Search results for "Secondary"

The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI s…

2021

Premorbid functioning and cognitive measures may reflect gradients of developmental impairment across diagnostic categories in psychosis. In this study, we sought to examine the associations of current cognition and premorbid adjustment with symptom dimensions in a large first episode psychosis (FEP) sample. We used data from the international EU-GEI study. Bifactor modelling of the Operational Criteria in Studies of Psychotic Illness (OPCRIT) ratings provided general and specific symptom dimension scores. Premorbid Adjustment Scale estimated premorbid social (PSF) and academic adjustment (PAF), and WAIS-brief version measured IQ. A MANCOVA model examined the relationship between symptom di…

“How Real People Really Need Mathematics in the Real World”—Authenticity in Mathematics Education

2018

This paper discusses authenticity from the perspective of mathematics education. Often, school mathematics offers students inauthentic word problems, which don’t show the authentic usefulness of mathematics in real life. In some tasks, authentic aspects are combined with inauthentic ones (e.g., an authentic context, but the question is artificial and different from what people within that context would ask). Several studies show that students are more motivated by authentic questions than by authentic contexts. Embedding these findings, I discuss issues associated with defining authenticity in education. A first issue is that philosophers use the term to characterize a person’s existential …

Journal of Economics and Management Research, N 10

2021

Evidenz für eine frühzeitige Therapie der COPD mit Tiotropium

2012

Hintergrund: Die Wirksamkeit von Tiotropium versus Kontrolle wurde in einer praspezifizierten Subgruppenanalyse der 4-Jahres-Studie „Understanding Potential Long-term Impacts on Function with Tiotropium“ bei Patienten mit chronisch obstruktiver Lungenerkrankung (COPD) mittleren Schweregrades (GOLD II) untersucht und erstmals den gepoolten Ergebnissen aus den schwereren Krankheitsstadien (GOLD III/IV) gegenubergestellt. Methode: Randomisierte multizentrische, doppelblinde, kontrollierte Studie mit parallelem Gruppenvergleich bei 5993 Patienten uber 4 Jahre. Die Patienten erhielten entweder Tiotropium 18 µg einmal taglich oder Plazebo. Als Endpunkte wurden der jahrliche FEV1-Abfall und weiter…

Stratification of eosinophilic asthma patients treated with reslizumab and GINA Step 4 or 5 therapy

2017

Reslizumab, an anti-interleukin-5 monoclonal antibody, significantly reduces exacerbation frequency and improves lung function, asthma control and quality of life in adults with severe eosinophilic asthma, as demonstrated in Phase III studies. This secondary analysis assessed reslizumab's efficacy in patients receiving baseline treatment per Global Initiative for Asthma (GINA) Step 4 and Step 5 guidelines. Pooled data from duplicate, Phase III, reslizumab versus placebo studies in patients with severe eosinophilic asthma (blood eosinophils ≥400 cells·µL−1) were stratified by baseline therapy. Efficacy assessments were exacerbation rates and changes from baseline forced expiratory volume in …

Sub-Finsler Horofunction Boundaries of the Heisenberg Group

2020

We give a complete analytic and geometric description of the horofunction boundary for polygonal sub-Finsler metrics---that is, those that arise as asymptotic cones of word metrics---on the Heisenberg group. We develop theory for the more general case of horofunction boundaries in homogeneous groups by connecting horofunctions to Pansu derivatives of the distance function.

Hardy inequalities and Assouad dimensions

2017

We establish both sufficient and necessary conditions for weighted Hardy inequalities in metric spaces in terms of Assouad (co)dimensions. Our sufficient conditions in the case where the complement is thin are new even in Euclidean spaces, while in the case of a thick complement we give new formulations for previously known sufficient conditions which reveal a natural duality between these two cases. Our necessary conditions are rather straight-forward generalizations from the unweighted case, but together with some examples they indicate the essential sharpness of our results. In addition, we consider the mixed case where the complement may contain both thick and thin parts.

Quantifier Elimination and Rectilinearisation Theorem for Generalised Quasianalytic Algebras

2013

International audience; An algebra of germs of real functions is generalised quasianalytic if to each element of the algebra we can associate, injectively, a power series with nonnegative real exponents. We prove a quantifier elimination and a rectilinearisation result for generalised quasianalytic algebras.

Small $C^1$ actions of semidirect products on compact manifolds

2020

Let $T$ be a compact fibered $3$--manifold, presented as a mapping torus of a compact, orientable surface $S$ with monodromy $\psi$, and let $M$ be a compact Riemannian manifold. Our main result is that if the induced action $\psi^*$ on $H^1(S,\mathbb{R})$ has no eigenvalues on the unit circle, then there exists a neighborhood $\mathcal U$ of the trivial action in the space of $C^1$ actions of $\pi_1(T)$ on $M$ such that any action in $\mathcal{U}$ is abelian. We will prove that the same result holds in the generality of an infinite cyclic extension of an arbitrary finitely generated group $H$, provided that the conjugation action of the cyclic group on $H^1(H,\mathbb{R})\neq 0$ has no eige…

Existence and almost uniqueness for p -harmonic Green functions on bounded domains in metric spaces

2020

We study ($p$-harmonic) singular functions, defined by means of upper gradients, in bounded domains in metric measure spaces. It is shown that singular functions exist if and only if the complement of the domain has positive capacity, and that they satisfy very precise capacitary identities for superlevel sets. Suitably normalized singular functions are called Green functions. Uniqueness of Green functions is largely an open problem beyond unweighted $\mathbf{R}^n$, but we show that all Green functions (in a given domain and with the same singularity) are comparable. As a consequence, for $p$-harmonic functions with a given pole we obtain a similar comparison result near the pole. Various c…