represses the translation of a subgroup of…
Mésusage de substances psychoactives en milieu professionnel. « II-Données socio-économiques "
2013
National audience
Comparison of two portable solid state detectors with an improved collimation and alignment device for mammographic x-ray spectroscopy.
2006
We describe a portable system for mammographic x-ray spectroscopy, based on a 2 X 2 X 1 mm3 cadmium telluride (CdTe) solid state detector, that is greatly improved over a similar system based on a 3 X 3 X 2 mm3 cadmium zinc telluride (CZT) solid state detector evaluated in an earlier work. The CdTe system utilized new pinhole collimators and an alignment device that facilitated measurement of mammographic x-ray spectra. Mammographic x-ray spectra acquired by each system were comparable. Half value layer measurements obtained using an ion chamber agreed closely with those derived from the x-ray spectra measured by either detector. The faster electronics and other features of the CdTe detecto…
Reliability of mitochondrial DNA in an acanthocephalan: The problem of pseudogenes
2006
The utility of mitochondrial DNA as a molecular marker for evolutionary studies is well recognized. However, several problems can arise when using mitochondrial DNA, one of which is the presence of nuclear mitochondrial pseudogenes, or Numts. Pseudogenes of cytochrome oxidase I were preferentially amplified from Acanthocephalus lucii (Acanthocephala) using a universal PCR approach. To verify the presence and abundance of pseudogenes, length heterogeneity analysis of the PCR fragments was performed. PCR products obtained with universal primers often contained fragments of different sizes. Cloned sequences from universal PCR products nearly always contained sequence abnormalities such as inde…
The epistemological structure of mobilities
2021
Purpose This paper aims to revolve around two problems which, though imagined as different, can be addressed altogether. On one hand, the advance of terrorism as a major threat to the tourism industry, while – on the other – we discuss the ontological nature of tourism as a rite of passage, which is vital to keep the political legitimacy of officialdom. At the time, paradoxically, social scientists shrug off tourism as a naïve commercial activity, while the main tourist destinations are being attacked by jihadism. This suggests the disinterest of ones associates to the interests of others. Design/methodology/approach The author holds the thesis that tourism derives from ancient institution…
Mobilās saskarnes izveide Sage noliktavas uzskaites sistēmai
2021
Kvalifikācijas darba mērķis ir izstrādāt android mobilo lietotni, kura, darbiniekam, atvieglos noliktavas procesu datu ievadi uzņēmuma vadības sistēmā Sage.