Search results for "Secondary"
showing 10 items of 1765 documents
Two Latent and Two Hyperstable Polymeric Forms of Human Neuroserpin
2010
AbstractHuman neuroserpin (hNS) is a serine protease inhibitor that belongs to the serpin superfamily and is expressed in nervous tissues. The serpin fold is generally characterized by a long exposed loop, termed the reactive center loop, that acts as bait for the target protease. Intramolecular insertion of the reactive center loop into the main serpin β-sheet leads to the serpin latent form. As with other known serpins, hNS pathological mutants have been shown to accumulate as polymers composed of quasi-native protein molecules. Although hNS polymerization has been intensely studied, a general agreement about serpin polymer organization is still lacking. Here we report a biophysical chara…
Isolation and characterization of haemoporin, an abundant haemolymph protein from Aplysia californica.
2003
In the present study, we show the isolation and characterization of the protein haemoporin, which constitutes the second most abundant protein fraction in the haemolymph of the marine gastropod Aplysia californica. Although Aplysia is commonly used to investigate the molecular basis of learning, not much is known about the proteins in its haemolymph, which is in contact with the neurons owing to the open circulatory system of molluscs. In the native state, haemoporin is a macromolecular complex forming a cylinder with a central solvent-filled pore. The native complex most probably is a homopentamer made up from 70 kDa subunits with a molecular mass of 360 kDa and a sedimentation coefficient…
Importance sampling for Lambda-coalescents in the infinitely many sites model
2011
We present and discuss new importance sampling schemes for the approximate computation of the sample probability of observed genetic types in the infinitely many sites model from population genetics. More specifically, we extend the 'classical framework', where genealogies are assumed to be governed by Kingman's coalescent, to the more general class of Lambda-coalescents and develop further Hobolth et. al.'s (2008) idea of deriving importance sampling schemes based on 'compressed genetrees'. The resulting schemes extend earlier work by Griffiths and Tavar\'e (1994), Stephens and Donnelly (2000), Birkner and Blath (2008) and Hobolth et. al. (2008). We conclude with a performance comparison o…
Are locally finite MV-algebras a variety?
2021
We answer Mundici's problem number 3 (D. Mundici. Advanced {\L}ukasiewicz calculus. Trends in Logic Vol. 35. Springer 2011, p. 235): Is the category of locally finite MV-algebras equivalent to an equational class? We prove: (i) The category of locally finite MV-algebras is not equivalent to any finitary variety. (ii) More is true: the category of locally finite MV-algebras is not equivalent to any finitely-sorted finitary quasi-variety. (iii) The category of locally finite MV-algebras is equivalent to an infinitary variety; with operations of at most countable arity. (iv) The category of locally finite MV-algebras is equivalent to a countably-sorted finitary variety. Our proofs rest upon th…
La formación tecnológica del profesorado de música en educación secundaria; un estudio de intervención basado en la integración de contenidos musical…
2021
El presente trabajo de carácter descriptivo-exploratorio forma parte de un trabajo de mayor alcance realizado en Chile y España. Su objetivo ha sido fortalecer la formación tecnológica de los futuros profesores de música en Ed. Secundaria mediante el diseño, la implementación y la evaluación de una materia en dos cohortes consecutivas (cohortes 2017 y 2018, n= 81). En el diseño de intervención se tuvo en cuenta en su diseño componentes de alfabetización tecnológica, y dos estrategias de aprendizaje: proyectos (ABP) y trabajo cooperativo. La novedad del diseño consiste en la adaptación de un marco teórico de integración de contenidos disciplinares-tecnológicos-pedagógicos denominado TPACK q…
Cambiamenti climatici e insegnamento/apprendimento della Fisica: Una proposta didattica
2013
From more than 10 years, the European Union recommends significant reforms for science teaching at school in order to include environmental issues in the scientific curricula. As Osborne and Dillon argue in an important European Report (Science Education in Europe: Critical Reflections. A Report to the Nuffield Foundation, 2008), although climate change is one of the five major problems facing humanity in the coming century, there is still little emphasis within the science curriculum on discussion or analysis of environmental issues. In this paper a pilot study is presented and discussed. It focuses on the issue of climate change (global warming and the greenhouse effect) carried out with …
Semmes surfaces and intrinsic Lipschitz graphs in the Heisenberg group
2018
A Semmes surface in the Heisenberg group is a closed set $S$ that is upper Ahlfors-regular with codimension one and satisfies the following condition, referred to as Condition B. Every ball $B(x,r)$ with $x \in S$ and $0 < r < \operatorname{diam} S$ contains two balls with radii comparable to $r$ which are contained in different connected components of the complement of $S$. Analogous sets in Euclidean spaces were introduced by Semmes in the late $80$'s. We prove that Semmes surfaces in the Heisenberg group are lower Ahlfors-regular with codimension one and have big pieces of intrinsic Lipschitz graphs. In particular, our result applies to the boundary of chord-arc domains and of redu…
Prevalence and determinants of secondary posttraumatic growth following trauma work among medical personnel: a cross sectional study
2021
Background: People helping trauma victims as a part of their work may experience positive results, known as Secondary Posttraumatic Growth (SPTG). Aim: The present study aimed to determine the prevalence and determinants of SPTG among medical personnel, considering occupational load, job satisfaction, social support, and cognitive processing of trauma, understood as cognitive coping strategies. Methods: Subjects comprised 419 representatives of the medical profession, including paramedics and nurses. The age of the subjects varied from 19 to 65 (M = 39.60; SD = 11.03). Four standard measurement tools were utilized: the Secondary Posttraumatic Growth Inventory, the Job Satisfaction Scale, th…
Le collège au coeur des inégalités
2006
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Correlation study of GAPDH, Bcl-2, and Bax protein immunoexpression in patients with colorectal adenocarcinoma.
2018
Introduction Colorectal cancer (CRC) is the third and second most commonly diagnosed cancer worldwide in males and females, respectively. Despite prominent progress in diagnosis and treatment, the recurrence rates are still high. A tumour hypoxic environment leads to an increase in glycolytic metabolism. The crucial intermediate component of glycolysis, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), could play a significant role in cancer progression. An increased level of GAPDH has been described in oncogene-induced transformation and anti-apoptotic function. In other studies, GAPDH has been involved in apoptosis induction. Aim We examined colorectal adenocarcinoma samples to assess the…