Search results for "Sclareolide"

showing 2 items of 2 documents

Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

2010

Labdadienedial and a series of C15,C16-functionalized derivatives were synthesized from commercial (+)-sclareolide and evaluated for their cytotoxic, antimycotic, and antiviral activities. Their precursors were similarly evaluated.

Antifungal AgentsStereochemistryAntineoplastic AgentsHerpesvirus 1 HumanAntiviral AgentsChemical synthesisInhibitory Concentration 50chemistry.chemical_compoundChlorocebus aethiopsDrug Discoveryotorhinolaryngologic diseasesAnimalsHumansCytotoxicityVero CellsPharmacologyOrganic ChemistryFungifood and beveragesSclareolideBiological activityGeneral MedicineCombinatorial chemistryTerpenoidIn vitrostomatognathic diseaseschemistrylipids (amino acids peptides and proteins)DiterpenesDiterpeneEnantiomerHeLa CellsEuropean Journal of Medicinal Chemistry
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Synthesis of β-methylfurolabdanes from (+)-sclareolide

2002

An efficient synthesis of the methylfurolabdane 3 from (+)-sclareolide (6) via the hydroxyalkenes 12 is reported. Alternative modes of cyclization of 12 allowed the synthesis of methyldihydrofuran derivatives 4 and 5 and methyltetrahydrofuran derivatives 15. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002)

Terpenechemistry.chemical_compoundChemistryOrganic ChemistrySclareolidePhysical and Theoretical ChemistryCombinatorial chemistry
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