6533b821fe1ef96bd127c44a

RESEARCH PRODUCT

Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

Liliana Betancur-galvisJuan Mancebo-aracilLee Solbay Agudelo-gómezVerónica Tangarife-castañoAna Cecilia Mesa-arangoBibiana ZapataMiguel A. González

subject

Antifungal AgentsStereochemistryAntineoplastic AgentsHerpesvirus 1 HumanAntiviral AgentsChemical synthesisInhibitory Concentration 50chemistry.chemical_compoundChlorocebus aethiopsDrug Discoveryotorhinolaryngologic diseasesAnimalsHumansCytotoxicityVero CellsPharmacologyOrganic ChemistryFungifood and beveragesSclareolideBiological activityGeneral MedicineCombinatorial chemistryTerpenoidIn vitrostomatognathic diseaseschemistrylipids (amino acids peptides and proteins)DiterpenesDiterpeneEnantiomerHeLa Cells

description

Labdadienedial and a series of C15,C16-functionalized derivatives were synthesized from commercial (+)-sclareolide and evaluated for their cytotoxic, antimycotic, and antiviral activities. Their precursors were similarly evaluated.

yearjournalcountryeditionlanguage
2010-04-14European Journal of Medicinal Chemistry
https://doi.org/10.1016/j.ejmech.2010.06.029