Search results for "Scaffold"

Micro-architecture of three-dimensional porous scaffolds evaluated via image processing technique

2011

Polysaccharide hydrogels for regenerative medicine applications

2022

Scaffolding self-regulated learning from causal-relations texts: Diagramming and self-assessment to improve metacomprehension accuracy?

2023

AbstractThe accuracy of students’ relative comprehension judgments when reading texts is typically rather low. This has been ascribed to students grounding their comprehension judgments on cues that are not diagnostic of their actual comprehension level. Asking students to complete causal diagrams—a diagramming scaffold—before judging comprehension has proved effective in providing them with more diagnostic cues and thereby fostered metacomprehension accuracy and self-regulated learning. However, there is still room for improvement. We investigated experimentally whether adding the instruction to students to self-assess their causal diagrams: (1) would lead to more accurate judgments than c…

Ohjaava opetuskeskustelu suomalaisella viittomakielellä : tapaustutkimus kuuron oppilaan matematiikan opetuksesta

2014

Suomalaisen viittomakielen pro gradu –työssäni tarkastelen kuuron oppilaan viittomakielistä opetusta vuorovaikutuksen näkökulmasta. Tutkimusaineisto koostuu kahdesta matematiikan yksilöopetustunnista. Tutkimuksen tavoitteena on ollut selvittää, millaisia muotoja ohjaava opetuskeskustelu saa kuuron oppilaan suomalaisella viittomakielellä toteutetussa opetuksessa. Tapaustutkimuksen kautta yksilöidään ja luokitellaan myös viittomakielisen ohjaavan opetuskeskustelun osatekijöitä. Tutkimusaineiston analyysi perustuu Vygotskyn (1978) sosiokulttuuriseen teoriaan ja siihen liittyviin käsitteisiin oppimisen oikea-aikainen tukeminen ja lähikehityksen vyöhyke. Videotaltiointien analy…

Pre-service teachers and guided inquiry-based science teaching with simulations

2017

The aim of this dissertation was explore the beliefs and practices of pre-service primary teachers on using simulations as a part of guided inquiry-based lessons. Even though research has shown that using simulations to learn science offers certain learning benefits compared to other forms of instruction, their use in Finnish schools is still rare compared to the international average. Teacher training has the potential to promote the use of simulations in primary classrooms. Internationally, research has been called for the role of teachers in learning and teaching with simulations. As a part of this dissertation, an intervention was designed to accustom a group of pre-service teachers to …

Discovery of Retinoic Acid-Related Orphan Receptor γt Inverse Agonists via Docking and Negative Image-Based Screening

2018

Retinoic acid-related orphan receptor γt (RORγt) has a vital role in the differentiation of T-helper 17 (TH17) cells. Potent and specific RORγt inverse agonists are sought for treating TH17-related diseases such as psoriasis, rheumatoid arthritis, and type 1 diabetes. Here, the aim was to discover novel RORγt ligands using both standard molecular docking and negative image-based screening. Interestingly, both of these in silico techniques put forward mostly the same compounds for experimental testing. In total, 11 of the 34 molecules purchased for testing were verified as RORγt inverse agonists, thus making the effective hit rate 32%. The pIC50 values for the compounds varied from 4.9 (11 μ…

Technique des membranes induites en chirurgie maxillo-faciale

2012

Maxillofacial defects reconstruction represents a formidable challenge to achieve both functional and aesthetic goals. To succeed, numerous parameters must be taken into account: patient's general conditions, defect's location, width and type of the defect and eventual donor sites which can provide the tissues. Routine reconstructions include bone transplantation (autologous, homologous or heterologous), implantation of biomaterials and osteogenic distraction. The advantages of these techniques are evident, but they are usually limited by their complexity in patients with bad general health. The technique of induced membranes needs to be more known in maxillofacial surgery.

BMP-2 and bFGF release and in vitro effect on human osteoblasts after adsorption to bone grafts and biomaterials.

2012

Objectives Combination of scaffolds and growth factors is a promising option for several clinical problems in bone biomaterials. Simplified growth factor loading by adsorption from aqueous solution is one important option for this technology. We evaluated the adsorption followed by PBS rinsing, release and biological effect of transient loading with basic fibroblast growth factor (bFGF) and bone morphogenic protein 2 (BMP-2) on fresh frozen bone, processed bone matrix, collagen, and a ceramic material with immunofluorescence, enzyme-linked immunosorbent assay (ELISA), and qRT-PCR. Materials and methods The study consisted of three in vitro experiments (immunofluorescence, ELISA, and qRT-PCR…

TCT-441 Optical Coherence Tomography assessment of the implantation of Everolimus-Eluting Bioresorbable Scaffolds against angiographic assessment: th…

2016

Bioresorbable Vascular Scaffolds (BVS) are the newest generation of stents for use during Percutaneous Coronary Intervention. However, as history has demonstrated, each development in stent technology has been associated with its own specific complications. With BVS, there are reports that recoil is

Neo-nervegenesis in 3D dynamic responsive implant for inguinal hernia repair. Qualitative study.

2020

Abstract Background Prosthetic repair of inguinal hernias is one of the most performed surgical procedures. Nevertheless, high rates of complications affect the surgical treatment. Implant fixation, poor-quality tissue ingrowth and mesh shrinkage seem to be involved in postoperative complications, discomfort and chronic pain following inguinal hernia repair. To address these issues a multilamellar shaped 3D dynamic responsive prosthesis has been developed. This new implant, positioned fixation-free to obliterate the hernia opening, thanks its inherent dynamic compliance during inguinal movements, has demonstrated to induce an enhanced biological response. The ingrowth of newly formed muscle…