Search results for "Secret"

showing 10 items of 1132 documents

Trichuris trichiura egg extract proteome reveals potential diagnostic targets and immunomodulators.

2021

The proteomic analysis was performed at the proteomics facility of SCSIE, University of Valencia (Burjassot, Spain) that belongs to ProteoRed, PRB2-ISCIII, Madrid, Spain. We also thank Dr. Tatiana Corey, Dr. Amy Beierschmitt and Dr. Pompei Bolfa for their support during sample collection.

ADULT WORMSSerum ProteinsProteomePhysiologyProteomesEggsRC955-962Egg proteinBiochemistryHeat Shock ResponseMedical ConditionsReproductive PhysiologyArctic medicine. Tropical medicineINFECTIONChlorocebus aethiopsMedicine and Health SciencesSUPEROXIDE-DISMUTASECellular Stress ResponsesImmune System ProteinsbiologySoil-transmitted helminthiasisHelminth ProteinsNEMATODEBird EggsInfectious DiseasesTrichurisCell ProcessesHelminth InfectionsProteomeFemaleAntibodyPublic aspects of medicineRA1-1270EXCRETORY-SECRETORY PRODUCTSResearch ArticleNeglected Tropical DiseasesTrichuriasisImmunologyMicrobiologyVitellogeninProtein Domainsparasitic diseasesmedicineParasitic DiseasesHEAT-SHOCK PROTEINSAnimalsHumansTrichuriasisPARASITEOvumImmunodiagnosticsMOLECULAR-CLONINGIDENTIFICATIONPublic Health Environmental and Occupational HealthBiology and Life SciencesProteinsMASS-SPECTROMETRYCell Biologymedicine.diseasebiology.organism_classificationTropical DiseasesSoil-Transmitted HelminthiasesAntigens Helminthbiology.proteinTrichuris trichiuraPLoS Neglected Tropical Diseases
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P3–244: The impact of LRP on APP metabolism along the secretory pathway

2006

APP metabolismPsychiatry and Mental healthCellular and Molecular NeuroscienceDevelopmental NeuroscienceEpidemiologyChemistryHealth PolicyNeurology (clinical)Geriatrics and GerontologySecretory pathwayCell biologyAlzheimer's & Dementia
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Safety and immunomodulatory effects of three probiotic strains isolated from the feces of breast-fed infants in healthy adults: SETOPROB study.

2013

We previously described the isolation and characterization of three probiotic strains from the feces of exclusively breast-fed newborn infants: Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036. These strains were shown to adhere to intestinal mucus in vitro, to be sensitive to antibiotics and to resist biliary salts and low pH. In the present study, a multicenter, randomized, double-blind, placebo-controlled trial with 100 healthy volunteers in three Spanish cities was carried out to evaluate the tolerance, safety, gut colonization and immunomodulatory effects of these three probiotics. Volunteers underwent a 15-day washout perio…

ARN Bacterianoved/biology.organism_classification_rank.speciesPhysiologylcsh:Medicine:Phenomena and Processes::Biological Phenomena::Ecological and Environmental Phenomena::Environment::Ecosystem::Biodiversity::Biota::Microbiota [Medical Subject Headings]law.inventionFecesProbioticAntibioticslawLactobacillus:Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Child Nutritional Physiological Phenomena::Infant Nutritional Physiological Phenomena::Breast Feeding [Medical Subject Headings]lcsh:Science:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::RNA::RNA Bacterial [Medical Subject Headings]BifidobacteriumMultidisciplinaryBifidobacterium brevebiologyLacticaseibacillus rhamnosusMicrobiotaHibridación in SituInterleukin-10:Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Lactobacillaceae::Lactobacillus [Medical Subject Headings]Breast FeedingBloodCytokinesFemaleResearch ArticleAdult:Anatomy::Fluids and Secretions::Feces [Medical Subject Headings]Lactobacillus paracasei:Organisms::Bacteria::Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Bacteria::Gram-Positive Endospore-Forming Rods::Clostridium::Clostridium difficile [Medical Subject Headings]Microbiology:Chemicals and Drugs::Nucleic Acids Nucleotides and Nucleosides::Nucleic Acids::Nucleic Acid Probes::Oligonucleotide Probes [Medical Subject Headings]Double-Blind MethodLactobacillus rhamnosusHumansImmunologic Factors:Analytical Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Histocytological Preparation Techniques::Staining and Labeling::In Situ Hybridization [Medical Subject Headings]FecesSafety studiesved/biologyProbioticslcsh:RClostridium difficile:Organisms::Bacteria::Gram-Positive Bacteria::Actinobacteria::Bifidobacterium [Medical Subject Headings]biology.organism_classificationImmunoglobulin ALactobacilluslcsh:QInterleukin-4BifidobacteriumBreast feedingSondas de OligonucleótidosPLoS ONE
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NEW THERAPEUTIC PERSPECTIVES IN IRRITABLE BOWEL SYNDROME: TARGETING LOW-GRADE INFLAMMATION, IMMUNO-NEUROENDOCRINE AXIS, MOTILITY, SDECRETION AND BEYO…

