Search results for "Sense organ"

Changes in the Tear Protein Patterns of Diabetic Patients Using Two-Dimensional Electrophoresis

2002

Four to five million Germans suffer from diabetes mellitus, and worldwide there are about 100 million people that suffer with the disease. In diabetic patients, dry eye and other ocular surface diseases occur more often than in healthy subjects. Very little is known about the alterations in tears caused by diabetes mellitus, or its influence on the pathogenesis of e.g., the dry eye disease. Recent studies from our group showed that there are differences in the one-dimensional electrophoretic tear protein separations between diabetic patients and healthy volunteers.1,2 The aim of this study is to analyze the tear protein patterns of patients suffering from diabetes (DIA) (Fig.l), and to comp…

Usability of photoplethysmography method in estimation of conduit artery stiffness

2011

Three channel photoplethysmography (PPG) signal waveform studies of leg conduit arteries during a provocative occlusion test were performed. PPG waveform second derivative amplitude ratio and arterial pulse wave velocity values showed significant correlations with ultrasound (US) reference method of local and regional arterial stiffness (AS), showing the ability to use PPG for AS change quantitative assessment.

A time-geographic approach for visualizing the paths of intervention for persons with severe mental illness

2017

Living conditions for persons with severe mental illness (SMI) in Sweden have changed dramatically in recent decades, mainly due to the closure of mental hospitals in the 1990s and the subsequent d ...

Möglichkeiten und Grenzen der Spiral-CT bei der Untersuchung von Nierenbeckenkarzinomen

1994

PURPOSE To assess the value of spiral CT in comparison to conventional CT in the staging of renal pelvic carcinoma. PATIENTS AND METHODS 35 patients with renal pelvic carcinoma underwent preoperative CT; conventional technique (n = 21) and spiral CT (n = 14) with the reconstruction of thin sections were compared. RESULTS Non-invasive or minimal invasive tumours (TA, T1, T2) could not be differentiated with either technique. Small, flat tumours (TA) or multicentric tumours may be missed, even if spiral scanning is applied. The separation of local tumour growth from infiltration is significantly improved by spiral CT (12 of 12 patients instead of 18 out of 21 patients with the conventional te…

Clinical Implications in Perimetry After Photorefractive Keratectomy

2003

Through refractive surgery, it is now possible to correct various ametropias using new techniques such as photorefractive keratectomy (PRK). We hypothesized that patients submitting to PRK show higher peripheral thresholds attributable to poorer retinal quality than normal patients. However, no difference were found when comparing glaucoma with PRK patients. Thus, early glaucoma following PRK may be masked by the previous surgery.

Expanded forehead (Fricke) flap for large defect of lateral canthal area

1993

The use of an expanded forehead (Fricke) flap to repair large full thickness defects of the lateral canthus and/or of the upper eyelid is presented. The reconstruction is performed in two stages. In the first stage, a rectangular, 25 ml tissue expander (6 cm in width and 2 cm in length) is inserted under the skin lateral to and above the eyebrow; expansion is completed in about three weeks. At the second stage, the lesion is excised, and the laterally based expanded flap is elevated. Using the expanded Fricke flap, thinner, abundant skin is obtained, and the donor site is directly closed, without grafting and without distorting the eyebrow. If there is a shortage of conjunctiva, this can be…

2018

Background: Change in the prevalence of raised blood pressure could be due to both shifts in the entire distribution of blood pressure (representing the combined effects of public health interventions and secular trends) and changes in its high-blood-pressure tail (representing successful clinical interventions to control blood pressure in the hypertensive population). Our aim was to quantify the contributions of these two phenomena to the worldwide trends in the prevalence of raised blood pressure. Methods: We pooled 1018 population-based studies with blood pressure measurements on 88.6 million participants from 1985 to 2016. We first calculated mean systolic blood pressure (SBP), mean dia…

A case-control study on risk factors for nuclear, cortical and posterior subcapsular cataract: The Casteldaccia Eye Study

2005

. Purpose: To investigate risk factors for nuclear, cortical and posterior subcapsular age-related cataract. Methods: A case-control study was carried out on subjects aged 40 years and older, living in Casteldaccia, Sicily. Twenty-seven potential risk factors were investigated. Nuclear, cortical and posterior subcapsular opacities of the lens were classified according to the Lens Opacities Classification System II. Subjects with advanced lens opacities represented the cases, while an identical number of subjects without or with early cataract, matched for sex and age, were recruited as controls from within the same population. Results: Univariate analysis showed that myopia and iris atrophy…

Elevated intraocular pressure induces neuron-specific β-III-tubulin expression in non-neuronal vascular cells.

2019

Purpose Pathological alterations within optic nerve axons and progressive loss of the parental retinal ganglion cell (RGC) bodies are characteristics of glaucomatous neuropathy. Abnormally elevated intraocular pressure (IOP) is thought to be the major risk factor for most forms of glaucomatous changes, while lowering of the IOP is the mainstream of treatment. However, the pathophysiological mechanisms involved in neurodegenerative changes are poorly understood. It remains still a matter of debate whether elevated IOP harms the neurons directly or indirectly through alterations in the retinal vascularization. Methods We analysed morphological and molecular changes within the retina exposed t…

The LDL receptor in the retina: the missing link in aging, the new target in dietary prevention

2012

National audience; Purpose: The discovery of the LDL receptor (LDLR) in 1985 by Brown and Goldstein was awarded by a Nobel Prize. The LDLR has initially been identified for its role in mediating the endocytosis of LDL particles in the vascular endothelium. The deposition of lipids, including cholesterol and cholesteryl esters in Bruch’s Membrane in the one hand, and in the vessel intima in the other hand, is one of the common features of age related macular degeneration (AMD) and cardiovascular disease (CVD). Dietary habits with high intakes of omega 3 long chain fatty acids (LCFA) have been associated with AMD prevention. Similar effects have been demonstrated in CVD prevention. The mechan…