0000000000470593

AUTHOR

Bibiana Zapata

showing 4 related works from this author

Synthesis and Biological Evaluation of Combretastatin A-4 and Three Combretastatin-Based Hybrids

2012

The syntheses of combretastatin A-4 from gallic acid and of three combretastatin-based hybrids are described. Starting from commercial gallic acid, the phosphonium salt (3,4,5-trimethoxybenzylphosphonium bromide) is synthesized and coupled, through a Wittig reaction, with several aldehydes, including methoxymethyl-protected isovanillin, the aldehyde γ-bicyclohomofarnesal having a labdane skeleton, 3-(3-pyridyl) propanal, and furfural. The biological properties of the cis-coupled compounds as cytotoxic, antiviral and antifungal agents are also reported. In addition, pyrogallol, gallic and 3,4,5-trimethoxybenzoic acids have been studied biologically.

PharmacologyCombretastatin A-4CombretastatinPhosphonium saltPlant ScienceGeneral MedicineIsovanillinLabdanechemistry.chemical_compoundComplementary and alternative medicinechemistryPyrogallolDrug DiscoveryWittig reactionOrganic chemistryGallic acidNatural Product Communications
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Synthesis and biological evaluation of (+)-labdadienedial, derivatives and precursors from (+)-sclareolide

2010

Labdadienedial and a series of C15,C16-functionalized derivatives were synthesized from commercial (+)-sclareolide and evaluated for their cytotoxic, antimycotic, and antiviral activities. Their precursors were similarly evaluated.

Antifungal AgentsStereochemistryAntineoplastic AgentsHerpesvirus 1 HumanAntiviral AgentsChemical synthesisInhibitory Concentration 50chemistry.chemical_compoundChlorocebus aethiopsDrug Discoveryotorhinolaryngologic diseasesAnimalsHumansCytotoxicityVero CellsPharmacologyOrganic ChemistryFungifood and beveragesSclareolideBiological activityGeneral MedicineCombinatorial chemistryTerpenoidIn vitrostomatognathic diseaseschemistrylipids (amino acids peptides and proteins)DiterpenesDiterpeneEnantiomerHeLa CellsEuropean Journal of Medicinal Chemistry
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Synthesis and biological evaluation of dehydroabietic acid derivatives.

2010

A series of C18-oxygenated derivatives of dehydroabietic acid were synthesized from commercial abietic acid and evaluated for their cytotoxic, antimycotic, and antiviral activities.

KetoneAntifungal AgentsCarboxylic acidAntineoplastic AgentsHerpesvirus 1 HumanMicrobial Sensitivity TestsAldehydeChemical synthesisAntiviral Agentschemistry.chemical_compoundInhibitory Concentration 50Cell Line TumorDrug DiscoveryOrganic chemistryAnimalsHumansAbietic acidCytotoxicityPharmacologychemistry.chemical_classificationOrganic ChemistryFungifood and beveragesGeneral Medicineequipment and suppliesTerpenoidchemistryAbietaneslipids (amino acids peptides and proteins)DiterpeneHydrophobic and Hydrophilic InteractionsEuropean journal of medicinal chemistry
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Cytotoxic, immunomodulatory, antimycotic, and antiviral activities of semisynthetic 14-hydroxyabietane derivatives and triptoquinone C-4 epimers

2013

A series of C14-hydroxy derivatives of dehydroabietic acid were synthesised from commercial abietic acid and evaluated for their cytotoxic, antimycotic, and antiviral activities. From these C14-hydroxy derivatives, triptoquinone C-4 epimers were obtained and their immunomodulatory activity was additionally evaluated. None of the tested compounds showed antiviral activity against herpes simplex virus type 1 (HHV-1), and nor did they display antimycotic activity against certain Aspergillus, spp. except for one compound, abieta-8,11,13-trien-14,18-diol. Interestingly, two triptoquinone epimers showed cytotoxic activity, and one of them induced mitochondrial potential loss, DNA damage and cell …

PharmacologyDNA damagemedicine.medical_treatmentMonocyteOrganic ChemistryPharmaceutical ScienceBiologyCell cyclemedicine.disease_causeBiochemistryPeripheral blood mononuclear cellJurkat cellsHerpes simplex virusCytokinemedicine.anatomical_structureBiochemistryDrug DiscoverymedicineMolecular MedicineCytotoxic T cellMedChemComm
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