2017

Irritable bowel syndrome (IBS) is a chronic, recurring, and remitting functional disorder of the gastrointestinal tract characterized by abdominal pain, distention, and changes in bowel habits. Although there are several drugs for IBS, effective and approved treatments for one or more of the symptoms for various IBS subtypes are needed. Improved understanding of pathophysiological mechanisms such as the role of impaired bile acid metabolism, neurohormonal regulation, immune, dysfunction, the epithelial barrier and the secretory properties of the gut has led to advancements in the treatment of IBS. With regards to therapies for restoring intestinal permeability, multiple studies with prebiot…

Abdominal painmedicine.medical_specialtyReviewFunctional disorderGastroenterologyPermeabilityBile Acids and Salts03 medical and health scienceschemistry.chemical_compound0302 clinical medicineGastrointestinal AgentsMesalazineInternal medicineImmunoendocrine axisTherapy; Low grade inflammation; Motility; Secretion; Irritable bowel syndrome; Immunoendocrine axismedicineHumansSecretionIrritable bowel syndromeInflammationClinical Trials as TopicGastrointestinal agentSettore MED/12 - GastroenterologiaLow grade inflammationIntestinal permeabilitybusiness.industryGastroenterologyMotilityDrugs InvestigationalGeneral Medicinemedicine.diseaseAbdominal PainRifaximinIntestinesClinical trialIrritable bowel syndromeSettore MED/18 - Chirurgia GeneraleTreatment Outcomechemistry030220 oncology & carcinogenesis030211 gastroenterology & hepatologyTherapymedicine.symptomGastrointestinal Motilitybusiness
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Modulation by Scopolamine, Acetylcholine and Choline of the Evoked Release of Acetylcholine from the Guinea Pig Myenteric Plexus: Evidence for a Musc…

1981

There is evidence that the release of acetylcholine (ACh) from the guinea pig myenteric plexus is controlled via presynaptic muscarine receptors. Muscarinic antagonists such as atropine enhance the release evoked by either electrical field stimulation, by nicotinic drugs or by high K+ concentrations (4,7,10). On the other hand, the muscarinic agonist oxotremorine inhibits the evoked release of ACh (7). A comparable feedback inhibition has been described for the release of ACh from central cholinergic nerves (for review, see Ref. 12). However, it has so far not been shown whether the physiological transmitter itself is able to depress the release of neuronal ACh. We have, therefore, studied …

Acetylcholine secretionChemistryAnesthesiaMuscarinic acetylcholine receptormedicineMuscarinic acetylcholine receptor M3Muscarinic acetylcholine receptor M2Muscarinic acetylcholine receptor M1PharmacologyMuscarinic agonistMyenteric plexusAcetylcholinemedicine.drug
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An in vitro model for the study of human parathyroid gland tissue: Single cell suspensions and monolayer cultures

1982

An in vitro model for studies of parathyroid physiology is described using single cell suspensions and adherent monolayer cultures of human parathyroid tissue. The isolated cells were viable and maintained functional properties tested by calcium and magnesium sensitivity. Parathyroid hormone (PTH) secretion could be suppressed by rising calcium and magnesium concentrations. The secretory behaviour of the cells was not altered by cultivation or cryopreservation. The morphological integrity of the individual cells after mechanical and enzymatic preparation was confirmed by light and electron microscopy.

AdenomaCellchemistry.chemical_elementParathyroid hormoneCalciumModels BiologicalCryopreservationlaw.inventionParathyroid GlandslawmedicineHumansMagnesiumSecretionCells Culturedchemistry.chemical_classificationMagnesiumGeneral MedicineParathyroid Neoplasmsmedicine.anatomical_structureEnzymechemistryBiochemistryParathyroid HormoneCalciumFemaleElectron microscopehormones hormone substitutes and hormone antagonistsResearch in Experimental Medicine
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A Good Breath of Oxygen for Beta-Like Cells Obtained From Porcine Exocrine Pancreatic Tissue

2011

Ischemia is the most important factor that affects organ survival during harvesting. The two-layer method (TLM) is one of several cold storage solutions that seeks to preserve organs and cells avoiding in vivo and in vitro ischemia. We compared the retrieval of beta-like elements from exocrine pancreatic cells using TLM versus University of Wisconsin (UW) solutions. For this purpose pancreata laparoscopically harvested from 20 female pigs were preserved in UW solution or TLM before digestion. The resulting exocrine cells were divided into 2 groups: the first was cultured in a designed medium to allow differentiation into beta-like cells and the second was cryopreserved before the differenti…

