Search results for "Screen"
showing 10 items of 1374 documents
Genetics and"democracy".
2022
Abstract Background The spread of knowledge on the important implications of a diagnosis of genetic disease does not correspond to a sharing of the knowledge and equal rights of children. Main body It is estimated that about 5% of newborns may have a rare disease that in some cases, if diagnosed early, could have specific treatments that may be able to modify the natural history of the disease. However, in most countries the diagnosis during the first hours of life is limited to a few diseases, due to the high costs and time required for genetic investigations with classical methods. Recently, experimental projects to subject all newborns to a complete DNA analysis, with Next Generation Seq…
Cloning and characterization of a cDNA coding forCandida albicanspolyubiquitin
1996
Immunoscreening of a Candida albicans cDNA library in the expression vector lambda gt11 with rabbit polyclonal antibodies against the 37 kDa cell surface laminin receptor of C albicans resulted in the isolation of a cDNA clone of 0.9 kb. Sequencing of this clone demonstrated a full length open reading frame encoding the polyubiquitin, which contains three tandem copies, head-to-tail spacerless repeats, of the 228 nucleotides coding for the 76 amino acids of the ubiquitin protein, which is identical to that of Saccharomyces cerevisiae. The third copy possesses an extra C-terminal amino acid which is distinct to that found in S. cerevisiae. Northern blot analysis revealed a single mRNA popula…
Dual Extrapolation for Sparse Generalized Linear Models
2020
International audience; Generalized Linear Models (GLM) form a wide class of regression and classification models, where prediction is a function of a linear combination of the input variables. For statistical inference in high dimension, sparsity inducing regularizations have proven to be useful while offering statistical guarantees. However, solving the resulting optimization problems can be challenging: even for popular iterative algorithms such as coordinate descent, one needs to loop over a large number of variables. To mitigate this, techniques known as screening rules and working sets diminish the size of the optimization problem at hand, either by progressively removing variables, o…
Metastable memristive lines for signal transmission and information processing applications
2016
Traditional studies of memristive devices have mainly focused on their applications in nonvolatile information storage and information processing. Here, we demonstrate that the third fundamental component of information technologies-the transfer of information-can also be employed with memristive devices. For this purpose, we introduce a metastable memristive circuit. Combining metastable memristive circuits into a line, one obtains an architecture capable of transferring a signal edge from one space location to another. We emphasize that the suggested metastable memristive lines employ only resistive circuit components. Moreover, their networks (for example, Y-connected lines) have an info…
Age and sex-based differences in functional strength of adults participating in Special Olympics
2022
Muscular strength is a critical component of physical health. The aim of this cross-sectional study was to examine age- and sex-based differences in functional strength and rates of referral for education in a large international sample of Special Olympics athletes. A total of 30,358 (male = 19,661) adult (20–69 years old) athlete functional strength records were utilized from the Special Olympics Healthy Athletes database. Descriptive statistics were computed for the following tests: timed sit to stand, partial sit-up, grip strength, and seated push-up. Analyses of variance with Fisher-Hayter pairwise comparisons generally supported age-related decreases in strength among both males and fe…
I tumori della mammella e/o dell’ovaio di tipo eredofamiliare: strategie di prevenzione nelle donne ad alto rischio
2009
Numerosi fattori sono stati coinvolti nell’insorgenza del carcinoma mammario e dell’ovaio tra cui l’età, fattori ormonali e riproduttivi come l’età e il numero di gravidanze e l’utilizzo di contraccettivi orali e, in minor misura, fattori ambientali e stili di vita. Le possibilità per la gestione clinica delle pazienti considerate ad alto rischio di sviluppare carcinoma della mammella e/o dell’ovaio includono chirurgia profilattica (es. mastectomia bilaterale profilattica o ovarosalpingectomia bilaterale), chemioprevenzione (principalmente tamoxifene e raloxifene ma anche, più recentemente, inibitori dell’aromatasi nelle donne ad alto rischio in postmenopausa), cambiamenti nelle abitudini d…
A systematic review of handheld tools in lieu of colposcopy for cervical neoplasia and female genital schistosomiasis
2020
Abstract Background Visualization of the lesions in the lower genital tract is the mainstay for diagnosis of the four lesions found in female genital schistosomiasis (FGS), but colposcopes are generally not available in low‐resource settings. Objective We sought to review handheld devices that could potentially be used for FGS diagnosis. Search strategy We searched Medline and Embase 2015–2019 for handheld devices used in cervical cancer screening and FGS diagnosis. Selection criteria We excluded studies that did not compare the device to standard‐of‐care colposcopes or histopathology. Main results and conclusion In 11 studies, four handheld colposcopes, two smartphones, and one compact dig…
Peripheral circulating cells with paroxysmal nocturnal haemoglobinuria phenotype after a first episode of cerebral sinus vein thrombosis: Results fro…
2019
Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, potentially fatal disorder of haematopoietic stem cells caused by mutations in an X-linked gene called phosphatidylinositol glycan class A, characterised by intravascular haemolysis, bone marrow failure and thrombotic events. The disease can occur at any age, although preferentially it affects young adults; its estimated prevalence is about 1/500,000 [1]. Clinical symptoms are variable and can include haemolytic anaemia, moderate to severe impairment of haematopoiesis and, in approximately 40% of patients, thrombosis of the vessels of the abdomen, brain and skin [2]. Rare, atypical site thrombosis of the splanchnic veins or cerebral sinu…
Residual Vein Thrombosis Improves Screening for Occult Cancer: Results On 537 Patients with Idiopathic Deep Vein Thrombosis
2009
Abstract Abstract 3999 Poster Board III-935 Background Clinical advantage of extensive screening for occult cancer in patients with idiopathic Deep Vein Thrombosis (DVT) is unknown. We have demonstrated that the Residual Vein Thrombosis (RVT)-based screening for occult cancer improves early detection as well as cancer-related mortality (Siragusa S et al. Blood 2007;110(699):OC). Here we report on final analysis of 537 patients over a period of 8 years. Objective of the study We conducted a prospective study evaluating whether a RVT-based screening for cancer is sensitive and influences cancer-related mortality. Study design Prospective with two cohorts of DVT patients: the first cohort was …
Redzes asuma attālinātās pārbaudes iespēju novērtēšana
2021
Bakalaura darbs ir uzrakstīts angļu valodā uz 25 lapaspusēm. Tas satur 19 attēlus, 1 tabulu un 34 atsauces uz literatūras avotiem. Attālinātās pārbaudes rīkiem šodien nav nekādu vadlīniju vai regulējumu. Tāpēc ir nepieciešams nepārtraukti novērtēt šos rīkus. Šī pētījuma mērķis bija novērtēt redzes asuma skrīninga rīku pielietošanu attālināti. Pētījumā piedalījās 45 dalībnieki (vidējais vecums 31±5,3 gadi). Izmantojot FrACT10, redzes asums tika mērīts un analizēts divos dažādos attālinātās pārbaudes apstākļos: (1) ar optometrista palīdzību, (2) ar instrukcijas palīdzību. Rezultāti parādīja būtisku vidējā redzes asuma atšķirību starp abām grupām (p < 0,05). Tika veikta arī kvalitatīva aptauja…