Search results for "ScIM"
showing 10 items of 263 documents
Functional evidence for GABA as modulator of the contractility of the longitudinal muscle in mouse duodenum: Role of GABAA and GABAC receptors
2007
We investigated, in vitro, the effects of gamma-aminobutyric acid (GABA) on the spontaneous mechanical activity of the longitudinal smooth muscle in mouse duodenum. GABA induced an excitatory effect, consisting in an increase in the basal tone, which was antagonized by the GABA(A)-receptor antagonist, bicuculline, potentiated by (1,2,5,6-Tetrahydropyridin-4-yl)methylphosphinic acid hydrate (TPMPA), a GABA(C)-receptor antagonist and it was not affected by phaclofen, a GABA(B)-receptor antagonist. Muscimol, GABA(A) receptor agonist, induced a contractile effect markedly reduced by bicuculline, tetrodotoxin (TTX), hexamethonium and atropine. Cis-4-aminocrotonic acid (CACA), a specific GABA(C) …
GABA-A receptoru agonista muscimola ietekme uz acetilholīna daudzumu Alcheimera slimības tipa modeļdzīvnieku smadzenēs
2017
Šī darba mērķis bija noskaidrot muscimola ļoti zemu devu (0,01 un 0,05 mg/kg) efektus uz acetilholīna šķelšanu intracerebroventrikulāras (i.c.v.) streptozocīna (STZ) ievadīšanas AD-tipa modelī. Rezultāti rāda, ka: 1.STZ i.c.v. ievadīšana izraisīja būtisku garozas un hipokampa AChE blīvuma palielinājumu. 2.Muscimols 0,01 un 0,05 mg/kg devās normalizēja AChE blīvumu STZ grupas žurku garozā un hipokampā līdz kontroles grupas līmenim. Iegūtie dati ļauj secināt, ka muscimola ļoti mazas devas regulē acetilholīna daudzumu i.c.v. STZ modelī. Iespējams, šis regulācijas mehānisms atbild par iepriekš novērotiem telpiskās atmiņas uzlabojumiem AD-tipa modeļdzīvniekos, tomēr ir nepieciešami tālāki pētīju…
GABAA agonista muscimola ietekme uz žurku atmiņu alcheimera slimības tipa modelī
2015
Darba mērķis bija noskaidrot GABAA agonista muscimola mazo devu ietekmi uz žurku atmiņu icv STZ AD tipa modelī. Lai noteiktu žurku iemācīšanos un atmiņu, tika veikti ūdens labirinta treniņtesti un fināla tests. Rezultāti rāda, ka icv STZ ievade žurkām izraisīja telpiskās atmiņas traucējumus. Muscimols abās devās (0,01 un 0,05 mg/kg) aizsargāja žurkas no STZ izraisītiem efektiem ūdens labirinta testā, uzlabojot to telpisko atmiņu, iemācīšanos un lokomotoro aktivitāti. Iegūtie dati ļauj secināt, ka muscimola mazo devu potenciāls ir intriģējošs jauno anti-AD terapiju izpētē un, ka būtu nepieciešama muscimola hronisko efektu izpēte minētajā modelī.
Age-related differences of γ-aminobutyric acid (GABA)ergic transmission in human colonic smooth muscle.
2021
Background: Enteric neurons undergo to functional changes during aging. We investigated the possible age-associated differences in enteric γ-aminobutyric acid (GABA)ergic transmission evaluating function and distribution of GABAergic receptors in human colon. Methods: Mechanical responses to GABA and GABA receptor agonists on slow phasic contractions were examined in vitro as changes in isometric tension in colonic muscle strips from young (<65 years old) and aged patients (>65 years old). GABAergic receptor expression was assessed by quantitative RT-PCR. Key Results: In both preparations GABA induced an excitatory effect, consisting in an increase in the basal tone, antagonized by th…
Assembly of functional α6β3γ2δ GABAA receptors in vitro
2000
Transgenic mice deficient in the alpha6 subunit of the GABA(A) receptor show reduced levels of the delta subunit protein and an altered GABA(A) receptor pharmacology, suggesting selective assembly mechanisms. Delta reduced the binding of [3H]Ro15-4513 or t-butylbicyclophosphoro[35S]thionate and, to a lesser extent, [3H]muscimol to recombinant alpha1beta1gamma2(delta), alpha4beta1gamma2(delta) and alpha6beta1gamma2(delta) receptors, paralleled by diminished GABA-evoked maximal currents in electrophysiological recordings for the latter one. The delta subunit gave rise to a lower EC50 for GABA and a slowed desensitization indicating its assembly in alpha6beta2delta, alpha6beta1gamma2delta and …
Antonello Gagini "architetto" 1478-1536
2010
L'attività architettonica di Antonello Gagini, celebre scultore del primo Cinquecento, rappresenta ancora oggi un problema storiografico, fondamentale per la comprensione del rinascimento siciliano. Il testo riesamina le prove di un coinvolgimento in qualità di architetto durante l'arco di attività documentata e soprattutto in opere come la grande tribuna della catte¬drale e la chiesa di Santa Maria di Portosalvo a Palermo. Il lavoro e i risultati ot¬tenuti dal maestro vengono relazionati alla sua formazione e prassi operativa, alle consuetudini del tempo, a modalità progettuali e usanze costruttive in vigore nella Sicilia fra tardogotico e rinascimento. Emergono una vicenda professionale e…
Estrategia de posicionamiento en bases internacionales de las revistas de psicología editadas y coeditadas por el Colegio Oficial de Psicólogos de Ma…
2020
The Latin American journals of psychology indexed in the Journal of Citation Reports (JCR), are generally edited by professional associations of psychologists, universities and private foundations. This paper analyzes the positioning strategy adopted by the Professional Association of Psychologists of Madrid, regarding the psychological journals in the area in which they edit. The methodological approach taken to explore the topic uses socio-bibliometric techniques gathering numerical data, and then using that data to perform analyses for a well-informed description of what the topic might be. The results reveal that journals, whose editor or co-editor was Professional Association of Psycho…
«Donna dottissima […] e d’ingegno acutissimo»: per una biografia di Margherita Sarrocchi
2023
Il saggio ricostruisce la vita di Margherita Sarrocchi, autrice del poema "La Scandebeide" (1606, 1623, 1703), amica del matematico Luca Valerio e corrispondente di Galileo Galilei. La sua figura di donna e di poetessa gode ancora oggi di grande interesse per gli studi di genere. Rilevante è la sua opera anche eprché si inscrive in un genere, quello della lirica cavalleresca, tradizionalmente riservato all'ambito maschile
CONCETTI E TERMINI IN GIOVANNI DELLA CASA CRITICO E "RETORE"
2008
Saggio su Giovanni Della Casa
Giovanni Paternò Arcivescovo di Palermo (1489-1511): un committente tra gotico e rinascimento
2022
Membro di una famiglia aristocratica siciliana e appartenente all’ordine benedettino, Giovanni Paternò ottenne la nomina ad arcivescovo di Palermo nel luglio del 1489, dopo una lunga permanenza alla guida della diocesi maltese. “Dottissimo” secondo il canonico Antonino Mongitore, che ne offre un sintetico profilo biografico, si interessò anche di questioni architettoniche, mostrando preferenze che spaziano dalle soluzioni più aggiornate del tardogotico mediterraneo e del mondo della costruzione in pietra da taglio, al linguaggio all’antica veicolato dagli scultori del marmo bianco (marmorari). Il contributo mette a fuoco la figura di questo committente e il contesto culturale nel quale si s…