AdenosineTime FactorsCell SurvivalSwineAllopurinolCellular differentiationOrgan Preservation Solutionsbeta-like-cells porcine esocrine pancreatic tisuueCold storageCell SeparationCryopreservationAndrologyPancreatectomyRaffinoseIn vivoSettore BIO/13 - Biologia ApplicataInsulin-Secreting CellsmedicineAnimalsInsulinViaspanCells CulturedCryopreservationFluorocarbonsTransplantationbusiness.industryCell DifferentiationAnatomyGlutathionePancreas ExocrineIn vitroCulture MediaOxygenTransplantationSettore MED/18 - Chirurgia GeneraleGlucosemedicine.anatomical_structureTissue and Organ HarvestingFemaleLaparoscopySurgeryPancreasbusiness
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Analysis of tear proteins by one- and two-dimensional thin-layer iosoelectric focusing, sodium dodecyl sulfate electrophoresis and lectin blotting. D…

1998

· Background: Isoelectric focusing (IEF) of tear proteins has not yet been carried out in a satisfactory way. Two-dimensional (2D) electrophoresis, especially in the combination of IEF with SDS, is able to differentiate between proteins in detail. The purpose of this study was therefore to analyze tear proteins by 1D IEF alone and in combination with a 2D pattern, and by IEF followed by lectin staining. · Methods: Ampholines, covering a broad range from pH 3 to pH 10, were applied. After IEF, semi-dry blotting and incubation with a group II lectin and two group V lectins was performed. · Results: Tear proteins could be separated into 31 single bands. Tear-specific pre-albumin (TSPA), lactof…

AdolescentImmunoblottingCellular and Molecular Neurosciencechemistry.chemical_compoundSurface-Active AgentsLectinsHumansElectrophoresis Gel Two-DimensionalSodium dodecyl sulfateCystatin CEye Proteinschemistry.chemical_classificationbiologyLactoferrinIsoelectric focusingTransferrinLectinSodium Dodecyl SulfateCerebrospinal Fluid ProteinsCystatinsSensory SystemsOphthalmologyLactoferrinIsoelectric pointchemistryBiochemistryTransferrinImmunoglobulin GTearsImmunoglobulin A Secretorybiology.proteinFemaleMuramidaseCystatinLysozymeIsoelectric FocusingGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie
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Maternal Microbiota, Cortisol Concentration, and Post-Partum Weight Recovery Are Dependent on Mode of Delivery

2020

© 2020 by the authors.

Adult0301 basic medicineHydrocortisonemicrobiomePhysiologylcsh:TX341-641cortisolBiologydigestive systemArticlecortisol delivery mode microbiome post-partum weight retentionBody Mass Indexdelivery modeFeces03 medical and health sciencesfluids and secretions0302 clinical medicinePregnancyHumansMicrobiomeSalivaSalivary cortisolPost partum2. Zero hunger030219 obstetrics & reproductive medicineNutrition and DieteticsBacteriaCesarean Sectionpost-partum weight retentionVaginal deliveryBody WeightPostpartum Periodfood and beveragesDelivery ObstetricDelivery modeGastrointestinal Microbiome3. Good healthstomatognathic diseases030104 developmental biologyMode of delivery16s rrna gene sequencingFemalelcsh:Nutrition. Foods and food supplyFood ScienceHormoneNutrients
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Long-term graft function of adult rat and human islets encapsulated in novel alginate-based microcapsules after transplantation in immunocompetent di…

2005

We describe the results of the first study to show that adult rat and human islets can be protected against xenogenic rejection in immunocompetent diabetic mice by encapsulating them in a novel alginate-based microcapsule system with no additional permselective membrane. Nonencapsulated islets lost function within 4–8 days after being transplanted into diabetic Balb/c mice, whereas transplanted encapsulated adult rat or human islets resulted in normoglycemia for >7 months. When rat islet grafts were removed 10 and 36 weeks after transplantation, the mice became immediately hyperglycemic, thus demonstrating the efficacy of the encapsulated islets. The explanted capsules showed only a …

AdultBlood GlucoseMaleendocrine systemmedicine.medical_specialtyTime FactorsRatónAlginatesEndocrinology Diabetes and Metabolismmedicine.medical_treatmentIslets of Langerhans TransplantationCapsulesGraft functionIslets of LangerhansMiceGlucuronic AcidDiabetes mellitusInternal medicineInsulin SecretionInternal MedicineDiabetes MellitusMedicineAnimalsHumansInsulinInsulin secretiongeographyMice Inbred BALB Cgeography.geographical_feature_categorybusiness.industryHexuronic AcidsGraft SurvivalImmunosuppressionDiabetic mousemedicine.diseaseIsletRatsTransplantationEndocrinologybusinessDiabetes
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